Reduced Krüppel-like Factor 17 (KLF17) Expression Correlates with Poor Survival in Patients with Gastric Cancer

Archives of Medical Research

Volumn 45, Issue 5, 2014, Pages 394-399

  Peng, Jing jing ^a   Wu, Biao ^b   Xiao, Xin bo ^b   Shao, Yong sheng ^b   Feng, Yan ^b   Yin, Meng xin ^b  

^a General Hospital of the Yangtze River Shipping   (China)

^b First Hospital of Wuhan City   (China)

Author keywords

Immunohistochemistry; KLF17; Prognosis; Stomach neoplasms; Western blotting

Indexed keywords

KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 17; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER SIZE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; CYTOPLASM; DISEASE FREE SURVIVAL; DOWN REGULATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH VESSEL METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PROTEIN EXPRESSION; STOMACH ADENOCARCINOMA; STOMACH CANCER; STOMACH MUCOSA; WESTERN BLOTTING;

IMMUNOHISTOCHEMISTRY; KLF17; PROGNOSIS; STOMACH NEOPLASMS; WESTERN BLOTTING;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; STOMACH NEOPLASMS; SURVIVAL ANALYSIS; TRANSCRIPTION FACTORS; TUMOR BURDEN; TUMOR MARKERS, BIOLOGICAL;

EID: 84904600055     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2014.06.005     Document Type: Article

References (18)

1. Jemal A., Bray F., Center M.M., et al. Global cancer statistics. CA Cancer J Clin 2011, 61:69-90.
2. Sun Z., Wang Z.N., Zhu Z., et al. Evaluation of the seventh edition of American Joint Committee on Cancer TNM staging system for gastric cancer: results from a Chinese monoinstitutional study. Ann Surg Oncol 2012, 19:1918-1927.
3. McConnell B.B., Ang V.W. Mammalian Kruppel-like factors in health and diseases. Physiol Rev 2010, 90:1337-1381.
4. van Vliet J., Crofts L.A., Quinlan K.G., et al. Human KLF17 is a new member of the Sp/KLF family of transcription factors. Genomics 2006, 87:474-482.
5. Gumireddy K., Li A., Gimotty P.A., et al. KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Nat Cell Biol 2009, 11:1297-1304.
6. Iwanicki M.P., Brugge J.S. Transcriptional regulation of metastatic (Id)entity by KLF17. Genome Biol 2009, 10:244.
7. Ismail I.A., Kang H.S., Lee H.J., et al. 2-Hydroxycinnamaldehyde inhibits the epithelial-mesenchymal transition in breast cancer cells. Breast Cancer Res Treat 2013, 137:697-708.
8. Sun Z., Han Q., Zhou N., et al. MicroRNA-9 enhances migration and invasion through KLF17 in hepatocellular carcinoma. Mol Oncol 2013, 7:884-894.
9. Cai X.D., Zhou Y.B., Huang L.X., et al. Reduced expression of Kruppel-like factor 17 is related to tumor growth and poor prognosis in lung adenocarcinoma. Biochem Biophys Res Commun 2012, 418:67-73.
10. Liu F.Y., Deng Y.L., Li Y., et al. Down-regulated KLF17 expression is associated with tumor invasion and poor prognosis in hepatocellular carcinoma. Med Oncol 2013, 30:425.
11. Hyung W.J., Lee J.H., Choi S.H., et al. Prognostic impact of lymphatic and/or blood vessel invasion in patients with node-negative advanced gastric cancer. Ann Surg Oncol 2002, 9:562-567.
12. rd English ed. Gastric Cancer 2011, 14:101-112.
13. Washington K. 7th ed. of the AJCC Cancer Staging Manual: Stomach. Ann Surg Oncol 2010, 17:3077-3079.
14. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965, 64:31-49.
15. Dicken B.J., Graham K., Hamilton S.M., et al. Lymphovascular invasion is associated with poor survival in gastric cancer: an application of gene-expression and tissue array techniques. Ann Surg 2006, 243:64-73.
16. del Casar J.M., Corte M.D., Alvarez A., et al. Lymphatic and/or blood vessel invasion in gastric cancer: relationship with clinicopathological parameters, biological factors and prognostic significance. J Cancer Res Clin Oncol 2008, 134:153-161.
17. Kim J.H., Park S.S., Park S.H., et al. Clinical significance of immunohistochemically-identified lymphatic and/or blood vessel tumor invasion in gastric cancer. J Surg Res 2010, 162:177-183.
18. Selcukbiricik F., Buyukunal E., Tural D., et al. Clinicopathological features and outcomes of patients with gastric cancer: a single-center experience. World J Gastroenterol 2013, 19:2154-2161.