Prostaglandin pathway gene expression in human placenta, amnion and choriodecidua is differentially affected by preterm and term labour and by uterine inflammation

BMC Pregnancy and Childbirth

Volumn 14, Issue 1, 2014, Pages

  Phillips, Robert J ^a   Fortier, Michel A ^b   López Bernal, Andrés ^a,c  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b LAVAL UNIVERSITY   (Canada)

^c ST MICHAEL'S HOSPITAL   (United Kingdom)

Author keywords

Inflammation; Parturition; Pregnancy; Uterus

Indexed keywords

15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ABCC4 PROTEIN, HUMAN; AKR1B1 PROTEIN, HUMAN; AKR1C3 PROTEIN, HUMAN; ALCOHOL DEHYDROGENASE; ALDEHYDE REDUCTASE; CALGRANULIN A; CBR1 PROTEIN, HUMAN; CYCLOOXYGENASE 2; CYTOCHROME P450; INTERLEUKIN 1; ISOMERASE; MULTIDRUG RESISTANCE PROTEIN; ORGANIC ANION TRANSPORTER; PROSTAGLANDIN; PROSTAGLANDIN E SYNTHASE; PTGIS PROTEIN, HUMAN; PTGS2 PROTEIN, HUMAN; SLCO2A1 PROTEIN, HUMAN; TLR2 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 2;

ADULT; AMNION; CHEMISTRY; CHORIOAMNIONITIS; CHORION; DECIDUA; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENETICS; GESTATIONAL AGE; HUMAN; LABOR; METABOLISM; PLACENTA; PREGNANCY; PREMATURE LABOR; SIGNAL TRANSDUCTION; UPREGULATION; YOUNG ADULT;

3-HYDROXYSTEROID DEHYDROGENASES; ADULT; ALCOHOL OXIDOREDUCTASES; ALDEHYDE REDUCTASE; AMNION; CALGRANULIN A; CHORIOAMNIONITIS; CHORION; CYCLOOXYGENASE 2; CYTOCHROME P-450 ENZYME SYSTEM; DECIDUA; DOWN-REGULATION; FEMALE; GENE EXPRESSION; GESTATIONAL AGE; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; INTERLEUKIN-1; INTRAMOLECULAR OXIDOREDUCTASES; LABOR, OBSTETRIC; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OBSTETRIC LABOR, PREMATURE; ORGANIC ANION TRANSPORTERS; PLACENTA; PREGNANCY; PROSTAGLANDINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; UP-REGULATION; YOUNG ADULT;

EID: 84904519766     PISSN: None     EISSN: 14712393     Source Type: Journal    
DOI: 10.1186/1471-2393-14-241     Document Type: Article

References (56)

