Immunolocalization of ERK1/2 and p-AKT in normal endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer and their prognostic significance in malignant group

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 179, Issue , 2014, Pages 147-152

  Gungorduk, Kemal ^a   Ertas, Ibrahim Egemen ^a   Sahbaz, Ahmet ^b   Ozvural, Seyfettin ^a   Sarica, Yagmur ^c   Ozdemir, Aykut ^a   Sayhan, Sevil ^a   Gokcu, Mehmet ^a   Yilmaz, Bulent ^a   Sanci, Muzaffer ^a   Inan, Sevinc ^c   Harma, Mehmet ^b   Yildirim, Yusuf ^a  

^a TEPECIK EDUCATION AND RESEARCH HOSPITAL   (Turkey)

^b ZONGULDAK KARAELMAS UNIVERSITY   (Turkey)

^c CELAL BAYAR UNIVERSITY   (Turkey)

Author keywords

Endometrial hyperplasia; Endometrioid endometrial adenocancer; ERK1 2; Immunolocalization; p AKT; Prognosis

Indexed keywords

FORMALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PARAFFIN; PROTEIN KINASE B; MITOGEN ACTIVATED PROTEIN KINASE;

ADULT; ADVANCED CANCER; ADVANCED STAGE ENDOMETRIOID ENDOMETRIAL ADENOCANCER; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; EARLY CANCER; EARLY STAGE ENDOMETRIOID ENDOMETRIAL ADENOCANCER; ENDOMETRIOID CARCINOMA; ENDOMETRIOID ENDOMETRIAL ADENOCANCER; ENDOMETRIUM; ENDOMETRIUM BIOPSY; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; ENZYME PHOSPHORYLATION; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; HYSTERECTOMY; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; LYMPH NODE; LYMPH NODE METASTASIS; LYMPH VESSEL METASTASIS; MENOPAUSE; METASTASIS; MIDDLE AGED; MYOMETRIAL INVASION; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROTEIN EXPRESSION; TUMOR VOLUME; CANCER CLASSIFICATION; CANCER DIAGNOSIS; CANCER SURGERY; CURETTAGE; DIFFERENTIAL DIAGNOSIS; AGED; DISEASE FREE SURVIVAL; ENDOMETRIUM TUMOR; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROGNOSIS;

ADULT; AGED; CARCINOMA, ENDOMETRIOID; DISEASE-FREE SURVIVAL; ENDOMETRIAL HYPERPLASIA; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; PHOSPHORYLATION; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84904705157     PISSN: 03012115     EISSN: 18727654     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2014.05.040     Document Type: Article

References (29)

1. A. Jemal, R. Siegel, J. Xu, and E. Ward Cancer statistics, 2010 CA Cancer J Clin 60 2010 277 300
2. X. Matias-Guiu, L. Catasus, and E. Bussaglia et al. Molecular pathology of endometrial hyperplasia and carcinoma Hum Pathol 32 2001 569 577
3. L. Santarpia, S.M. Lippman, and A.K. El-Naggar Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy Expert Opin Ther Targets 16 2012 103 119
4. A. Carnero, C. Blanco-Aparicio, O. Renner, W. Link, and J.F. Leal The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications Cancer Drug Targets 8 2008 187 198
5. S. Meloche, and J. Pouysségur The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition Oncogene 26 2007 3227 3239
6. J.S. Sebolt-Leopold, and R. Herrera Targeting the mitogen-activated protein kinase cascade to treat cancer Nat Rev Cancer 4 2004 937 947
7. Z. Zhang, D. Zhou, and Y. Lai et al. Estrogen induces endometrial cancer cell proliferation and invasion by regulating the fat mass and obesity-associated gene via PI3K/AKT and MAPK signaling pathways Cancer Lett 319 2012 89 97
8. B.D. Manning, and L.C. Cantley AKT/PKB signaling: navigating downstream Cell 129 2007 1261 1274
9. R.W. Noyes, A.I. Hertig, and J. Rock Dating the endometrial biopsy Fertil Steril 1 1950 3 25
10. R.J. Kurman, P.F. Kaminski, and H.J. Norris The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients Cancer 56 1985 403 412
11. J.L. Hecht, and G.L. Mutter Molecular and pathologic aspects of endometrial carcinogenesis J Clin Oncol 24 2006 4783 4791
12. R.J. Shaw, and L.C. Cantley Ras, PI(3)K and mTOR signalling controls tumour cell growth Nature 441 2006 424 430
13. C.J. Marshall Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation Cell 80 1995 179 185
14. L. Chang, and Karin M. Mammalian MAP kinase signalling cascades Nature 410 2001 37 40
15. Y. Wang, Y. Zhu, and L. Zhang et al. Insulin promotes proliferation, survival, and invasion in endometrial carcinoma by activating the MEK/ERK pathway Cancer Lett 322 2012 223 231
16. Y. Mizumoto, S. Kyo, and N. Mori et al. Activation of ERK1/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis Cancer Sci 98 2007 652 658 Sci
17. A. Bellacosa, J.R. Testa, S.P. Staal, and P.N. Tsichlis A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region Science 254 1991 274 277
18. B.M. Burgering, and P.J. Coffer Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction Nature 376 1995 599 602
19. T.F. Franke, S.I. Yang, and T.O. Chan et al. The protein kinase encoded by the Akt protooncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase Cell 81 1995 727 736
20. T. Ivanova, P. Mendez, L.M. Garcia-Segura, and C. Beyer Rapid stimulation of the PI3-kinase/Akt signalling pathway in developing midbrain neurones by oestrogen J Neuroendocrinol 14 2002 73 79
21. S. Negoro, H. Oh, and E. Tone et al. Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction Circulation 103 2001 555 561
22. C. Tessier, A. Prigent-Tessier, S. Ferguson-Gottschall, Y. Gu, and G. Gibori PRL antiapoptotic effect in the rat decidua involves the PI3K/protein kinase B-mediated inhibition of caspase-3 activity Endocrinology 142 2001 4086 4094
23. S.J. Grille, A. Bellacosa, and J. Upson et al. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines Cancer Res 63 2003 2172 2178
24. M. Sun, J.E. Paciga, and R.I. Feldman et al. Phosphatidylinositol-3-OH kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K Cancer Res 61 2001 5985 5991
25. A. Vilgelm, Z. Lian, and H. Wang et al. Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice Cancer Res 66 2006 3375 3380
26. N. Mori, S. Kyo, and J. Sakaguchi et al. Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosis Cancer Sci 98 2007 1881 1888
27. A. Pant, I.I. Lee, Z. Lu, B.R. Rueda, J. Schink, and J.J. Kim Inhibition of AKT with the orally active allosteric AKT inhibitor, MK-2206, sensitizes endometrial cancer cells to progestin PLoS One 7 2012 e41593
28. D. Zhao, X.P. Li, M. Gao, C. Zhao, J.L. Wang, and L.H. Wei Stromal cell-derived factor 1alpha stimulates human endometrial carcinoma cell growth through the activation of both extracellular signal-regulated kinase 1/2 and Akt Gynecol Oncol 103 2006 932 937
29. N. Abe, J. Watanabe, S. Tsunoda, H. Kuramoto, and I. Okayasu Significance of nuclear p-Akt in endometrial carcinogenesis: rapid translocation of p-Akt into the nucleus by estrogen, possibly resulting in inhibition of apoptosis Int J Gynecol Cancer 21 2011 194 202