Serum uric acid and its relationship with metabolic syndrome and cardiovascular risk profile in patients with hypertension: Insights from the I-DEMAND study

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 24, Issue 8, 2014, Pages 921-927

  Viazzi, F ^a   Garneri, D ^a   Leoncini, G ^a   Gonnella, A ^a   Muiesan, M L ^b   Ambrosioni, E ^c   Costa, F V ^c   Leonetti, G ^d   Pessina, A C ^e   Trimarco, B ^f   Volpe, M ^g,h   Agabiti Rosei, E ^b   Deferrari, G ^a   Pontremoli, R ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^e UNIVERSITY OF PADOVA   (Italy)

^f UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^g SAPIENZA UNIVERSITY OF ROME   (Italy)

^h IRCCS NEUROMED   (Italy)

Author keywords

Cardiovascular risk; Chronic kidney disease; Hypertension; Metabolic syndrome; Uric acid

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; BIOLOGICAL MARKER; URIC ACID;

ADULT; ARTICLE; BLOOD PRESSURE MONITORING; CARDIOVASCULAR RISK; FEMALE; FRAMINGHAM RISK SCORE; GLOMERULUS FILTRATION RATE; HUMAN; HYPERTENSION; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MICROALBUMINURIA; MIDDLE AGED; MORBIDITY; PREVALENCE; PRIORITY JOURNAL; URIC ACID BLOOD LEVEL; AGED; ALBUMINURIA; BLOOD; BODY MASS; CARDIOVASCULAR DISEASES; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; HYPERURICEMIA; ITALY; MULTIVARIATE ANALYSIS; RENAL INSUFFICIENCY, CHRONIC; RISK FACTOR; STATISTICAL MODEL;

AGED; ALBUMINURIA; BIOLOGICAL MARKERS; BODY MASS INDEX; CARDIOVASCULAR DISEASES; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; HYPERTENSION; HYPERURICEMIA; ITALY; LOGISTIC MODELS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREVALENCE; RENAL INSUFFICIENCY, CHRONIC; RISK FACTORS; URIC ACID;

EID: 84904719669     PISSN: 09394753     EISSN: 15903729     Source Type: Journal    
DOI: 10.1016/j.numecd.2014.01.018     Document Type: Article

References (37)

