Cytosine arabinoside and mitoxantrone followed by second allogeneic transplant for the treatment of children with refractory juvenile myelomonocytic leukemia

Journal of Pediatric Hematology/Oncology

Volumn 36, Issue 6, 2014, Pages 491-494

  Patel, Sachit A ^a   Coulter, Don W ^a   Grovas, Alfred C ^a   Gordon, Bruce G ^a   Harper, James L ^a   Warkentin, Phyllis I ^a,b   Wisecarver, James L ^b   Sanger, Warren G ^b   Coccia, Peter F ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

allogeneic transplant; chimerism; JMML

Indexed keywords

CYTARABINE; MITOXANTRONE;

ACUTE GRAFT VERSUS HOST DISEASE; ADOLESCENT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CHILD; CHILD HEALTH CARE; CHRONIC GRAFT VERSUS HOST DISEASE; CLINICAL ARTICLE; DOSE RESPONSE; DRUG MEGADOSE; GRAFT VERSUS LEUKEMIA EFFECT; HLA MATCHING; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFANT; JUVENILE MYELOMONOCYTIC LEUKEMIA; LEUKEMIA RELAPSE; MALE; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SHORT TANDEM REPEAT; TREATMENT INDICATION; TREATMENT OUTCOME; TREATMENT PLANNING;

ANTIMETABOLITES, ANTINEOPLASTIC; CHILD; CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; CYTARABINE; DISEASE-FREE SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INFANT; LEUKEMIA, MYELOMONOCYTIC, JUVENILE; MALE; MITOXANTRONE; RECURRENCE; RETREATMENT; TISSUE DONORS; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS;

EID: 84905090448     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0000000000000077     Document Type: Article

References (27)

1. Gassas A, Doyle J, Dror Y, et al. Basic classification and a comprehensive examination of pediatric myeloproliferative syndromes. J Pediatr Hematol Oncol. 2005;27:192-196.
2. Emanuel PD. Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. Leukemia. 2008;22:1335-1342.
3. Niemeyer CM, Kratz CP. Paediatric myelodysplastic syndromes and juvenile myelomonocytic leukaemia: Molecular classification and treatment options. Br J Haematol. 2008;140: 610-624.
4. Niemeyer CM, Locatelli F. Chronic Myeloproliferative Disorders. Childhood Luekemias. 2nd ed. New York: Cambridge University Press; 2006:571-598.
5. Arico M, Biondi A, Pui CH. Juvenile myelomonocytic leukemia. Blood. 1997;90:479-488.
6. Side LE, Emanuel PD, Taylor B, et al. Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1. Blood. 1998;92:267-272.
7. Bentires-Alj M, Paez JG, David FS, et al. Activating mutations of the Noonan syndrome-Associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res. 2004;64:8816-8820.
8. Sheng XM, Kawamura M, Ohnishi H, et al. Mutations of the RAS genes in childhood acute myeloid leukemia, myelodysplastic syndrome and juvenile chronic myelocytic leukemia. Leuk Res. 1997;21:697-701.
9. Schubbert S, Zenker M, Rowe SL, et al. Germline KRAS mutations cause Noonan syndrome. Nat Genet. 2006;38: 331-336.
10. Loh ML. Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukemia. Br J Haematol. 2011; 152:677-687.
11. Locatelli F, Nollke P, Zecca M, et al. HSCT in children with JMML: Results of EWOG-MDS/EBMT trial. Blood. 2005;105: 410-419.
12. Niemeyer C, Arico M, Basso G, et al. Chronic myelomonocytic leukemia in childhood: A retrospective analysis of 110 cases. Blood. 1997;89:3534-3534.
13. Chan RJ, Cooper T, Kratz CP, et al. Juvenile myelomonocytic leukemia: A report from the 2nd International JMML Symposium. Leuk Res. 2009;33:355-362.
14. Yusuf U, Frangoul HA, Gooley TA, et al. Allogeneic bone marrow transplantation in children with myelodysplastic syndrome or juvenile myelomonocytic leukemia: The Seattle experience. Bone Marrow Transplant. 2004;33:805-814.
15. Smith FO, King R, Nelson G, et al. Unrelated donor bone marrow transplantation for children with juvenile myelomonocytic leukaemia. Br J Haematol. 2002;116: 716-724.
16. Yoshimi A, Mohamed M, Beirings M, et al. Second allogeneic hematopoietic stem cell transplantation (HSCT) results in outcome similar to that of first HSCT for patients with juvenile myelomonocytic leukemia. Leukemia. 2007;21:556-560.
17. Locatelli F, Lucarelli B. Treatment of disease recurrence after allogeneic hematopoietic stem cell transplantation in children with juvenile myelomonocytic leukemia: A great challenge still to be won. Pediatr Blood Cancer. 2013;60:1-2.
18. Dave BJ, Nelson M, Sanger WG. Lymphoma Cytogenetics. Clin Lab Med. 2011;31:725-761.
19. Horsman DE, Conners JM, Pantzar T, et al. Analysis of secondary chromosomal alterations in 165 cases of follicular lymphoma with t(14:18). Genes Chromosomes Cancer. 2001;30:375-382.
20. Rubocki RJ, Parsa JR, Hershfield MS, et al. Full hematopoietic engraftment after allogeneic bone marrow transplantation without cytoreduction in a child with severe combined immunodeficiency. Blood. 2001;97:809-811.
21. Manabe A, Okamura J, Yumera-Yagi K, et al. Allogeneic hematopoietic stem cell transplantation for 27 children with juvenile myelomonocytic leukemia diagnosed based on the criteria of the International JMML Working Group. Leukemia. 2002;16:645-649.
22. Bergstraesser E, Hasle H, Rogge T, et al. Non-hematopoietic stem cell transplantation treatment of juvenile myelomonocytic leukemia: A retrospective analysis and definition of response criteria. Pediatr Blood Cancer. 2007;49:629-633.
23. Korthof ET, Snijder PP, de Graaff AA, et al. Allogeneic bone marrow transplantation for juvenile myelomonocytic leukemia: A single center experience of 23 patients. Bone Marrow Transplant. 2005;35:455-461.
24. Yoshimi A, Bader P, Matthes-Martin S, et al. Donor leukocyte infusion after hematopoietic stem cell transplantation in patients with juvenile myelomonocytic leukemia. Leukemia. 2005;19:971-977.
25. Inagaki J, Fukano R, Nishiwaka T, et al. Outcomes of Immunological Interventions for mixed chimerism following allogeneic stem cell transplantation in children with juvenile myelomonocytic leukemia. Pediatr Blood Cancer. 2013;60: 116-120.
26. Locatelli F, Niemeyer C, Angelucci E, et al. Allogeneic bone marrow transplantation for chronic myelomonocytic leukemia in childhood: A report from the European Working Group on Myelodysplastic Syndrome in Childhood. J Clin Oncol. 1997;15:566-573.
27. Locatelli F, Crotta A, Ruggeri A, et al. Analysis of risk factors influencing outcomes after cord-blood-Transplantation in children with juvenile myelomonocytic leukemia. Blood. 2001;97:809-811.