Vitamin D receptor (VDR) polymorphisms and severe RSV bronchiolitis: A systematic review and meta-analysis

Pediatric Pulmonology

Volumn 49, Issue 8, 2014, Pages 790-799

  McNally, J Dayre ^a   Sampson, Margaret ^a   Matheson, Loren A ^a   Hutton, Brian ^b   Little, Julian ^c  

^a CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

pediatrics; risk factors; vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; VITAMIN D; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; VDR PROTEIN, HUMAN;

ALLELE; DISEASE SEVERITY; DNA POLYMORPHISM; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HUMAN; INFECTION RISK; LOWER RESPIRATORY TRACT INFECTION; META ANALYSIS (TOPIC); PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL VIRUS INFECTION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMATIC REVIEW; VIRAL BRONCHIOLITIS; VITAMIN D DEFICIENCY; GENETIC PREDISPOSITION; GENETICS; META ANALYSIS; SEVERITY OF ILLNESS INDEX;

ALLELES; BRONCHIOLITIS, VIRAL; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CALCITRIOL; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; SEVERITY OF ILLNESS INDEX;

EID: 84904801792     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.22877     Document Type: Review

References (69)

1. Nair H, Verma VR, Theodoratou E, Zgaga L, Huda T, Simoes EA, Wright PF, Rudan I, Campbell H,. An evaluation of the emerging interventions against Respiratory Syncytial Virus (RSV)-associated acute lower respiratory infections in children. BMC Public Health 2011; 11: S30.
2. Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med 2009; 360: 588-598.
3. Glezen WP, Taber LH, Frank AL, Kasel JA,. Risk of primary infection and reinfection with respiratory syncytial virus. Am J Dis Child 1986; 140: 543-546. (Pubitemid 16120909)
4. Henrickson KJ, Hoover S, Kehl KS, Hua W,. National disease burden of respiratory viruses detected in children by polymerase chain reaction. Pediatr Infect Dis J 2004; 23: S11-S18. (Pubitemid 38168906)
5. Simoes EA, Carbonell-Estrany X,. Impact of severe disease caused by respiratory syncytial virus in children living in developed countries. Pediatr Infect Dis J 2003; 22: S13-S18; discussion S18-S20.
6. Ranmuthugala G, Brown L, Lidbury B,. Respiratory syncytial virus-the unrecognised cause of health and economic burden among young children in Australia. Commun Dis Intell Q Rep 2011; 35: 177-184.
7. Stang P, Brandenburg N, Carter B,. The economic burden of respiratory syncytial virus-associated bronchiolitis hospitalizations. Arch Pediatr Adolesc Med 2001; 155: 95-96. (Pubitemid 32047400)
8. Shay D, Holman R, Newman R,. Bronchiolitis-associated hospitalizations among US children 1980-1996. JAMA 1999; 282: 1440-1446.
9. Hyvärinen M, Piippo-Savolainen E, Korhonen K, Korppi M,. Teenage asthma after severe infantile bronchiolitis or pneumonia. Acta Paediatr 2005; 94: 1378-1383. (Pubitemid 41510645)
10. Stein RT, Sherrill D, Morgan WJ, Holberg CJ, Halonen M, Taussig LM, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 1999; 354: 541-545. (Pubitemid 29381367)
11. Peck AJ, Holman RC, Curns AT, Lingappa JR, Cheek JE, Singleton RJ, et al. Lower respiratory tract infections among American Indian and alaska native children and the general population of U.S. children. Pediatr Infect Dis J 2005; 24: 342-351. (Pubitemid 40525343)
12. Wainwright C,. Acute viral bronchiolitis in children-a very common condition with few therapeutic options. Paediatr Respir Rev 2010; 11: 39-45; quiz 45.
13. Weisman LE,. Populations at risk for developing respiratory syncytial virus and risk factors for respiratory syncytial virus severity: infants with predisposing conditions. Pediatr Infect Dis J 2003; 22: S33-S37.
14. Morris S, Dzolganovski B, Beyene J, Sung L,. A meta-analysis of the effect of antibody therapy for the prevention of severe respiratory syncytial virus infection. BMC Infect Dis 2009; 9: 106.
15. Blanken MO, Rovers MM, Molenaar JM, Winkler-Seinstra PL, Meijer A, Kimpen JLL, et al. Respiratory syncytial virus and recurrent wheeze in healthy preterm infants. N Engl J Med 2013; 368: 1791-1799.
16. Village EG,. From the American Academy of pediatrics: policy statements-modified recommendations for use of palivizumab for prevention of respiratory syncytial virus infections. Pediatrics 2009; 124: 1694-1701.
17. Butt ML, Symington A, Janes M, Elliott L, Steele S, Paes BA,. The impact of prophylaxis on paediatric intensive care unit admissions for RSV infection: a retrospective, single-centre study. Eur J Pediatr 2011; 170: 907-913.
18. Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, et al. Epidemic influenza and vitamin D. Epidemiol Infect 2006; 134: 1129-1140. (Pubitemid 44614932)
19. Muhe L, Lulseged S, Mason KE, Simoes EA,. Case-control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children. Lancet 1997; 349: 1801-1804. (Pubitemid 27257557)
20. Najada AS, Habashneh MS, Khader M,. The frequency of nutritional rickets among hospitalized infants and its relation to respiratory diseases. J Trop Pediatr 2004; 50: 364-368. (Pubitemid 40017231)
21. Banajeh SM,. Outcome for children under 5 years hospitalized with severe acute lower respiratory tract infections in Yemen: a 5 year experience. J Trop Pediatr 1998; 44: 343-346. (Pubitemid 29008200)
22. Roth DE, Shah R, Black RE, Baqui AH,. Vitamin D status and acute lower respiratory infection in early childhood in Sylhet, Bangladesh. Acta Paediatr 2010; 99: 389-393.
23. Roth DE, Jones AB, Prosser C, Robinson JL, Vohra S,. Vitamin D status is not associated with the risk of hospitalization for acute bronchiolitis in early childhood. Eur J Clin Nutr 2009; 63: 297-299.
24. McNally J, Leis K, Matheson LA, Karuananyake C, Sankaran K, Rosenberg AM,. Vitamin D deficiency in young children with severe acute lower respiratory infection. Pediatr Pulmonol 2009; 44: 981-988.
25. Wayse V, Yousafzai A,. Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5 y. Eur J Clin Nutr 2004; 58: 563-567. (Pubitemid 38500124)
26. Camargo CA, Ingham T, Wickens K, Thadhani R, Silvers KM, Epton MJ, et al. Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics 2011; 127: e180-e187.
27. Belderbos ME, Houben ML, Wilbrink B, Lentjes E, Bloemen EM, Kimpen JLL, et al. Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Pediatrics 2011; 127: e1513-e1520.
28. Holick MF,. Vitamin D deficiency. N Engl J Med 2007; 357: 266-281.
29. Shoback D,. Clinical practice. Hypoparathyroidism. N Engl J Med 2008; 359: 391-403.
30. Rukin N, Strange R,. What are the frequency, distribution, and functional effects of vitamin D receptor polymorphisms as related to cancer risk ? Nutr Rev 2008; 65: S96- S101.
31. Thomsen SF, Stensballe LG, Skytthe A, Kyvik KO, Backer V, Bisgaard H,. Increased concordance of severe respiratory syncytial virus infection in identical twins. Pediatrics 2008; 121: 493-496.
32. Valdivielso JM, Fernandez E,. Vitamin D receptor polymorphisms and diseases. Clin Chim Acta 2006; 371: 1-12. (Pubitemid 44162891)
33. Nejentsev S, Godfrey L, Snook H, Rance H, Nutland S, Walker NM, et al. Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene. Hum Mol Genet 2004; 13: 1633-1639. (Pubitemid 39136719)
34. Jurutka PW, Remus LS, Whitfield GK, Thompson PD, Hsieh JC, Zitzer H, et al. The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Mol Endocrinol 2000; 14: 401-420. (Pubitemid 32260532)
35. Egan JB, Thompson PA, Vitanov MV, Bartik L, Jacobs ET, Haussler MR, et al. Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor Fok I polymorphism collectively modulate beta-catenin activity in colon cancer cells. Mol Carcinog 2009; 49: 337-352.
36. Gross C, Krishnan A, Malloy P, Eccleshall T, Zhao X, Feldman D,. The vitamin D receptor gene start codon polymorphism: a functional analysis of FokI variants. J Bone Miner Res 1998; 13: 1691-1699. (Pubitemid 28491998)
37. Ji G-R, Yao M, Sun C-Y, Li Z-H, Han Z,. BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and risk of fracture in Caucasians: a meta-analysis. Bone 2010; 47: 681-686.
38. Lee YH, Bae S-C, Choi SJ, Ji JD, Song GG,. Associations between vitamin D receptor polymorphisms and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. Mol Biol Rep 2011; 38: 3643-3651.
39. Zhou H, Xu C, Gu M,. Vitamin D receptor (VDR) gene polymorphisms and Graves' disease: a meta-analysis. Clin Endocrinol 2009; 70: 938-945.
40. Mocellin S, Nitti D,. Vitamin D receptor polymorphisms and the risk of cutaneous melanoma: a systematic review and meta-analysis. Cancer 2008; 113: 2398-2407.
41. Raimondi S, Johansson H, Maisonneuve P, Gandini S,. Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Carcinogenesis 2009; 30: 1170-1180.
42. Gao L, Tao Y, Zhang L,. Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and meta-analysis. Int J Tuberc Lung Dis 2010; 14: 15.
43. Raghavan S, Alagarasu K, Selvaraj P,. Immunogenetics of HIV and HIV associated tuberculosis. Tuberculosis 2012; 92: 18-30.
