Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders

European Archives of Psychiatry and Clinical Neuroscience

Volumn 264, Issue 5, 2014, Pages 459-463

  Schaefer, Carola ^a,b   Enning, Frank ^a   Mueller, Juliane K ^a   Bumb, J Malte ^a   Rohleder, Cathrin ^a   Odorfer, Thorsten M ^a   Klosterkötter, Joachim ^b   Hellmich, Martin ^b   Koethe, Dagmar ^a,c   Schmahl, Christian ^d   Bohus, Martin ^d   Leweke, F Markus ^a  

^a MEDICAL FACULTY MANNHEIM HEIDELBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

2 AG; Anandamide; Borderline personality disorder; Disturbance of emotion regulation; Endocannabinoids; Fatty acid ethanolamides; Posttraumatic stress disorder

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ANANDAMIDE; FATTY ACID; FATTY ACID ETHANOLAMIDE; N OLEOYLETHANOLAMINE; PALMIDROL; UNCLASSIFIED DRUG; 2-ARACHIDONYLGLYCEROL; ACYLGLYCEROL; AMIDE; ARACHIDONIC ACID DERIVATIVE; ENDOCANNABINOID; ETHANOLAMINE DERIVATIVE; PALMITIC ACID DERIVATIVE;

ADULT; ARTICLE; BLOOD LEVEL; BORDERLINE STATE; CLINICAL ARTICLE; CONTROLLED STUDY; EMOTIONALITY; FEMALE; HUMAN; MALE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PSYCHOMETRY; BLOOD; MIDDLE AGED; PROSPECTIVE STUDY; PSYCHOLOGICAL RATING SCALE; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

ADULT; ARACHIDONIC ACIDS; BORDERLINE PERSONALITY DISORDER; ENDOCANNABINOIDS; ETHANOLAMINES; FATTY ACIDS; FEMALE; GLYCERIDES; HUMANS; MALE; MIDDLE AGED; PALMITIC ACIDS; POLYUNSATURATED ALKAMIDES; PROSPECTIVE STUDIES; PSYCHIATRIC STATUS RATING SCALES; SEVERITY OF ILLNESS INDEX; STRESS DISORDERS, POST-TRAUMATIC; YOUNG ADULT;

EID: 84904857210     PISSN: 09401334     EISSN: 14338491     Source Type: Journal    
DOI: 10.1007/s00406-013-0470-8     Document Type: Article

References (17)

1. Alger BE, Kim J (2011) Supply and demand for endocannabinoids. Trends Neurosci 34:304-315
2. Bandelow B, Schmahl C, Falkai P, Wedekind D (2010) Borderline personality disorder: a dysregulation of the endogenous opioid system? Psychol Rev 117:623-636
3. Cutajar MC, Mullen PE, Ogloff JR, Thomas SD, Wells DL, Spataro J (2010) Psychopathology in a large cohort of sexually abused children followed up to 43 years. Child Abuse Negl 34:813-822
4. Galve-Roperh I, Palazuelos J, Aguado T, Guzman M (2009) The endocannabinoid system and the regulation of neural development: potential implications in psychiatric disorders. Eur Arch Psychiatry Clin Neurosci 259:371-382
5. Giuffrida A, Leweke FM, Gerth CW, Schreiber D, Koethe D, Faulhaber J, Klosterkötter J, Piomelli D (2004) Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms. Neuropsychopharmacology 29:2108-2114 (Pubitemid 39486563)
6. Green JG, McLaughlin KA, Berglund PA, Gruber MJ, Sampson NA, Zaslavsky AM, Kessler RC (2010) Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication i: associations with first onset of dsm-iv disorders. Arch Gen Psychiatry 67:113-123
7. Hauer D, Schelling G, Gola H, Campolongo P, Morath J, Roozendaal B, Hamuni G, Karabatsiakis A, Atsak P, Vogeser M, Kolassa IT (2013) Plasma concentrations of endocannabinoids and related primary fatty acid amides in patients with post-traumatic stress disorder. PLoS ONE 8:e62741
8. Jumpertz R, Guijarro A, Pratley RE, Piomelli D, Krakoff J (2011) Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure. J Clin Endocrinol Metab 96:787-791
9. Kathuria S, Gaetani S, Fegley D, Valino F, Duranti A, Tontini A, Mor M, Tarzia G, La Rana G, Calignano A, Giustino A, Tattoli M, Palmery M, Cuomo V, Piomelli D (2003) Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 9:76-81 (Pubitemid 36098263)
10. Krause-Utz A, Schmahl C (2010) Neurobiological differentiation between borderline patients with and without post-traumatic stress disorders. Eur Psychiatr Rev 3:63-68
11. Leweke FM, Piomeli D, Pahlisch F, Muhl D, Gerth CW, Hoyer C, Klosterkötter J, Hellmich M, Koethe D (2012) Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Transl Psychiatry 2:e94
12. Lutz B (2007) The endocannabinoid system and extinction learning. Mol Neurobiol 36:92-101
13. Marsicano G, Wotjak CT, Azad SC, Bisogno T, Rammes G, Cascio MG, Hermann H, Tang J, Hofmann C, Zieglgansberger W, Di Marzo V, Lutz B (2002) The endogenous cannabinoid system controls extinction of aversive memories. Nature 418:530-534 (Pubitemid 34851398)
14. Neumeister A, Normandin MD, Pietrzak RH, Piomelli D, Zheng MQ, Gujarro-Anton A, Potenza MN, Bailey CR, Lin SF, Najafzadeh S, Ropchan J, Henry S, Corsi-Travali S, Carson RE, Huang Y (2013) Elevated brain cannabinoid cb receptor availability in post-traumatic stress disorder: a positron emission tomography study. Mol Psychiatry 18:1034-1040
15. Pardini M, Krueger F, Koenigs M, Raymont V, Hodgkinson C, Zoubak S, Goldman D, Grafman J (2012) Fatty-acid amide hydrolase polymorphisms and post-traumatic stress disorder after penetrating brain injury. Transl Psychiatry 2:e75
16. Schneider P, Hannusch C, Schmahl C, Bohus M, Spanagel R, Schneider M (2013) Adolescent peer-rejection persistently alters pain perception and cb1 receptor expression in female rats. Eur Neuropsychopharmacol. doi:10.1016/j.euroneuro.2013.04.004
17. Taber KH, Hurley RA (2009) Endocannabinoids: stress, anxiety, and fear. J Neuropsychiatry Clin Neurosci 21(iv):109-113