The effects of erythropoietin signaling on telomerase regulation in non-erythroid malignant and non-malignant cells

Biochemical and Biophysical Research Communications

Volumn 450, Issue 1, 2014, Pages 274-282

  Uziel, Orit ^a   Kanfer, Gil ^a   Beery, Einat ^a   Yelin, Dana ^a   Shepshelovich, Daniel ^a   Bakhanashvili, Mary ^b   Nordenberg, Jardena ^a,c   Lahav, Meir ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c RABIN MEDICAL CENTER   (Israel)

Author keywords

Erythropoietin; Lyn src; Telomerase; Telomeres

Indexed keywords

CISPLATIN; ERYTHROPOIETIN; TELOMERASE;

ARTICLE; CANCER CELL; CELL CYCLE; CELL MIGRATION; CELL PROLIFERATION; CHEMOSENSITIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TELOMERE; TELOMERE SHORTENING;

ERYTHROPOIETIN; LYN-SRC; TELOMERASE; TELOMERES;

CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; ENZYME ACTIVATION; ERYTHROID CELLS; ERYTHROPOIETIN; HUMANS; SARCOMA, EWING; SIGNAL TRANSDUCTION; TELOMERASE; TELOMERE SHORTENING;

EID: 84904720299     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.05.105     Document Type: Article

References (13)

1. A.J. Sytkowski Does erythropoietin have a dark side? Epo signaling and cancer cells Sci. STKE 395 2007 pe38
2. F. Lavelle, J.F. Riou, A. Laoui, and P. Mailliet Telomerase: a therapeutic target for the third millennium? Crit. Rev. Oncol. Hematol. 34 2000 111 126
3. E. Skordalakes Telomerase structure paves the way for new cancer therapies Future Oncol. 5 2009 163 167
4. N. Prade-Houdellier, E. Frébet, and C. Demur et al. Human telomerase is regulated by erythropoietin and transforming growth factor-beta in human erythroid progenitor cells Leukemia 21 2007 2304 2310
5. M. Akiyama, T. Kawano, and Y. Mikami-Terao et al. Erythropoietin activates telomerase through transcriptional and posttranscriptional regulation in human erythroleukemic JAS-REN-A cells Leuk. Res. 35 2011 416 418
6. S. Marcand, V. Brevet, and C. Mann et al. Cell cycle restriction of telomere elongation Curr. Biol. 10 2000 487 490
7. O. Uziel, E. Beery, and V. Dronichev et al. Telomere shortening sensitizes cancer cells to selected cytotoxic agents: in vitro and in vivo studies and putative mechanisms PLoS ONE 5 2010 e9132
8. S. Bougel, B. Lhermitte, and G. Gallagher et al. Methylation of the hTERT promoter: a novel cancer biomarker for leptomeningeal metastasis detection in cerebrospinal fluids Clin. Cancer Res. 19 2013 2216 2223
9. N. Sumaya, H. Hamadmad, and K. Matthew Erythropoietin receptor signal transduction requires protein geranylgeranylation J. Pharmacol. Exp. Ther. 316 2006 403 409
10. A.D. D'Andrea, and L.I. Zon Erythropoietin receptor. Subunit structure and activation J. Clin. Invest. 86 1990 681 687
11. J.N. Ihle Cytokine receptor signaling Nature 19 1995 591 594
12. H. Chin, T. Saito, and A. Arai et al. Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells Biochem. Biophys. Res. Commun. 239 1997 412 417
13. J. Szenajch, G. Wcislo, J.Y. Jeong, C. Szczylik, and L. Feldman The role of erythropoietin and its receptor in growth, survival and therapeutic response of human tumor cells from clinic to bench - a critical review Biochim. Biophys. Acta 2010 1806 82 95