44. Aslan S, Akil I, Aslan G, Onay H, Ozyurt BC, Ozkinay F,. Vitamin D receptor gene polymorphism in children with urinary tract infection. Pediatr Nephrol 2011; 27: 417-421.
45. Moher D, Liberati A, Tetzlaff J, Altman DG,. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009; 6: e1000097.
46. Sampson M, McGowan J, Cogo E, Grimshaw J, Moher D, Lefebvre C,. An evidence-based practice guideline for the peer review of electronic search strategies. J Clin Epidemiol 2009; 62: 944-952.
47. Hindorff L, MacArthur J, Morales J, Junkins H, Hall P, Klemm A, et al. A catalog of published genome-wide association studies. http://www/genome.gov/ gwastudies (accessed 16 Jan 2013).
48. Little J, Higgins JP, Ioannidis JP, Moher D, Gagnon F, Von Elm E, et al. Strengthening the reporting of genetic association studies (STREGA)-an extension of the STROBE statement. Eur J Clin Invest 2009; 39: 247-266.
49. Wells G, Shea B, O'Connell D, Peterson J, Welch V, Losos M,. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. http://www.ohri.ca/programs/clinical-epidemiology/oxford.htm
50. Lundh A, Gøtzsche PC,. Recommendations by Cochrane Review Groups for assessment of the risk of bias in studies. BMC Med Res Methodol 2008; 8: 22.
51. Bauer T, Bouman HJ, Van Werkum JW, Ford NF, Ten Berg JM, Taubert D,. Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis. Br Med J 2011; 343: d4588-d4588.
52. Somkrua R, Eickman EE, Saokaew S, Lohitnavy M, Chaiyakunapruk N,. Association of HLA-B 5801 allele and allopurinol-induced Stevens Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis. BMC Med Genet 2011; 12: 118.
53. Chanock SJ, Manolio T, Boehnke M, Boerwinkle E, Hunter DJ, Thomas G, et al. Replicating genotype-phenotype associations. Nature 2007; 447: 655-660. (Pubitemid 46889722)
54. Little J, Higgins JPT, (editors). The HuGENet™ HuGE Review Handbook version 1.0. http://www.hugenet.ca.
55. Little J, Bradley L, Bray M, Clyne M,. Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations. Am J Epidemiol 2002; 157: 784-791.
56. Flores C, Pino-Yanes MDM, Villar J,. A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury. Crit Care 2008; 12: R130.
57. Rodriguez S, Gaunt TR, Day INM,. Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am J Epidemiol 2009; 169: 505-514.
58. Salanti G, Amountza G, Ntzani EE, Ioannidis JP,. Hardy-Weinberg equilibrium in genetic association studies: an empirical evaluation of reporting, deviations, and power. Eur J Hum Genet 2005; 13: 840-848. (Pubitemid 40946083)
59. Egger M, Schneider M, Davey Smith G,. Spurious precision? Meta-analysis of observational studies. Br Med J 1998; 316: 140-144. (Pubitemid 28121116)
60. Roth DE, Jones AB, Prosser C, Robinson JL, Vohra S,. Vitamin D receptor polymorphisms and the risk of acute lower respiratory tract infection in early childhood. J Infect Dis 2008; 197: 676-680. (Pubitemid 351364466)
61. Bhalla AK, Amento EP, Krane SM,. Differential effects of 1,25-dihydroxyvitamin D3 on human lymphocytes and monocyte/macrophages: inhibition of interleukin-2 and augmentation of interleukin-1 production. Cell Immunol 1986; 98: 311-322. (Pubitemid 16112035)
62. Bhalla AK, Amento EP, Clemens TL, Holick MF, Krane SM,. Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. J Clin Endocrinol Metab 1983; 57: 1308-1310. (Pubitemid 14209439)
63. Abu-Amer Y, Bar-Shavit Z,. Impaired bone marrow-derived macrophage differentiation in vitamin D deficiency. Cell Immunol 1993; 151: 356-368. (Pubitemid 23325458)
64. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006; 311: 1770-1773.
65. Liu PT, Stenger S, Tang DH, Modlin RL,. Cutting edge: vitamin D-mediated human antimicrobial activity against myocbacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol 2007; 179: 2060.
66. Karatekin G, Kaya A, Salihoǧlu O, Balci H, Nuhoǧlu A,. Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Eur J Clin Nutr 2009; 63: 473-477.
67. Shirts BH, Howard MT, Hasstedt SJ, Nanjee MN, Knight S, Carlquist JF, et al. Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol. Atherosclerosis 2012; 222: 167-174.
68. Liu X, Wang G, Hong X, Wang D, Tsai H-J, Zhang S, et al. Gene-vitamin D interactions on food sensitization: a prospective birth cohort study. Allergy 2011; 66: 1442-1448.
69. Du R, Litonjua AA, Tantisira KG, Lasky-Su J, Sunyaev SR, Klanderman BJ, et al. Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations. J Allergy Clin Immunol 2012; 129: 368-373, 373.e1-373.e5.