Effect of thyroxine on brain microstructure in extremely premature babies: Magnetic resonance imaging findings in the TIPIT study

Pediatric Radiology

Volumn 44, Issue 8, 2014, Pages 987-996

  Ng, Sze May ^a,f   Turner, Mark A ^a   Gamble, Carrol ^a   Didi, Mohammed ^b   Victor, Suresh ^c   Atkinson, Jessica ^a   Sluming, Vanessa ^a   Parkes, Laura M ^c   Tietze, Anna ^d   Abernethy, Laurence J ^e   Weindling, Alan Michael ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b Alder Hey Children's Foundation Trust   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

^e ALDER HEY CHILDREN'S NHS FOUNDATION TRUST   (United Kingdom)

^f SOUTHPORT AND ORMSKIRK HOSPITAL NHS TRUST   (United Kingdom)

Author keywords

Brain microstructure; Diffusion tensor imaging; Diffusion weighted imaging; Infant; Magnetic resonance imaging; Premature; Thyroxine

Indexed keywords

LEVOTHYROXINE; PLACEBO; THYROXINE;

ARTICLE; BABY; BIRTH WEIGHT; BRAIN DEVELOPMENT; BRAIN REGION; CAPSULA INTERNA; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS CALLOSUM; DIFFUSION COEFFICIENT; DIFFUSION TENSOR IMAGING; ECHO PLANAR IMAGING; FRACTIONAL ANISOTROPY; HORMONE SUBSTITUTION; HUMAN; IMMATURITY; INFANT; MULTICENTER STUDY (TOPIC); NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OCCIPITAL LOBE; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); THYROXINE BLOOD LEVEL; WHITE MATTER; HYPOTHYROIDISM; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; SUBCLINICAL HYPOTHYROIDISM; TRACTOGRAPHY; ANISOTROPY; BLOOD; BRAIN; BRAIN MAPPING; CLINICAL TRIAL; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; FEMALE; GROWTH, DEVELOPMENT AND AGING; MALE; NEWBORN; PROCEDURES;

ANISOTROPY; BRAIN; BRAIN MAPPING; DIETARY SUPPLEMENTS; DIFFUSION TENSOR IMAGING; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFANT, EXTREMELY PREMATURE; INFANT, NEWBORN; MAGNETIC RESONANCE IMAGING; MALE; THYROXINE;

EID: 84905016496     PISSN: 03010449     EISSN: 14321998     Source Type: Journal    
DOI: 10.1007/s00247-014-2911-6     Document Type: Article

References (21)

1. Wood NS, Costeloe K, Gibson AT et al (2005) The EPICure study: associations and antecedents of neurological and developmental disability at 30 months of age following extremely preterm birth. Arch Dis Child Fetal Neonatal Ed 90:F134-F140 (Pubitemid 40333082)
2. Den Ouden AL, Kok JH, Verkerk PH et al (1996) The relation between neonatal thyroxine levels and neurodevelopmental outcome at age 5 and 9 years in a national cohort of very preterm and/or very low birth weight infants. Pediatr Res 39:142-145 (Pubitemid 26003534)
3. Leviton A, Paneth N, Reuss ML et al (1999) Hypothyroxinemia of prematurity and the risk of cerebral white matter damage. J Pediatr 134:706-711 (Pubitemid 30186813)
4. Ng SM, Turner MA, Gamble C et al (2013) An explanatory randomised placebo controlled trial of levothyroxine supplementation for babies born <28 weeks' gestation: results of the TIPIT trial. Trials 14:211
5. Schoonover CM, Seibel MM, Jolson DM et al (2004) Thyroid hormone regulates oligodendrocyte accumulation in developing rat brain white matter tracts. Endocrinology 145:5013-5020 (Pubitemid 39551120)
6. Gupta RK, Bhatia V, Poptani H et al (1995) Brain metabolite changes on in vivo proton magnetic resonance spectroscopy in children with congenital hypothyroidism. J Pediatr 126:389-392
7. Jagannathan NR, Tandon N, Raghunathan P et al (1998) Reversal of abnormalities of myelination by thyroxine therapy in congenital hypothyroidism: localized in vivo proton magnetic resonance spectroscopy (MRS) study. Brain Res Dev Brain Res 109:179-186 (Pubitemid 28383933)
8. Berman JI, Mukherjee P, Partridge SC et al (2005) Quantitative diffusion tensor MRI fiber tractography of sensorimotor white matter development in premature infants. Neuroimage 27:862-871 (Pubitemid 41317255)
9. Nair G, Tanahashi Y, Low HP et al (2005) Myelination and long diffusion times alter diffusion-tensor-imaging contrast in myelindeficient shiverer mice. Neuroimage 28:165-174 (Pubitemid 41393897)
10. Van Wassenaer AG, Briet JM, van Baar A et al (2002) Free thyroxine levels during the first weeks of life and neurodevelopmental outcome until the age of 5 years in very preterm infants. Pediatrics 110:534-539 (Pubitemid 34976682)
11. Oouchi H, Yamada K, Sakai K et al (2007) Diffusion anisotropy measurement of brain white matter is affected by voxel size: underestimation occurs in areas with crossing fibers. AJNR Am J Neuroradiol 28:1102-1106 (Pubitemid 46984552)
12. Jiang H, van Zijl PC, Kim J et al (2006) DtiStudio: resource program for diffusion tensor computation and fiber bundle tracking. Comput Methods Programs Biomed 81:106-116 (Pubitemid 43144442)
13. De Vries LS, Groenendaal F, van Haastert IC et al (1999) Asymmetrical myelination of the posterior limb of the internal capsule in infants with periventricular haemorrhagic infarction: an early predictor of hemiplegia. Neuropediatrics 30:314-319 (Pubitemid 30088323)
14. Rutherford MA, Pennock JM, Counsell SJ et al (1998) Abnormal magnetic resonance signal in the internal capsule predicts poor neurodevelopmental outcome in infants with hypoxic-ischemic encephalopathy. Pediatrics 102:323-328 (Pubitemid 28354996)
15. Jones DK (2010) Challenges and limitations of quantifying brain connectivity in vivo with diffusion MRI. Imaging Med 2:341-355
16. Correia S, Lee SY, Voorn T et al (2008) Quantitative tractography metrics of white matter integrity in diffusion-tensor MRI. Neuroimage 42:568-581
17. Partridge SC, Mukherjee P, Berman JI et al (2005) Tractography-based quantitation of diffusion tensor imaging parameters in white matter tracts of preterm newborns. J Magn Reson Imaging 22:467-474 (Pubitemid 41416405)
18. Dudink J, Lequin M, van Pul C et al (2007) Fractional anisotropy in white matter tracts of very-low-birth-weight infants. Pediatr Radiol 37:1216-1223 (Pubitemid 350160045)
19. Chau V, Brant R, Poskitt KJ et al (2012) Postnatal infection is associated with widespread abnormalities of brain development in premature newborns. Pediatr Res 71:274-279
20. Van Kooij BJ, de Vries LS, Ball G et al (2012) Neonatal tract-based spatial statistics findings and outcome in preterm infants. AJNR Am J Neuroradiol 33:188-194
21. Rose J, Butler EE, Lamont LE et al (2009) Neonatal brain structure on MRI and diffusion tensor imaging, sex, and neurodevelopment in very-low-birthweight preterm children. Dev Med Child Neurol 51: 526-535