Evaluating the expression and diagnostic value of human epididymis protein 4 (HE4) in small cell lung cancer

Tumor Biology

Volumn 35, Issue 7, 2014, Pages 6847-6853

  Wang, Ximing ^a,b   Fan, Yahong ^c   Wang, Jinliang ^c   Wang, Huaming ^b   Liu, Wenchao ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b BEIJING 302 HOSPITAL   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Biomarker; Diagnosis; HE4; SCLC

Indexed keywords

CARBOPLATIN; ETOPOSIDE; HUMAN EPIDIDYMIS PROTEIN 4; PLATINUM; TEMOZOLOMIDE;

ADULT; ARTICLE; CANCER DIAGNOSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG SMALL CELL CANCER; MALE; MIDDLE AGED; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; PROTEINS; SMALL CELL LUNG CARCINOMA;

EID: 84904997092     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-1943-8     Document Type: Article

References (16)

1. Jemal A, Thun MJ, Ries LA, Howe HL, Weir HK, Center MM, et al. Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control. J Natl Cancer Inst. 2008;100(23):1672-94. doi:10.1093/jnci/djn389.
2. van Meerbeeck JP, Fennell DA, De Ruysscher DK. Small-cell lung cancer. Lancet. 2011;378(9804):1741-55. doi:10.1016/S0140-6736(11)60165-7.
3. Chapman CJ, Thorpe AJ, Murray A, Parsy-Kowalska CB, Allen J, Stafford KM, et al. Immunobiomarkers in small cell lung cancer: potential early cancer signals. Clin Cancer Res Off J Am Assoc Cancer Res. 2011;17(6):1474-80. doi:10.1158/1078-0432.CCR-10-1363.
4. Brower V. Biomarker studies abound for early detection of lung cancer. J Natl Cancer Inst. 2009;101(1):11-3. doi:10.1093/jnci/djn483.
5. Liu W, Yang J, Chi PD, Zheng X, Dai SQ, Chen H, et al. Evaluating the clinical significance of serum HE4 levels in lung cancer and pulmonary tuberculosis. Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis. 2013;17(10):1346-53. doi:10.5588/ijtld.13.0058.
6. Hellstrom I, Hellstrom KE. fTwo novel biomarkers, mesothelin and HE4, for diagnosis of ovarian carcinoma. Expert Opin Med Diagn. 2011;5(3):227-40. doi:10.1517/17530059.2011.559459.
7. Chang X, Ye X, Dong L, Cheng H, Cheng Y, Zhu L, et al. Human epididymis protein 4 (HE4) as a serum tumor biomarker in patients with ovarian carcinoma. Int J Gynecol Cancer Off J Int Gynecol Cancer Soc. 2011;21(5):852-8. doi:10.1097/IGC.0b013e31821a3726.
8. Yamashita S, Tokuishi K, Hashimoto T, Moroga T, Kamei M, Ono K, et al. Prognostic significance of HE4 expression in pulmonary adenocarcinoma. Tumour Biol J Int Soc Oncodev Biol Med. 2011;32(2):265-71. doi:10.1007/s13277-010-0118- 5.
9. Iwahori K, Suzuki H, Kishi Y, Fujii Y, Uehara R, Okamoto N, et al. Serum HE4 as a diagnostic and prognostic marker for lung cancer. Tumour Biol J Int Soc Oncodev Biol Med. 2012;33(4):1141-9. doi:10.1007/s13277-012-0356-9.
10. Micke P, Faldum A, Metz T, Beeh KM, Bittinger F, Hengstler JG, et al. Staging small cell lung cancer: Veterans Administration Lung Study Group versus International Association for the Study of Lung Cancer - what limits limited disease? Lung Cancer. 2002;37(3):271-6. (Pubitemid 35286725)
11. Chhikara N, Saraswat M, Tomar AK, Dey S, Singh S, Yadav S. Human epididymis protein-4 (HE-4): a novel cross-class protease inhibitor. PLoS One. 2012;7(11):e47672. doi:10.1371/journal.pone.0047672.
12. Bingle L, Cross SS, High AS, Wallace WA, Rassl D, Yuan G, et al. WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung. Respir Res. 2006;7:61. doi:10.1186/1465-9921-7-61.
13. Galgano MT, Hampton GM, Frierson Jr HF. Comprehensive analysis of HE4 expression in normal and malignant human tissues. Mod Pathol Off J U S Can Acad Pathol Inc. 2006;19(6):847-53. doi:10.1038/modpathol.3800612. (Pubitemid 43780455)
14. Okamura K, Takayama K, Izumi M, Harada T, Furuyama K, Nakanishi Y. Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer. Lung Cancer. 2013;80(1):45-9. doi:10.1016/j.lungcan.2013.01.002.
15. Seemann MD, Beinert T, Furst H, Fink U. An evaluation of the tumourmarkers, carcinoembryonic antigen (CEA), cytokeratin marker (CYFRA 21-1) and neuron-specific enolase (NSE) in the differentiation of malignant from benign solitary pulmonary lesions. Lung Cancer. 1999;26(3):149-55. (Pubitemid 30114217)
16. Ghosh I, Bhattacharjee D, Das AK, Chakrabarti G, Dasgupta A, Dey SK. Diagnostic role of tumour markers CEA, CA15-3, CA19-9 and CA125 in lung cancer. Indian J Clin Biochem IJCB. 2013;28(1):24-9. doi:10.1007/s12291-012-0257-0.