Gene therapy restores vision and delays degeneration in the CNGB1−/− mouse model of retinitis pigmentosa

Advances in Experimental Medicine and Biology

Volumn 801, Issue , 2014, Pages 733-739

  Michalakis, Stylianos ^a   Koch, Susanne ^a   Sothilingam, Vithiyanjali ^b   Garrido, Marina Garcia ^b   Tanimoto, Naoyuki ^b   Schulze, Elisabeth ^a   Becirovic, Elvir ^a   Koch, Fred ^a   Seide, Christina ^b   Beck, Susanne C ^b   Seeliger, Mathias W ^b   Mühlfriedel, Regine ^b   Biel, Martin ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Adenoassociated virus vector; Cyclic nucleotide gated channel; Gene replacement; Gene therapy; Retinitis pigmentosa; Rod photoreceptor

Indexed keywords

CYCLIC NUCLEOTIDE GATED CHANNEL; CYCLIC NUCLEOTIDE GATED CHANNEL B1 SUBUNIT; UNCLASSIFIED DRUG; CNGB1 PROTEIN, MOUSE; NERVE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CONTROLLED STUDY; DRUG EFFICACY; ELECTRORETINOGRAM; GENE MUTATION; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MAZE TEST; MOLECULAR CLONING; MORPHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA DEGENERATION; RETINA ROD; RETINITIS PIGMENTOSA; VIRAL GENE THERAPY; VISION; ADENO ASSOCIATED VIRUS; ANIMAL; CONVALESCENCE; DISEASE MODEL; ELECTRORETINOGRAPHY; GENETICS; PHYSIOLOGY;

ADENO-ASSOCIATED VIRUS; MUS;

ANIMALS; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; MAZE LEARNING; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; RECOVERY OF FUNCTION; RETINAL DEGENERATION; RETINAL ROD PHOTORECEPTOR CELLS; RETINITIS PIGMENTOSA; VISION, OCULAR;

EID: 84904787278     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-1-4614-3209-8_92     Document Type: Article

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