Risk stratified usage of antibiotic-loaded bone cement for primary total knee arthroplasty: Short term infection outcomes with a standardized cement protocol

Journal of Arthroplasty

Volumn 29, Issue 8, 2014, Pages 1622-1624

  Qadir, Rabah ^a   Sidhu, Sanbir ^b   Ochsner, J Lockwood ^a,b   Meyer, Mark S ^a,b   Chimento, George F ^a,b  

^a OCHSNER CLINIC FOUNDATION   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Antibiotic cement; High risk; Primary knee arthroplasty

Indexed keywords

ANTIBIOTIC BONE CEMENT; BONE CEMENT;

AGED; ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HUMAN; INFECTION RATE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIMARY TOTAL KNEE ARTHROPLASTY; SHORT COURSE THERAPY; SURGICAL INFECTION; TOTAL KNEE REPLACEMENT;

ANTIBIOTIC CEMENT; HIGH-RISK; PRIMARY KNEE ARTHROPLASTY;

AGED; ANTI-BACTERIAL AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BONE CEMENTS; COMORBIDITY; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PROSTHESIS-RELATED INFECTIONS; RETROSPECTIVE STUDIES; RISK FACTORS; TREATMENT OUTCOME;

EID: 84905096518     PISSN: 08835403     EISSN: 15328406     Source Type: Journal    
DOI: 10.1016/j.arth.2014.02.032     Document Type: Article

References (21)

1. Maathuis P.G., Neut D., Busscher H.J., et al. Perioperative contamination in primary total hip arthroplasty. Clin Orthop Relat Res 2005, 433:136.
2. Chiu F.Y., Chen M.C., Lin C.F., et al. Cefuroxime-impregnated cement in primary total knee arthroplasty: a prospective; randomized study of three hundred and forty knees. J Bone Joint Surg Am 2002, 84-A(5):759.
3. Gandhi R., Razak F., Pathy R., et al. Antibiotic bone cement and the incidence of deep infection after total knee arthroplasty. J Arthroplasty 2009, 24(7):1015.
4. Darouiche R.O. Treatment of infections associated with surgical implants. N Engl J Med 2004, 350(14):1422.
5. Sculco T.P. The economic impact of infected total joint arthroplasty. Instr Course Lect 1993, 42:349.
6. Baker A.S., Greenham L.W. Release of gentamicin from acrylic bone cement. Elution and diffusion studies. J Bone Join Surg Am 1988, 70(10):1551.
7. Penner M.J., Duncan C.P., Masri B.A. The in vitro elution characteristics of antibiotic-loaded CMW and Palacos-R bone cements. J Arthroplasty 1999, 14:209.
8. Fletcher M.D., Spencer R.F., Langkamer V.G., et al. Gentamicin concentrations in diagnostic aspirates from 25 patients with hip and knee arthroplasties. Acta Orthop Scand 2004, 75:173.
9. Powles J.W., Spence R.F., Lovering A.M. Gentamicin release from old cement during revision hip arthroplasty. J Bone Joint Surg Br 1998, 80:607.
10. Engesaeter L.B., Lie S.A., Espehaug B., et al. Antibiotic prophylaxis in total hip arthroplasty: effects of antibiotic proplylaxis systemically and in bone cement on the revision rate of 22,170 primary hip replacements followed 0-14 years in the Norwegian Arthroplasty Register. Acta Orthop Scand 2003, 74:644.
11. Josefsson G., Kolmert L. Prophylaxis with systematic antibiotics versus gentamicin bone cement in total hip arthroplasty. A ten-year survey of 1,688 hips. Clin Orthop Relat Res 1993, 292:210.
12. Lynch M., Esser M.P., Shelley P., et al. Deep infection in Charnley low-friction arthroplasty. Comparison of plain and gentamicin-loaded cement. J Bone Joint Surg Br 1987, 69:355.
13. Parvizi J., Saleh K.J., Ragland P.S., et al. Efficacy of antibiotic-impregnated cement in total hip replacement. Acta Orthop 2008, 79(3):335.
14. Namba R.S., Chen Y., Paxton E.W., et al. Outcomes of routine use of antibiotic-loaded cement in primary total knee arthroplasty. J Arthroplasty 2009, 24(6):44.
15. Jiranek W.A., Hanssen A.D., Greenwald S. Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement. J Bone Joint Surg Am 2006, 88A(11):2487.
16. Malchau H., Herberts P., Ahnfelt L. Prognosis of total hip replacement in Sweden. Follow-up of 92,675 operations performed 1978-1990. Acta Orthop Scand 1993, 64:497.
17. Jämsen E., Huhtala H., Puolakka T., et al. Risk factors for infection after knee arthroplasty. A register-based analysis of 43,149 cases. J Bone Joint Surg Am 2009, 91(1):38.
18. Lidgren L. Joint prosthetic infections: a success story. Acta Orthop Scand 2001, 72:553.
19. Espehaug B., Engesaeter L.B., Vollset S.E., et al. Antibiotic prophylaxis in total hip arthroplasty. Review of 10,905 primary cemented total hip replacements reported to the Norwegian arthroplasty register, 1987 to 1995. J Bone Joint Surg Br 1997, 79:590.
20. McQueen M., Littlejohn A., Hughes S.P. A comparison of systemic cefuroxime and cefuroxime loaded bone cement in the prevention of early infection after total joint replacement. Int Orthop 1987, 11:241.
21. Cummins J.S., Tomek I.M., Kantor S.R., et al. Cost-effectiveness of antibiotic-impregnated bone cement in primary total hip arthroplasty. J Bone Joint Surg Am 2009, 91(3):634.