1. Kim S.Y., Guevara J.P., Kim K.M., Choi H.K., Heitjan D.F., Albert D.A. Hyperuricemia and coronary heart disease: a systematic review and meta-analysis. Arthritis Care Res (Hoboken) 2010, 62:170-180.
2. Obermayr R.P., Temml C., Gutjahr G., Knechtelsdorfer M., Ober bauer R., Klauser-Braun R. Elevated uric acid increases the risk for kidney disease. J Am Soc Nephrol 2008, 19:2407-2413.
3. Silbernagel G., Hoffmann M.M., Grammer T.B., Boehm B.O., März W. Uric acid is predictive of cardiovascular mortality and sudden cardiac death in subjects referred for coronary angiography. Nutr Metab Cardiovasc Dis 2013, 23:46-52.
4. Lazaros G., Tsiachris D., Aznaouridis K., Vlachopoulos C., Tsioufis C., Chrysohoou C., et al. Uric acid in-hospital changes predict mortality in patients with acute myocardial infarction. Nutr Metab Cardiovasc Dis 2013, 23:1202-1209.
5. Savarese G., Ferri C., Trimarco B., Rosano G., Dellegrottaglie S., Losco T., et al. Changes in serum uric acid levels and cardiovascular events: a meta-analysis. Nutr Metab Cardiovasc Dis 2013, 23:707-714.
6. Gami A.S., Witt B.J., Howard D.E., Erwin P.J., Gami L.A., Somers V.K., et al. Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 2007, 49:403-414.
7. Navaneethan S.D., Schold J.D., Kirwan J.P., Arrigain S., Jolly S.E., Poggio E.D., et al. Metabolic syndrome, ESRD, and death in CKD. Clin J Am Soc Nephrol 2013, 8:945-952.
8. Feig D.I. Uric acid and hypertension. Semin Nephrol 2011, 31:441-446.
9. Lin S.D., Tsai D.H., Hsu S.R. Association between serum uric acid level and components of the metabolic syndrome. J Chin Med Assoc 2006, 69:512-516.
10. Viazzi F., Leoncini G., Ratto E., Falqui V., Parodi A., Conti N., et al. Mild hyperuricemia and subclinical renal damage in untreated primary hypertension. Am J Hypertens 2007, 20:1276-1282.
11. Liu P.W., Chang T.Y., Chen J.D. Serum uric acid and metabolic syndrome in Taiwanese adults. Metabolism 2010, 59:802-807.
12. Lim J.H., Kim Y.K., Kim Y.S., Na S.H., Rhee M.Y., Lee M.M. Relationship between serum uric acid levels, metabolic syndrome, and arterial stiffness in korean. Korean Circ J 2010, 40:314-320.
13. Choi H.K., Ford E.S. Prevalence of the metabolic syndrome in individuals with hyperuricemia. Am J Med 2007, 120:442-447.
14. Rodrigues S.L., Baldo M.P., Capingana P., Magalhães P., Dantas E.M., Molina Mdel C., et al. Gender distribution of serum uric acid and cardiovascular risk factors: population based study. Arq Bras Cardiol 2012, 98:13-21.
15. Li Q., Yang Z., Lu B., Wen J., Ye Z., Chen L., et al. Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes. Cardiovasc Diabetol 2011, 10:72.
16. Kim E.S., Kwon H.S., Ahn C.W., Lim D.J., Shin J.A., Lee S.H., et al. Serum uric acid level is associated with metabolic syndrome and microalbuminuria in Korean patients with type 2 diabetes mellitus. J Diabetes Complicat 2011, 25:309-313.
17. Seki S., Tsutsui K., Fujii T., Yamazaki K., Anzawa R., Yoshimura M. Association of uric acid with risk factors for chronic kidney disease and metabolic syndrome in patients with essential hypertension. Clin Exp Hypertens 2010, 32:270-277.
18. Mangge H., Zelzer S., Puerstner P., Schnedl W.J., Reeves G., Postolache T.T., et al. Uric acid best predicts metabolically unhealthy obesity with increased cardiovascular risk in youth and adults. Obesity (Silver Spring) 2013, 21:E71-E77.
19. Weghuber D., Zelzer S., Stelzer I., Paulmichl K., Kammerhofer D., Schnedl W., et al. High risk vs. "metabolically healthy" phenotype in juvenile obesity - neck subcutaneous adipose tissue and serum uric acid are clinically relevant. Exp Clin Endocrinol Diabetes 2013, 121:384-390.
20. Sui X., Church T.S., Meriwether R.A., Lobelo F., Blair S.N. Uric acid and the development of metabolic syndrome in women and men. Metabolism 2008, 57:845-852.
21. Ryu S., Song J., Choi B.Y., Lee S.J., Kim W.S., Chang Y., et al. Incidence and risk factors for metabolic syndrome in Korean male workers, ages 30 to 39. Ann Epidemiol 2007, 17:245-252.
22. Wang J.Y., Chen Y.L., Hsu C.H., Tang S.H., Wu C.Z., Pei D. Predictive value of serum uric acid levels for the diagnosis of metabolic syndrome in adolescents. J Pediatr 2012, 161:753-756.
23. Leoncini G., Viazzi F., Vercelli M., Deferrari G., Pontremoli R. Metabolic syndrome and microalbuminuria predict renal outcome in non-diabetic patients with primary hypertension: the MAGIC study. J Hum Hypertens 2012, 26:149-156.
24. Brodov Y., Behar S., Boyko V., Chouraqui P. Effect of the metabolic syndrome and hyperuricemia on outcome in patients with coronary artery disease (from the Bezafibrate Infarction Prevention Study). Am J Cardiol 2010, 106:1717-1720.
25. Chuang S.Y., Chen J.H., Yeh W.T., Wu C.C., Pan W.H. Hyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort. Int J Cardiol 2012, 154:316-321.
26. Viazzi F., Leoncini G., Vercelli M., Deferrari G., Pontremoli R. Serum uric acid levels predict new-onset type 2 diabetes in hospitalized patients with primary hypertension: the MAGIC study. Diabetes Care 2011, 3(4):126-128.
27. Leoncini G., Viazzi F., Rosei E.A., Ambrosioni E., Costa F.V., Leonetti G., et al. Chronic kidney disease in hypertension under specialist care: the I-DEMAND study. J Hypertens 2010, 28:156-162.
28. Leoncini G., Viazzi F., Agabiti Rosei E., Ambrosioni E., Costa F.V., Leonetti G., et al. Metabolic syndrome and chronic kidney disease in high-risk Italian hypertensive patients: the I-DEMAND study. J Nephrol 2012, 25:63-74.
29. Levey A.S., Stevens L.A., Schmid C.H., Zhang Y.L., Castro A.F., Feldman H.I., et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009, 150:604-612. CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration).
30. Mancia G., De Backer G., Dominiczak A., Cifkova R., Fagard R., Germano G., et al. ESH-ESC Task Force on the Management of Arterial Hypertension. 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial Hypertension. J Hypertens 2007, 25:1751-1762.
31. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001, 285:2486-2497.
32. D'Agostino R.B., Vasan R.S., Pencina M.J., Wolf P.A., Cobain M., Massaro J.M., et al. General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 2008, 117:743-753.
33. Kodama S., Saito K., Yachi Y., Asumi M., Sugawara A., Totsuka K., et al. Association between serum uric acid and development of type 2 diabetes. Diabetes Care 2009, 32:1737-1742.
34. Panero F., Gruden G., Perotto M., Fornengo P., Barutta F., Greco E., et al. Uric acid is not an independent predictor of cardiovascular mortality in type 2 diabetes: a population-based study. Atherosclerosis 2012, 221:183-188.
35. Zoppini G., Targher G., Negri C., Stoico V., Perrone F., Muggeo M., et al. Elevated serum uric acid concentrations independently predict cardiovascular mortality in type 2 diabetic patients. Diabetes Care 2009, 32:1716-1720.
36. Kanbay M., Segal M., Afsar B., Kang D.H., Rodriguez-Iturbe B., Johnson R.J. The role of uric acid in the pathogenesis of human cardiovascular disease. Heart 2013, 99:759-766.
37. Ghaemi-Oskouie F., Shi Y. The role of uric acid as an endogenous danger signal in immunity and inflammation. Curr Rheumatol Rep 2011, 13:160-166.