QnrS1 structure-activity relationships

Journal of Antimicrobial Chemotherapy

Volumn 69, Issue 8, 2014, Pages 2102-2109

  Tavío, María M ^a,b   Jacoby, George A ^c   Hooper, David C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^c LAHEY HOSPITAL AND MEDICAL CENTER   (United States)

Author keywords

Pentapeptide repeat proteins; QnrS; Quinolone resistance

Indexed keywords

ALANINE; ARGININE; CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); MEMBRANE PROTEIN; QNRS1 PROTEIN; QUINOLONE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; DNA SUPERCOILING; ESCHERICHIA COLI PROTEIN; ISOPROPYL THIOGALACTOSIDE; QNR PROTEIN, E COLI;

AFFINITY CHROMATOGRAPHY; ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; DNA SUPERCOILING; ESCHERICHIA COLI; GENE EXPRESSION; GENE MUTATION; IC 50; MINIMUM INHIBITORY CONCENTRATION; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; WILD TYPE; ANTIBIOTIC RESISTANCE; DRUG EFFECTS; GENETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; MUTATION; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; CIPROFLOXACIN; DNA GYRASE; DNA, SUPERHELICAL; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; ISOPROPYL THIOGALACTOSIDE; MICROBIAL SENSITIVITY TESTS; MUTATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84904555419     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dku102     Document Type: Article

References (39)

