Perioperative ketorolac increases post-tonsillectomy hemorrhage in adults but not children

Laryngoscope

Volumn 124, Issue 8, 2014, Pages 1789-1793

  Chan, Dylan K ^a   Parikh, Sanjay R ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

hemorrhage; ketorolac; obstructive sleep apnea; Tonsillectomy

Indexed keywords

KETOROLAC;

ADULT; CHILD; COMPARATIVE STUDY; DRUG SAFETY; HUMAN; INFORMATION RETRIEVAL; MEDLINE; META ANALYSIS; PERIOPERATIVE PERIOD; POSTOPERATIVE COMPLICATION; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SYSTEMATIC REVIEW; TONSILLECTOMY;

HEMORRHAGE; KETOROLAC; OBSTRUCTIVE SLEEP APNEA; TONSILLECTOMY;

ADULT; AGE FACTORS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHILD; HUMANS; KETOROLAC; PAIN, POSTOPERATIVE; PERIOPERATIVE CARE; POSTOPERATIVE HEMORRHAGE; RISK ASSESSMENT; TONSILLECTOMY;

EID: 84904672631     PISSN: 0023852X     EISSN: 15314995     Source Type: Journal    
DOI: 10.1002/lary.24555     Document Type: Review

References (17)

1. Bailey R, Sinha C, Burgess LP,. Ketorolac tromethamine and hemorrhage in tonsillectomy: a prospective, randomized, double-blind study. Laryngoscope 1997; 107: 166-169.
2. Cardwell ME, Siviter G, Smith AF,. Nonsteroidal anti-inflammatory drugs and perioperative bleeding in paediatric tonsillectomy. Cochrane Database of Syst Rev 2010; 7: CD003591.
3. Baugh RF, Archer SM, Mitchell RB, et al.; American Academy of Otolaryngology-Head and Neck Surgery Foundation. Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg 2011; 144: S1-S30.
4. Judkins JH, Dray TG, Hubbell RN,. Intraoperative ketorolac and posttonsillectomy bleeding. Arch Otolaryngol Head Neck Surg 1996; 122: 937-940.
5. Kuehn BM,. FDA: no codeine after tonsillectomy for children. JAMA 2013; 309: 1100.
6. Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available at: http://www.cochrane-handbook.org. Accessed September 1, 2013.
7. Moher D, Liberati A, Tetzlaff J, Altman DG,; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009; 6: e1000097.
8. Gallagher JE, Blauth J, Fornadley JA,. Perioperative ketorolac tromethamine and postoperative hemorrhage in cases of tonsillectomy and adenoidectomy. Laryngoscope 1995; 105: 606-609.
9. Splinter WM, Rhine EJ, Roberts DW, Reid CW, Macneill HB,. Preoperative ketorolac increases bleeding after tonsillectomy in children. Can J Anaesth 1996; 43: 560-563.
10. Agrawal A, Gerson CR, Seligman I, Dsida RM,. Postoperative hemorrhage after tonsillectomy: use of ketorolac tromethamine. Otolaryngol Head Neck Surg 1999; 120: 335-339.
11. Gunter JB, Varughese AM, Harrington JF, et al. Recovery and complications after tonsillectomy in children: a comparison of ketorolac and morphine. Anesth Analg 1996; 81: 1136-1141.
12. Keidan I, Zaslansky R, Eviatar E, Segal S, Sarfaty SM,. Intraoperative ketorolac is an effective substitute for fentanyl in children undergoing outpatient adenotonsillectomy. Paediatr Anaesth 2004; 14: 318-323.
13. Romsing J, Ostergard D, Walther-Larsen S, Valentin N,. Analgesic efficacy and safety of preoperative versus postoperative ketorolac in pediatric tonsillectomy. Acta Anaesthesiol Scand 1998; 42: 770-775.
14. Rusy LM, Houck CS, Sullivan LJ, et al. A double-blind evaluation of ketorolac tromethamine versus acetaminophen in pediatric tonsillectomy: analgesia and bleeding. Anesth Analg 1995; 80: 226-229.
15. Sutter KA, Levine JD, Dibble S, Savedra M, Miaskowski C,. Analgesic efficacy and safety of single-dose intramuscular ketorolac for postoperative pain management in children following tonsillectomy. Pain 1995; 61: 145-153.
16. Pinder DK, Wilson H, Hilton MP,. Dissection versus diathermy for tonsillectomy. Cochrane Database Syst Rev 2011; 3: CD002211.
17. Sarny S, Ossimitz G, Habemann W, Stammberger H,. Hemorrhage following tonsil surgery: a multicenter prospective study. Laryngoscope 2011; 121: 2553-2560.