1. Challis JR, Sloboda DM, Alfaidy N, Lye SJ, Gibb W, Patel FA, Whittle WL, Newnham JP. Prostaglandins and mechanisms of preterm birth. Reproduction 2002, 124:1-17. 10.1530/rep.0.1240001, 12090913.
2. Fortier MA, Krishnaswamy K, Danyod G, Boucher-Kovalik S, Chapdelaine JA. A postgenomic integrated view of prostaglandins in reproduction: implications for other body systems. J Phys Pharm 2008, 59(Suppl 1):65-89.
3. Christiaens I, Zaragoza DB, Guilbert L, Robertson SA, Mitchell BF, Olson DM. Inflammatory processes in preterm and term parturition. J Reprod Immunol 2008, 79:50-57. 10.1016/j.jri.2008.04.002, 18550178.
4. López Bernal A, Hansell DJ, Khong TY, Keeling JW, Turnbull AC. Prostaglandin E production by the fetal membranes in unexplained preterm labour and preterm labour associated with chorioamnionitis. Br J Obstet Gynaecol 1989, 96:1133-1139. 10.1111/j.1471-0528.1989.tb03187.x, 2590651.
5. López Bernal A, Hansell DJ, Khong TY, Keeling JW, Turnbull AC. Placental leukotriene B4 release in early pregnancy and in term and preterm labour. Early Hum Dev 1990, 23:93-99. 10.1016/0378-3782(90)90132-3, 2175261.
6. López Bernal A, Hansell DJ, Cañete Soler R, Keeling JW, Turnbull AC. Prostaglandins, chorioamnionitis and preterm labour. Br J Obstet Gynaecol 1987, 94:1156-1158. 10.1111/j.1471-0528.1987.tb02315.x, 2827724.
7. Mueller-Heubach E, Rubinstein DN, Schwarz SS. Histologic chorioamnionitis and preterm delivery in different patient populations. Obstet Gynecol 1990, 75:622-626.
8. Hillier SL, Witkin SS, Krohn MA, Watts DH, Kiviat NB, Eschenbach DA. The relationship of amniotic fluid cytokines and preterm delivery, amniotic fluid infection, histologic chorioamnionitis, and chorioamnion infection. Obstet Gynecol 1993, 81:941-948.
9. Opsjøn SL, Wathen NC, Tingulstad S, Wiedswang G, Sundan A, Waage A, Austgulen R. Tumor necrosis factor, interleukin-1 and interleukin-6 in normal human pregnancy. Am J Obstet Gynecol 1993, 169:397-404. 10.1016/0002-9378(93)90096-2, 8362955.
10. Steinborn A, Günes H, Röddiger S, Halberstadt E. Elevated placental cytokine release, a process associated with preterm labor in the absence of intrauterine infection. Obstet Gynecol 1996, 88:534-539. 10.1016/0029-7844(96)00224-4, 8841213.
11. Leitich H, Bodner-Adler B, Brunbauer M, Kaider A, Egarter C, Husslein P. Bacterial vaginosis as a risk factor for preterm delivery: a meta-analysis. Am J Obstet Gynecol 2003, 189:139-147. 10.1067/mob.2003.339, 12861153.
12. Shim SS, Romero R, Hong JS, Park CW, Jun JK, Kim BI, Yoon BH. Clinical significance of intra-amniotic inflammation in patients with preterm premature rupture of membranes. Am J Obstet Gynecol 2004, 191:1339-1345. 10.1016/j.ajog.2004.06.085, 15507963.
13. Phillips RJ, Al-Zamil H, Hunt LP, Fortier MA, López Bernal A. Genes for prostaglandin synthesis, transport and inactivation are differentially expressed in human uterine tissues, and the prostaglandin F synthase AKR1B1 is induced in myometrial cells by inflammatory cytokines. Mol Hum Reprod 2011, 17:1-13. 10.1093/molehr/gaq057, 20595240.
14. Xu Y, Knipp GT, Cook TJ. Expression of cyclooxygenase isoforms in developing rat placenta, human term placenta, and BeWo human trophoblast model. Mol Pharm 2005, 2:481-490. 10.1021/mp0500519, 16323955.
15. Wetzka B, Nüsing R, Charnock-Jones DS, Schäfer W, Zahradnik HP, Smith SK. Cyclooxygenase-1 and -2 in human placenta and placental bed after normal and pre-eclamptic pregnancies. Hum Reprod 1997, 12:2313-2320. 10.1093/humrep/12.10.2313, 9402302.
16. Meadows JW, Pitzer B, Brockman DE, Myatt L. Differential localization of prostaglandin E synthase isoforms in human placental cell types. Placenta 2004, 25:259-265. 10.1016/j.placenta.2003.09.004, 15028417.
17. Dunn-Albanese LR, Ackerman WE, Xie Y, Iams JD, Kniss DA. Reciprocal expression of peroxisome proliferator-activated receptor-gamma and cyclooxygenase-2 in human term parturition. Am J Obstet Gynecol 2004, 190:809-816. 10.1016/j.ajog.2003.09.052, 15042019.
18. Cheung PY, Walton JC, Tai HH, Riley SC, Challis JR. Immunocytochemical distribution and localization of 15-hydroxyprostaglandin dehydrogenase in human fetal membranes, decidua and placenta. Am J Obstet Gynecol 1990, 163:1445-1449. 10.1016/0002-9378(90)90603-5, 2240085.
19. Breuiller-Fouché M, Leroy MJ, Dubois O, Reinaud P, Chissey A, Qi H, Germain G, Fortier MA, Charpigny G. Differential expression of the enzymatic system controlling synthesis, metabolism, and transport of PGF2 alpha in human fetal membranes. Biol Reprod 2010, 83:155-162. 10.1095/biolreprod.109.080390, 20357271.
