Exacerbation of benign familial neonatal epilepsy induced by massive doses of phenobarbital and midazolam

Pediatric Neurology

Volumn 51, Issue 2, 2014, Pages 259-261

  Maeda, Tomoki ^a   Shimizu, Miki ^a   Sekiguchi, Kazuhito ^a   Ishii, Atsushi ^b   Ihara, Yukiko ^b   Hirose, Shinichi ^b   Izumi, Tatsuro ^a  

^a OITA UNIVERSITY   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

Author keywords

amplitude integrated electroencephalography; benign familial neonatal epilepsy; midazolam; paradoxical exacerbation; phenobarbital; uncoupling phenomenon

Indexed keywords

DIAZEPAM; MIDAZOLAM; PHENOBARBITAL; BENZODIAZEPINE RECEPTOR AFFECTING AGENT;

ANTICONVULSANT THERAPY; ARTICLE; ASSISTED VENTILATION; BENIGN CHILDHOOD EPILEPSY; BRAIN DISEASE; CASE REPORT; CONSCIOUSNESS; CONTINUOUS INFUSION; DISEASE EXACERBATION; DRUG BLOOD LEVEL; ELECTROENCEPHALOGRAPHY; FEMALE; HUMAN; NEWBORN; PRIORITY JOURNAL; SMALL FOR DATE INFANT; CHEMICALLY INDUCED; EPILEPSY, BENIGN NEONATAL; GENETICS; PATHOPHYSIOLOGY; SEIZURE;

ELECTROENCEPHALOGRAPHY; EPILEPSY, BENIGN NEONATAL; FEMALE; GABA MODULATORS; HUMANS; MIDAZOLAM; PHENOBARBITAL; SEIZURES;

EID: 84904913257     PISSN: 08878994     EISSN: 18735150     Source Type: Journal    
DOI: 10.1016/j.pediatrneurol.2014.04.004     Document Type: Article

References (13)

1. C. Biervert, B.C. Schroeder, C. Kubisch, S.F. Berkovic, P. Propping, and T.J. Jentsch et al. A potassium channel mutation in neonatal human epilepsy Science 279 1998 403 406
2. N.A. Singh, C. Charlier, D. Stauffer, B.R. DuPont, R.J. Leach, and R. Melis et al. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns Nat Genet 18 1998 25 29
3. M. Okada, K. Wada, A. Kamata, T. Murakami, G. Zhu, and S. Kaneko Impaired M-current and neuronal excitability Epilepsia 43 Suppl 9 2002 36 38
4. R. Nardou, D.C. Ferrari, and Y. Ben-Ari Mechanisms and effects of seizures in the immature brain Semin Fetal Neonatal Med 18 2013 175 184
5. J. Glykys, V.I. Dzhala, K.V. Kuchibhotla, G. Feng, T. Kuner, and G. Augustine et al. Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures Neuron 63 2009 657 672
6. M. Komatsu, A. Okumura, K. Matsui, T. Kitamura, T. Sato, and T. Shimizu et al. Clustered subclinical seizures in a patient with acute encephalopathy with biphasic seizures and late reduced diffusion Brain Dev 32 2010 472 476
7. S.E. Heron, K. Cox, B.E. Grinton, S.M. Zuberi, S. Kivity, and Z. Afawi et al. Deletions or duplications in KCNQ2 can cause benign familial neonatal seizures J Med Genet 44 2007 791 796
8. M. Kato, T. Yamagata, M. Kubota, H. Arai, S. Yamashita, and T. Nakagawa et al. Clinical spectrum of early onset epileptic encephalopathies caused by KCNQ2 mutation Epilepsia 54 2013 1282 1287
9. R. Nardou, S. Yamamoto, G. Chazal, A. Bhar, N. Ferrand, and O. Dulac et al. Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital Brain 134 Pt 4 2011 987 1002
10. G.B. Boylan, J.M. Rennie, R.M. Pressler, G. Wilson, M. Morton, and C.D. Binnie Phenobarbitone, neonatal seizures, and video-EEG Arch Dis Child Fetal Neonatal Ed 86 2002 F165 F170
11. S. Weckhuysen, S. Mandelstam, A. Suls, D. Audenaert, T. Deconinck, and L.R. Claes et al. KCNQ2 encephalopathy: emerging phenotype of a neonatal epileptic encephalopathy Ann Neurol 71 2012 15 25
12. R. Borgatti, C. Zucca, A. Cavallini, M. Ferrario, C. Panzeri, and P. Castaldo et al. A novel mutation in KCNQ2 associated with BFNC, drug resistant epilepsy, and mental retardation Neurology 63 2004 57 65
13. O.K. Steinlein, C. Conrad, and B. Weidner Benign familial neonatal convulsions: always benign? Epilepsy Res 73 2007 245 249