Synthetic reactions with rare taccalonolides reveal the value of C-22,23 epoxidation for microtubule stabilizing potency

Journal of Medicinal Chemistry

Volumn 57, Issue 14, 2014, Pages 6141-6149

  Peng, Jiangnan ^a,b   Risinger, April L ^a,b   Li, Jing ^a   Mooberry, Susan L ^a,b  

^a University of Texas Health Science Center   (United States)

^b University of Texas Health Science Center at San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; EPOXIDE; KETONE; STABILIZING AGENT; TACCALONOLIDE AA EPOXIDE; TACCALONOLIDE AB EPOXIDE; TACCALONOLIDE AD EPOXIDE; TACCALONOLIDE AI; TACCALONOLIDE AI EPOXIDE; TACCALONOLIDE AN EPOXIDE; TACCALONOLIDE DERIVATIVE; TACCALONOLIDE E EPOXIDE; TACCALONOLIDE R EPOXIDE; TACCALONOLIDE T EPOXIDE; TACCALONOLIDE Z EPOXIDE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; EPOXIDATION; FEMALE; HUMAN; HUMAN CELL; IC 50; MICROTUBULE; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL PROLIFERATION; DIOSCOREACEAE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; EPOXY COMPOUNDS; FEMALE; HELA CELLS; HUMANS; MICE; MICE, NUDE; MICROTUBULES; MOLECULAR CONFORMATION; NEOPLASMS, EXPERIMENTAL; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84904992258     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500619j     Document Type: Article

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