Overexpression of mitofusin 2 inhibits reactive astrogliosis proliferation in vitro

Neuroscience Letters

Volumn 579, Issue , 2014, Pages 24-29

  Liu, Tao ^a   Xue, Chen chen ^a   Shi, Yu long ^a   Bai, Xiang jun ^a   Li, Zhan fei ^a   Yi, Cheng la ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cell cycle arrest; Mitofusin 2; Reactive astrogliosis

Indexed keywords

ADENOVIRUS VECTOR; GREEN FLUORESCENT PROTEIN; MITOFUSIN 2; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; MITOFUSIN 2 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; ASTROCYTOSIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DOWN REGULATION; HYPERPLASIA; IN VITRO STUDY; NERVE CELL LESION; NERVE FIBER REGENERATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; STARVATION; TUMOR GROWTH; UPREGULATION; WOUND HEALING; WOUND HEALING IMPAIRMENT; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL CYCLE; GLIOSIS; METABOLISM; PATHOLOGY; PHYSIOLOGY; SERUM; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; GLIOSIS; MEMBRANE PROTEINS; MITOCHONDRIAL PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SERUM; WOUND HEALING;

EID: 84904755670     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.07.002     Document Type: Article

References (27)

1. Sofroniew M.V. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 2009, 32:638-647.
2. Karimi-Abdolrezaee S., Billakanti R. Reactive astrogliosis after spinal cord injury-beneficial and detrimental effects. Mol. Neurobiol. 2012, 46:251-264.
3. White R.E., Jakeman L.B. Don't fence me in: harnessing the beneficial roles of astrocytes for spinal cord repair. Restor. Neurol. Neurosci. 2008, 26:197-214.
4. Chen Z., Negra M., Levine A., Ughrin Y., Levine J.M. Oligodendrocyte precursor cells: reactive cells that inhibit axon growth and regeneration. J. Neurocytol. 2002, 31:481-495.
5. de Brito O.M., Scorrano L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 2008, 456:605-610.
6. Chen K., Guo X., Ma D., Guo Y., Li Q., Yang D. Dysregulation of HSG triggers vascular proliferative disorders. Nat. Cell Biol. 2004, 6:872-883.
7. Guo Y., Chen K., Gao W., Li Q., Chen L., Wang G.S. Overexpression of mitofusin 2 inhibited oxidized low-density lipoprotein induced vascular smooth muscle cell proliferation and reduced atherosclerotic lesion formation in rabbit. Biochem. Biophys. Res. Commun. 2007, 363:411-417.
8. Yu H., Guo Y., Mi L., Wang X., Li L., Gao W. Mitofusin 2 inhibits angiotensin II-induced myocardial hypertrophy. J. Cardiovasc. Pharmacol. Ther. 2011, 16:205-211.
9. Tang W., Cui T., Wang B., Wu W. Effect of mitofusin 2 overexpression on the proliferation and apoptosis of high-glucose-induced rat glomerular mesangial cells. J. Nephrol. 2012, 25:1023-1030.
10. Chen K.H., Dasgupta A., Ding J., Indig F.E., Ghosh P., Longo D.L. Role of mitofusin 2 (Mfn2) in controlling cellular proliferation. FASEB J. 2014, 28:382-394.
11. Cheng P., Alberts I., Li X. The role of ERK1/2 in the regulation of proliferation and differentiation of astrocytes in developing brain. Int. J. Dev. Neurosci. 2013, 31:783-789.
12. Kawalec M., Kotruchow K., Kochanski A., Zablocka B. Mitofusin 2 as a crucial peripheral nervous system protein and a common regulator of cell metabolism. Postepy Biochem. 2011, 57:215-221.
13. Skaper S.D., Argentini C., Barbierato M. Culture of neonatal rodent microglia, astrocytes, and oligodendrocytes from cortex and spinal cord. Methods Mol. Biol. 2012, 846:67-77.
14. Chou R.C., Langan T.J. In vitro synchronization of mammalian astrocytic cultures by serum deprivation. Brain Res. Brain Res. Protoc. 2003, 11:162-167.
15. Liu C., Wu Z., Shu C., Li D., Zeng Y., Cui Q. Experimental investigation of HGF inhibiting glial scar in vitro. Cell. Mol. Neurobiol. 2011, 31:259-268.
16. Chi Z., Ma X., Cui G., Li M., Li F. Cinnamtannin B-1 regulates cell proliferation of spinal cord astrocytes and protects the cell from oxygen-glucose serum deprivation/reoxygenation induced apoptosis. Int. J. Mol. Sci. 2013, 14:827-837.
17. Choi I., Kim J., Jeong H.K., Kim B., Jou I., Park S.M. PINK1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced AKT and increased p38 MAPK activation, and downregulation of EGFR. Glia 2013, 61:800-812.
18. Chaturvedi R.K., Flint B.M. Mitochondrial diseases of the brain. Free Radic. Biol. Med. 2013, 63:1-29.
19. Wu V.W., Schwartz J.P. Cell culture models for reactive gliosis: new perspectives. J. Neurosci. Res. 1998, 51:675-681.
20. Yang H., Cheng X., Li J., Yao Q., Ju G. De-differentiation response of cultured astrocytes to injury induced by scratch or conditioned culture medium of scratch-insulted astrocytes. Cell. Mol. Neurobiol. 2009, 29:455-473.
21. McMillian M.K., Thai L., Hong J.S., O'Callaqhan J.P., Pennypacker K.R. Brain injury in a dish: a model for reactive gliosis. Trends Neurosci. 1994, 17:138-142.
22. Cernak I., Stoica B., Byrnes K.R., Di-Giovanni S., Faden A.I. Role of the cell cycle in the pathobiology of central nervous system trauma. Cell Cycle 2005, 4:1286-1293.
23. Jin B., Fu G., Pan H., Cheng X., Zhou L., Lv J. Anti-tumor efficacy of mitofusin-2 in urinary bladder carcinoma. Med. Oncol. 2011, 28:s373-s380.
24. Mandell J.W., VandenBerg S.R. ERK/MAP kinase is chronically activated in human reactive astrocytes. Neuroreport 1999, 10:3567-3572.
25. Lim J.H., Gibbons H.M., O'Carroll S.J., Narayan P.J., Faull R.L., Dragunow M. Extracellular signal-regulated kinase involvement in human astrocyte migration. Brain Res. 2007, 1164:1-13.
26. Mandell J.W., Gocan N.C., Vandenberg S.R. Mechanical trauma induces rapid astroglial activation of ERK/MAP kinase: evidence for a paracrine signal. Glia 2001, 34:283-295.
27. Jiang Z., Zhang Y., Chen X., Lam P.Y., Yang H., Xu Q. Activation of Erk1/2 and Akt in astrocytes under ischemia. Biochem. Biophys. Res. Commun. 2002, 294:726-733.