ADAMTS9 locus associates with increased risk of wet AMD

Acta Ophthalmologica

Volumn 92, Issue 5, 2014, Pages

  Helisalmi, Seppo ^a,b,c   Immonen, Ilkka ^c   Losonczy, Gergely ^d   Resch, Miklos D ^e   Benedek, Szabolcs ^e   Balogh, Istvan ^d   Papp, Andras ^e   Berta, Andras ^d   Uusitupa, Matti ^a   Hiltunen, Mikko ^a,b   Kaarniranta, Kai ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d UNIVERSITY OF DEBRECEN   (Hungary)

^e SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMTS9 GENE; ARTERIOSCLEROSIS; FLUORESCENCE ANGIOGRAPHY; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC LINKAGE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; LETTER; OBESITY; OPTICAL COHERENCE TOMOGRAPHY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; RETINA CELL; RETINA MACULA AGE RELATED DEGENERATION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; SUBRETINAL NEOVASCULARIZATION; WET RETINA MACULA AGE RELATED DEGENERATION; GENETICS; REGULATOR GENE; RISK FACTOR; WET MACULAR DEGENERATION;

ADAM PROTEIN; ADAMTS9 PROTEIN, HUMAN;

ADAM PROTEINS; FLUORESCEIN ANGIOGRAPHY; HUMANS; LOCUS CONTROL REGION; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TOMOGRAPHY, OPTICAL COHERENCE; WET MACULAR DEGENERATION;

EID: 84904738934     PISSN: 1755375X     EISSN: 17553768     Source Type: Journal    
DOI: 10.1111/aos.12341     Document Type: Letter

References (5)

1. Fritsche LG, Chen W, Schu M, et al. (2013): Seven new loci associated with age-related macular degeneration. Nat Genet 45: 433-439.
2. Kaarniranta K, Sinha D, Blasiak J, et al. (2013): Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy 9: 973-984.
3. Kinnunen K, Petrovski G, Moe MC, et al. (2012): Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration. Acta Ophthalmol 90: 299-309.
4. Koo BH, Coe DM, Dixon LJ, et al. (2010): ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells. Am J Pathol 176: 1494-1504.
5. Nischler C, Oberkofler H, Ortner C, et al. (2011): Complement factor H Y402H gene polymorphism and response to intravitreal bevacizumab in exudative age-related macular degeneration. Acta Ophthalmol 89: e344-349.