1. Martínez-Martínez L, Pascual A, Jacoby GA. Quinolone resistance from a transferable plasmid. Lancet 1998; 351: 797-9.
2. Strahilevitz J, Jacoby GA, Hooper DC et al. Plasmid-mediated quinolone resistance: a multifaceted threat. Clin Microbiol Rev 2009; 22: 664-89.
3. Jacoby GA, Hooper DC. Phylogenetic analysis of chromosomally determined qnr and related proteins. Antimicrob Agents Chemother 2013; 57: 1930-4.
4. Jacoby GA, Walsh KE, Mills DM et al. qnrB, another plasmid-mediated gene for quinolone resistance. Antimicrob Agents Chemother 2006; 50: 1178-82.
5. Cozzarelli NR. DNA topoisomerases. Cell 1980; 22: 327-8.
6. Deweese JE, Osheroff N. The use of divalent metal ions by type II topoisomerases. Metallomics 2010; 2: 450-9.
7. Kampranis SC, Maxwell A. The DNA gyrase-quinolone complex. ATP hydrolysis and the mechanism of DNA cleavage. J Biol Chem 1998; 273: 22615-26.
8. Tran JH, Jacoby GA. Mechanism of plasmid-mediated quinolone resistance. Proc Natl Acad Sci USA 2002; 99: 5638-42.
9. Tran JH, Jacoby GA, Hooper DC. Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase. Antimicrob Agents Chemother 2005; 49: 118-25.
10. Tran JH, Jacoby GA, Hooper DC. Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coli topoisomerase IV. Antimicrob Agents Chemother 2005; 49: 3050-2.
11. Vetting MW, Hegde SS, Fajardo JE et al. The pentapeptide repeat proteins. Biochemistry 2006; 45: 1-10.
12. Buchko GW, Ni S, Robinson H et al. Characterization of two potentially universal turn motifs that shape the repeated five-residues fold-crystal structure of a lumenal pentapeptide repeat protein from Cyanothece 51142. Protein Sci 2006; 15: 2579-95.
13. Mérens A, Matrat S, Aubry A et al. The pentapeptide repeat proteins MfpAMt, and QnrB4 exhibit opposite effects on DNA gyrase catalytic reactions and on the ternary gyrase-DNA-quinolone complex. J Bacteriol 2009; 191: 1587-94.
14. Hegde SS, Vetting MW, Roderick SL et al. A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA. Science 2005; 308: 1480-3.
15. Hegde SS, Vetting MW, Mitchenall LA et al. Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor. Antimicrob Agents Chemother 2011; 55: 110-7.
16. VettingMW, Hegde SS, Zhang Yet al. Pentapeptide-repeat proteins that act as topoisomerase poison resistance factors have a common dimer interface. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011; 67: 296-302.
17. Vetting MW, Hegde SS, Wang M et al. Structure of QnrB1, a plasmid-mediated fluoroquinolone resistance factor. J Biol Chem 2011; 286: 25265-73.
18. Xiong X, Bromley EHC, Oelschlaeger P et al. Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a Gram-negative bacterium. Nucleic Acids Res 2011; 39: 3917-27.
19. Park KS, Lee JH, Jeong DU et al. Determination of pentapeptide repeat units in Qnr proteins by the structure-based alignment approach. Antimicrob Agents Chemother 2011; 55: 4475-8.
20. Gay K, Robicsek A, Strahilevitz J et al. Plasmid-mediated quinolone resistance in non-Typhi serotypes of Salmonella enterica. Clin Infect Dis 2006; 43: 297-304.
21. Morrison KL, Weiss GA. Combinatorial alanine-scanning. Curr Opin Chem Biol 2001; 5: 302-7.
22. Jeong H, Barbe V, Lee CH et al. Genome sequences of Escherichia coli B strains REL606 and BL21(DE3). J Mol Biol 2009; 394: 644-52.
23. Novagen. pET System Manual, 11th edn. http://kirschner.med.harvard. edu/files/protocols/Novagen_petsystem.pdf (2 January 2014, date last accessed).
24. Clinical and Laboratory Standards Institute. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically-Seventh Edition: Approved standard M7-A7. CLSI, Wayne, PA, USA, 2006.
25. Tsumoto K, Umetsu M, Kumagai I et al. Role of arginine in protein refolding, solubilization, and purification. Biotechnol Prog 2004; 20: 1301-8.
26. Masecar BL, Celesk RA, Robillard NJ. Analysis of acquired ciprofloxacin resistance in a clinical strain of Pseudomonas aeruginosa. Antimicrob Agents Chemother 1990; 34: 281-6.
27. Majumdar T, Das B, Bhadra RK et al. Complete nucleotide sequence of a quinolone resistance gene (qnrS2) carrying plasmid of Aeromonas hydrophila isolated from fish. Plasmid 2011; 66: 79-84.
28. Yue L, Jiang H-X, Liao X-P et al. Prevalence of plasmid-mediated quinolone resistance qnr genes in poultry and swine clinical isolates of Escherichia coli. Vet Microbiol 2008; 132: 414-20.
29. Han JE, Kim JH, Cheresca CH Jr et al. First description of the qnrS-like (qnrS5) gene and analysis of quinolone resistance-determining regions in motile Aeromonas spp. from diseased fish and water. Res Microbiol 2012; 163: 73-9.
30. Xia R, Guo X, Zhang Y et al. qnrVC-like gene located in a novel complex class 1 integron harboring the ISCR1 element in an Aeromonas punctata strain from an aquatic environment in Shandong Province, China. Antimicrob Agents Chemother 2010; 54: 3471-4.
31. Chen X, Zhang W, Pan W et al. Prevalence of qnr, aac(6')- Ib-cr, qepA, and oqxAB in Escherichia coli isolates from humans, animals, and the environment. Antimicrob Agents Chemother 2012; 56: 3423-7.
32. Cambau E, Lascols C, Sougakoff W et al. Occurrence of qnrA-positive clinical isolates in French teaching hospitals during 2002-2005. Clin Microbiol Infect 2006; 12: 1013-20.
33. Wang M, Guo Q, Xu X et al. New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. Antimicrob Agents Chemother 2009; 53: 1892-7.
34. Jacoby G, Cattoir V, Hooper D et al. qnr gene nomenclature. Antimicrob Agents Chemother 2008; 52: 2297-9.
35. Cavaco LM, Hasman H, Xia S et al. qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. Antimicrob Agents Chemother 2009; 53: 603-8.
36. qnr Numbering and Sequence. http://www.lahey.org/qnrstudies/ (7 August 2013, date last accessed).
37. Yamaguchi Y, Tomoyasu T, Takaya A et al. Effects of disruption of heat shock genes on susceptibility of Escherichia coli to fluoroquinolones. BCM Microbiol 2003; 3: 16.
38. Okumura R, Liao CH, Gavin M et al. Quinolone induction of qnrVS1 in Vibrio splendidus and plasmid-carried qnrS1 in Escherichia coli, a mechanism independent of the SOS system. Antimicrob Agents Chemother 2011; 55: 5942-5.
39. Rodríguez-Martínez JM, Briales A, Velasco C et al. Mutational analysis of quinolone resistance in the plasmid-encoded pentapeptide repeat proteins QnrA, QnrB and QnrS. J Antimicrob Chemother 2009; 63: 1128-34.