A silent revolution in chromosome biology

Nature Reviews Molecular Cell Biology

Volumn 15, Issue 7, 2014, Pages 431-

  Uhlmann, Frank ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CONDENSIN;

BIOLOGY; CHROMATIN; CHROMOSOME; CRYOELECTRON MICROSCOPY; ELASTICITY; ENZYME THERAPY; HUMAN; MICROPIPETTE; MITOSIS; NOTE; NUCLEOSOME; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CHROMATIN; CHROMOSOMES; CHROMOSOMES, HUMAN; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; HUMANS; MITOSIS; MULTIPROTEIN COMPLEXES; NUCLEOSOMES;

EID: 84904767565     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm3817     Document Type: Note

References (4)

1. Poirier, M. G. & Marko, J. F. Mitotic chromosomes are chromatin networks without a mechanically contiguous protein scaffold. Proc. Natl Acad. Sci. USA 99, 15393-15397 (2002)
2. König, P. et al. The three-dimensional structure of in vitro reconstituted Xenopus laevis chromosomes by EM tomography. Chromosoma 116, 349-372 (2007)
3. Eltsov, M. et al. Analysis of cryo-electron microscopy images does not support the existence of 30 nm chromatin fibers in mitotic chromosomes in situ. Proc. Natl Acad. Sci. USA 105, 19732-19737 (2008)
4. Nishino, Y. et al. Human mitotic chromosomes consist predominantly of irregularly folded nucleosome fibres without a 30 nm chromatin structure. EMBO J. 31, 1644-1653 (2012)