Comparison of intra-operative regimes of tranexamic acid administration in primary total hip replacement

Acta Orthopaedica Belgica

Volumn 80, Issue 2, 2014, Pages 228-233

  Machin, John T ^a   Batta, Vineet ^a   Soler, Juan A ^a   Sivagaganam, Kannan ^a   Kalairajah, Yegappan ^a  

^a LUTON AND DUNSTABLE HOSPITAL   (United Kingdom)

Author keywords

Blood loss; Total hip replacement; Tranexamic acid; Transfusion

Indexed keywords

ANTIFIBRINOLYTIC AGENT; TRANEXAMIC ACID;

AGED; ARTICLE; COMPARATIVE STUDY; FEMALE; HIP ARTHROPLASTY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; METHODOLOGY; MIDDLE AGED; OPERATIVE BLOOD LOSS; PEROPERATIVE CARE; RETROSPECTIVE STUDY; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; AGED; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; BLOOD LOSS, SURGICAL; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; INTRAOPERATIVE CARE; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; TRANEXAMIC ACID;

EID: 84904641657     PISSN: 00016462     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Benoni G, Fredin H, Knebel R, Nilsson P. Blood conservation with tranexamic acid in total hip arthroplasty : A randomized, double-blind study in 40 primary operations. 2001 ; 72 : 442-8
2. Benoni G, Lethagen S, Nilsson P, Fredin H. Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty. 2000 ; 71 : 250-4
3. Blood Conservation in Elective Orthopaedic Surgery. British Orthopaedic Association 2005
4. British National Formulary. Arrival at http://www.bnf.org
5. Cardone D, Klein AA. Perioperative blood conservation. 2009 ; 26 : 722-9
6. Chang RW, Pellisier JM, Hazen GB.A cost-effectiveness analysis of total hip arthroplasty for osteoarthritis of the hip. JAMA 1996 ; 20 : 858-65
7. CRASH-2 trial collaborators Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH- 2) : A randomised, placebo-controlled trial. 2010 ; 376 : 23-32
8. Finalised Patient Reported Outcome Measures (PROMs) in England - April 2009 to March 2010. Preand post-operative data : Experimental Statistics. Arrival at http://www.ic.nhs.uk/statistics-and-data-collections/hospital-care/ patient-reported-outcome-measures-proms/finalised-patient-reported-outcome- measures-proms-inengland-april-2009-to-march-2010-pre-and-post-operativedata- experimental-statistics
9. Gilbody J, Dhotar HS, Perruccio AV, Davey JR. Topical Tranexamic Acid Reduces Transfusion Rates in Total Hip and Knee Arthroplasty. J Arthroplasty 2013 ; S0883-5403 : 00649-9
10. Grosflam JM, Wright EA, Cleary PD, Katz JN. Predictors of blood loss during total hip replacement surgery. Arthritis Care Res 1995 ; 8 : 167-173
11. Helm AT, Karski MT, Parsons SJ, Sampath JS, Bale RS. A strategy for reducing blood-transfusion requirements in elective orthopaedic surgery. Audit of an algorithm for arthroplasty of the lower limb. 2003 ; 85 : 484-9
12. Hiippala S, Strid L, Wennerstrand M et al. Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty. 1995 ; 74 : 534-7
13. Irisson E, Hémon Y, Pauly V et al. Tranexamic acid reduces blood loss and financial cost in primary total hip and knee replacement surgery. Orthop Traumatol Surg Res 2012 ; 98 : 477-83
14. Ker K, Edwards P, Perel P, Shakur H, Roberts I. Effect of tranexamic acid on surgical bleeding : systematic review and cumulative meta-analysis. BMJ 2012 ; 17 ; 344 : e3054
15. Kumar A. Perioperative management of anemia: limits of blood transfusion and alternatives to it. 2009 ; 76 Suppl 4 : S112-8
16. Lemaire R. J Bone Joint Surg Br 2008 ; 90 : 1128-36
17. Malchau H, Garellick G, Eisler T, Karrholm J, Herberts P. Presidential guest address : The Swedish Hip Registry : increasing the sensitivity by patient outcome data. Clin Orthop Relat Res 2005 ; 441 : 19-29
18. Maniatis A, Hardy J, van der Linden P. Alternatives to Blood Transfusion in Transfusion Medicine, 2nd Edition, Hoboken : Wiley-Blackwell, 2011 : 65
19. Murkin JM, Falter F, Granton J, et al. High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients. Anesth Analg 2010 ; 110 : 350-353
20. NHS Blood and Transplant. Arrival at http://www. nhsbt.nhs.uk/news/2011/ newsrelease060911.html
21. Niskanen RO, Korkala OL. Tranexamic acid reduces blood loss in cemented hip arthroplasty : A randomized, double-blind study of 39 patients with osteoarthritis. 2005 ; 76 : 829-32
22. Orthoconsent.com. Arrival at http://www.orthoconsent.Com
23. Sukeik M, Alshryda S, Haddad FS, Mason JM. Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement. 2011 ; 93 : 39-46
24. SPSS. Arrival at http://www-01.ibm.com/software/ analytics/spss/
25. Trice ME, Walker RH, D'Lima DD, Morris BA, Colwell CW Jr. Blood loss and transfusion rate in noncemented and cemented/hybrid total hip arthroplasty. is there a difference ? A comparison of 25 matched pairs. 1999 ; 22 : S141-4
26. Venous thromboembolic diseases. niCE Clinical guideline Cg144 (June 2012). Arrival at http://guidance. nice.org.uk/Cg144
27. Wong J, Abrishami A, El Beheiry H et al et al. Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty : A randomized, controlled trial. 2010 ; 92 : 2503-13