Emodin opposes chronic unpredictable mild stress induced depressive-like behavior in mice by upregulating the levels of hippocampal glucocorticoid receptor and brain-derived neurotrophic factor

Fitoterapia

Volumn 98, Issue , 2014, Pages 1-10

  Li, Meng ^a   Fu, Qiang ^a   Li, Ying ^a   Li, Shanshan ^a   Xue, Jinsong ^a   Ma, Shiping ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antidepressant; Brain derived neurotrophic factor (BDNF); Chronic unpredictable mild stress (CUMS); Emodin; Glucocorticoid receptor (GR)

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; EMODIN; FLUOXETINE; GLUCOCORTICOID RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ARTICLE; CHRONIC STRESS; CHRONIC UNPREDICTABLE MILD STRESS; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DEPRESSION; FORCED SWIM TEST; HIPPOCAMPUS; LOCOMOTION; MALE; MOUSE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; SUCROSE PREFERENCE TEST; SUGAR INTAKE; TAIL SUSPENSION TEST; TREATMENT DURATION; ANIMAL; BLOOD; DISEASE MODEL; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; MENTAL STRESS; METABOLISM; UPREGULATION;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; DEPRESSION; DISEASE MODELS, ANIMAL; EMODIN; HIPPOCAMPUS; MALE; MICE, INBRED ICR; RECEPTORS, GLUCOCORTICOID; STRESS, PSYCHOLOGICAL; UP-REGULATION;

EID: 84905011465     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2014.06.007     Document Type: Article

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