Single-pill combination of telmisartan and hydrochlorothiazide: Studies and pooled analyses of earlier hypertension treatment

High Blood Pressure and Cardiovascular Prevention

Volumn 21, Issue 2, 2014, Pages 119-126

  Bays, Harold ^a   Zhu, Dingliang ^b   Schumacher, Helmut ^c  

^a LOUISVILLE METABOLIC AND ATHEROSCLEROSIS RESEARCH CENTER   (United States)

^b SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Blood pressure; Early treatment; Hydrochlorothiazide; Hypertension; Single pill combination; Telmisartan

Indexed keywords

HYDROCHLOROTHIAZIDE; HYDROCHLOROTHIAZIDE PLUS TELMISARTAN; PLACEBO; TELMISARTAN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; BENZIMIDAZOLE DERIVATIVE; BENZOIC ACID DERIVATIVE; DIURETIC AGENT; DRUG COMBINATION; TELMISARTAN, HYDROCHLOROTHIAZIDE DRUG COMBINATION;

AGE; ANTIHYPERTENSIVE THERAPY; ARTICLE; ASIAN; BACKACHE; BLACK PERSON; BLOOD PRESSURE REGULATION; BODY MASS; CAUCASIAN; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL (TOPIC); DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; DISEASE DURATION; DIZZINESS; FATIGUE; GENDER; HEADACHE; HUMAN; HYPERTENSION; MONOTHERAPY; OBESITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RHINOPHARYNGITIS; SYSTOLIC BLOOD PRESSURE; UPPER RESPIRATORY TRACT INFECTION; ADULT; AGED; BLOOD PRESSURE; DRUG COMBINATION; DRUG EFFECTS; FACTUAL DATABASE; FEMALE; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; RETROSPECTIVE STUDY; TREATMENT OUTCOME;

ADULT; AGED; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANTIHYPERTENSIVE AGENTS; BENZIMIDAZOLES; BENZOATES; BLOOD PRESSURE; DATABASES, FACTUAL; DIURETICS; DRUG COMBINATIONS; FEMALE; HUMANS; HYDROCHLOROTHIAZIDE; HYPERTENSION; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84904696052     PISSN: 11209879     EISSN: 11791985     Source Type: Journal    
DOI: 10.1007/s40292-014-0041-8     Document Type: Article

References (15)

1. Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2013;31:1281-357.
2. Dahlof B, Sever PS, Poulter NR, et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet. 2005;366: 895-906. (Pubitemid 41265663)
3. Julius S, Kjeldsen SE, Weber M, et al. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet. 2004;363:2022-31. (Pubitemid 38781102)
4. Weber MA, Julius S, Kjeldsen SE, et al. Blood pressure dependent and independent effects of antihypertensive treatment on clinical events in the VALUE Trial. Lancet. 2004;363:2049-51. (Pubitemid 38781107)
5. Chobanian AV, Bakris GL, Black HR, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42: 1206-52. (Pubitemid 37553153)
6. National Institute for Health and Clinical Excellence. Hypertension: Clinical management of primary hypertension in adults. CG127 August 2011. NICE website. http://guidance.nice.org.uk/CG127.
7. Gradman AH, Basile JN, Carter BL, et al. Combination therapy in hypertension. J Clin Hypertens (Greenwich). 2011;13:146-54.
8. Mallat SG. What is a preferred angiotensin II receptor blocker-based combination therapy for blood pressure control in hypertensive patients with diabetic and non-diabetic renal impairment? Cardiovasc Diabetol. 2012;11:32.
9. Kjeldsen SE, Schmieder RE, Unger T, et al. Telmisartan and hydrochlorothiazide combination therapy for the treatment of hypertension. Curr Med Res Opin. 2010;26:879-87.
10. Schumacher H, Mancia G. The safety profile of telmisartan as monotherapy or combined with hydrochlorothiazide: a retrospective analysis of 50 studies. Blood Press Suppl. 2008;1:32-40.
11. Kjeldsen S, Mancia G, Schmieder R, et al. An update on telmisartan/ hydrochlorothiazide combinations for the management of hypertensive patients with additional cardiovascular risk factors. Expert Rev Cardiovasc Ther. 2013;11:673-82.
12. Neldam S, Dahlof B, Oigman W, et al. Early combination therapy with telmisartan plus amlodipine for rapid achievement of blood pressure goals. Int J Clin Pract. 2013;67:843-52.
13. Egan BM, Bandyopadhyay D, Shaftman SR, et al. Initial monotherapy and combination therapy and hypertension control the first year. Hypertension. 2012;59:1124-31.
14. Brown MJ, McInnes GT, Papst CC, et al. Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy for hypertension control (ACCELERATE): a randomised, parallel-group trial. Lancet. 2011;377:312-20.
15. Bangalore S, Ley L. Improving treatment adherence to antihypertensive therapy: the role of single-pill combinations. Expert Opin Pharmacother. 2012;13:345-55.