Combination therapy of cilostazol and bepridil suppresses recurrent ventricular fibrillation related to J-wave syndromes

Heart Rhythm

Volumn 11, Issue 8, 2014, Pages 1441-1445

  Shinohara, Tetsuji ^a   Ebata, Yuki ^a   Ayabe, Reika ^a   Fukui, Akira ^a   Okada, Norihiro ^a   Yufu, Kunio ^a   Nakagawa, Mikiko ^a   Takahashi, Naohiko ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Bepridil; Cilostazol; J wave syndrome; Ventricular fibrillation

Indexed keywords

BEPRIDIL; CILOSTAZOL; ANTIARRHYTHMIC AGENT; PHOSPHODIESTERASE III INHIBITOR; TETRAZOLE DERIVATIVE;

ADULT; ARTICLE; BRUGADA SYNDROME; CLINICAL ARTICLE; DRUG DOSE INCREASE; DRUG EFFECT; DRUG WITHDRAWAL; ELECTROPHYSIOLOGY; FAINTNESS; FEMALE; FOLLOW UP; HEART MUSCLE CONDUCTION DISTURBANCE; HEART PALPITATION; HEART VENTRICLE FIBRILLATION; HUMAN; IMPLANTABLE CARDIOVERTER DEFIBRILLATOR; J WAVE SYNDROME; MALE; PRIORITY JOURNAL; RECURRENT DISEASE; SINUS TACHYCARDIA; ST SEGMENT ELEVATION; SUPRAVENTRICULAR TACHYCARDIA; SYMPTOM; DEATH, SUDDEN, CARDIAC; DOSE RESPONSE; DRUG COMBINATION; ELECTROCARDIOGRAPHY; PATHOPHYSIOLOGY; TREATMENT OUTCOME; VENTRICULAR FIBRILLATION; YOUNG ADULT;

ADULT; ANTI-ARRHYTHMIA AGENTS; BEPRIDIL; DEATH, SUDDEN, CARDIAC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; MALE; PHOSPHODIESTERASE 3 INHIBITORS; RECURRENCE; TETRAZOLES; TREATMENT OUTCOME; VENTRICULAR FIBRILLATION; YOUNG ADULT;

EID: 84904999756     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2014.05.001     Document Type: Article

References (16)

1. J. Shu, T. Zhu, L. Yang, C. Cui, and G.X. Yan ST-segment elevation in the early repolarization syndrome, idiopathic ventricular fibrillation, and the Brugada syndrome: cellular and clinical linkage J Electrocardiol 38 2005 26 32
2. C. Antzelevitch, and G.X. Yan J wave syndromes Heart Rhythm 7 2010 549 558
3. Survivors of out-of-hospital cardiac arrest with apparently normal heart Need for definition and standardized clinical evaluation. Consensus statement of the Joint Steering Committees of the Unexplained Cardiac Arrest Registry of Europe and of the Idiopathic Ventricular Fibrillation Registry of the United States Circulation 95 1997 265 272
4. M. Haissaguerre, F. Sacher, and A. Nogami et al. Characteristics of recurrent ventricular fibrillation associated with inferolateral early repolarization role of drug therapy J Am Coll Cardiol 53 2009 612 619
5. B. Belhassen, A. Glick, and S. Viskin Efficacy of quinidine in high-risk patients with Brugada syndrome Circulation 110 2004 1731 1737
6. 2+ current and developed tension in guinea-pig ventricular myocytes and papillary muscle: comparison with ibmx, milrinone, and cilostazol Cardiovasc Drugs Ther 13 1999 105 113
7. T. Tsuchiya, K. Ashikaga, T. Honda, and M. Arita Prevention of ventricular fibrillation by cilostazol, an oral phosphodiesterase inhibitor, in a patient with Brugada syndrome J Cardiovasc Electrophysiol 13 2002 698 701
8. T. Ohgo, H. Okamura, T. Noda, K. Satomi, K. Suyama, T. Kurita, N. Aihara, S. Kamakura, T. Ohe, and W. Shimizu Acute and chronic management in patients with brugada syndrome associated with electrical storm of ventricular fibrillation Heart Rhythm 4 2007 695 700
9. M. Sugao, A. Fujiki, K. Nishida, M. Sakabe, T. Tsuneda, J. Iwamoto, K. Mizumaki, and H. Inoue Repolarization dynamics in patients with idiopathic ventricular fibrillation: pharmacological therapy with bepridil and disopyramide J Cardiovasc Pharmacol 45 2005 545 549
10. T. Shinohara, N. Takahashi, T. Saikawa, and H. Yoshimatsu Characterization of j wave in a patient with idiopathic ventricular fibrillation Heart Rhythm 3 2006 1082 1084
11. M. Haissaguerre, N. Derval, and F. Sacher et al. Sudden cardiac arrest associated with early repolarization N Engl J Med 358 2008 2016 2023
12. S. Viskin, A.A. Wilde, and M.E. Guevara-Valdivia et al. Quinidine, a life-saving medication for Brugada syndrome, is inaccessible in many countries J Am Coll Cardiol 61 2013 2383 2387
13. T. Szél, I. Koncz, and C. Antzelevitch Cellular mechanisms underlying the effects of milrinone and cilostazol to suppress arrhythmogenesis associated with Brugada syndrome Heart Rhythm 10 2013 1720 1727
14. T. Anno, T. Furuta, M. Itho, I. Kodama, J. Toyama, and K. Yamada Effects of bepridil on the electrophysiological properties of guinea-pig ventricular muscles Br J Pharmacol 81 1984 589 597
15. A. Tamura, T. Ogura, H. Uemura, Y. Reien, T. Kishimoto, T. Nagai, I. Komuro, M. Miyazaki, and H. Nakaya Effects of antiarrhythmic drugs on the hyperpolarization-activated cyclic nucleotide-gated channel current J Pharmacol Sci 110 2009 150 159
16. F. Berger, U. Borchard, and D. Hafner Effects of the calcium entry blocker bepridil on repolarizing and pacemaker currents in sheep cardiac Purkinje fibres Naunyn Schmiedebergs Arch Pharmacol 339 1989 638 646