20. Gibb W, Sun M. Localization of prostaglandin H synthase type 2 protein and mRNA in term human fetal membranes and decidua. J Endocrinol 1996, 150:497-503. 10.1677/joe.0.1500497, 8882169.
21. Alfaidy N, Sun M, Challis JR, Gibb W. Expression of membrane prostaglandin E synthase in human placenta and fetal membranes and effect of labor. Endocrine 2003, 20:219-225. 10.1385/ENDO:20:3:219, 12721500.
22. Premyslova M, Li W, Alfaidy N, Bocking AD, Campbell K, Gibb W, Challis JR. Differential expression and regulation of microsomal prostaglandin E(2) synthase in human fetal membranes and placenta with infection and in cultured trophoblast cells. J Clin Endocrinol Metab 2003, 88:6040-6047. 10.1210/jc.2003-030618, 14671209.
23. Meadows JW, Eis AL, Brockman DE, Myatt L. Expression and localization of prostaglandin E synthase isoforms in human fetal membranes in term and preterm labor. J Clin Endocrinol Metab 2003, 88:433-439. 10.1210/jc.2002-021061, 12519887.
24. Sangha RK, Walton JC, Ensor CM, Tai HH, Challis JR. Immunohistochemical localization, messenger ribonucleic acid abundance, and activity of 15-hydroxyprostaglandin dehydrogenase in placenta and fetal membranes during term and preterm labor. J Clin Endocrinol Metab 1994, 78:982-989.
25. Hirsch E, Goldstein M, Filipovich Y, Wang H. Placental expression of enzymes regulating prostaglandin synthesis and degradation. Am J Obstet Gynecol 2005, 192:1836-1842. 10.1016/j.ajog.2004.12.070, 15970823.
26. Mijovic JE, Zakar T, Nairn TK, Olson DM. Prostaglandin endoperoxide H synthase (PGHS) activity and PGHS-1 and -2 messenger ribonucleic acid abundance in human chorion throughout gestation and with preterm labor. J Clin Endocrinol Metab 1998, 83:1358-1367.
27. Mijovic JE, Zakar T, Angelova J, Olson DM. Prostaglandin endoperoxide H synthase mRNA expression in the human amnion and decidua during pregnancy and in the amnion at preterm labour. Mol Hum Reprod 1999, 5:182-187. 10.1093/molehr/5.2.182, 10065875.
28. Slater DM, Dennes WJ, Campa JS, Poston L, Bennett PR. Expression of cyclo-oxygenase types-1 and -2 in human myometrium throughout pregnancy. Mol Hum Reprod 1999, 5:880-884. 10.1093/molehr/5.9.880, 10460228.
29. Johnson RF, Mitchell CM, Giles WB, Bisits A, Zakar T. Mechanisms regulating prostaglandin H2 synthase-2 mRNA level in the amnion and chorion during pregnancy. J Endocrinol 2006, 188:603-610. 10.1677/joe.1.06488, 16522739.
30. Freed KA, Aitken MA, Brennecke SP, Rice GE. Prostaglandin G/H synthase-1 messenger RNA relative abundance in human amnion, choriodecidua and placenta before, during and after spontaneous-onset labour at term. Gynecol Obstet Invest 1995, 39:73-78. 10.1159/000292383, 7737586.
31. Hirst JJ, Teixeira FJ, Zakar T, Olson DM. Prostaglandin endoperoxide-H synthase-1 and -2 messenger ribonucleic acid levels in human amnion with spontaneous labor onset. J Clin Endocrinol Metab 1995, 80:517-523.
32. Slater DM, Berger LC, Newton R, Moore GE, Bennett PR. Expression of cyclooxygenase types 1 and 2 in human fetal membranes at term. Am J Obstet Gynecol 1995, 172:77-82. 10.1016/0002-9378(95)90087-X, 7531399.
33. Slater D, Allport V, Bennett P. Changes in the expression of the type-2 but not the type-1 cyclo-oxygenase enzyme in chorion-decidua with the onset of labour. Br J Obstet Gynaecol 1998, 105:745-748. 10.1111/j.1471-0528.1998.tb10205.x, 9692415.
34. Zakar T, Olson DM, Teixeira FJ, Hirst JJ. Regulation of prostaglandin endoperoxide H2 synthase in term human gestational tissues. Acta Physiol Hung 1996, 84:109-118.
35. Mijovic JE, Zakar T, Nairn TK, Olso DM. Prostaglandin-endoperoxide H synthase-2 expression and activity increases with term labor in human chorion. Am J Physiol 1997, 272:E832-840.
36. Hirst JJ, Mijovic JE, Zakar T, Olson DM. Prostaglandin endoperoxide H synthase-1 and -2 mRNA levels and enzyme activity in human decidua at term labor. J Soc Gynecol Investig 1998, 5:13-20. 10.1016/S1071-5576(97)00101-9, 9501293.
37. Makino S, Zaragoza DB, Mitchell BF, Yonemoto H, Olson DM. Decidual activation: abundance and localization of prostaglandin F2alpha receptor (FP) mRNA and protein and uterine activation proteins in human decidua at preterm birth and term birth. Placenta 2007, 28:557-565. 10.1016/j.placenta.2006.06.010, 16911823.
38. Freed KA, Moses EK, Brennecke SP, Rice GE. Differential expression of type II, IV and cytosolic PLA2 messenger RNA in human intrauterine tissues at term. Mol Hum Reprod 1997, 3:493-499. 10.1093/molehr/3.6.493, 9239738.
39. Helliwell RJ, Keelan JA, Marvin KW, Adams L, Chang MC, Anand A, Sato TA, O'Carroll S, Chaiworapongsa T, Romero RJ, Mitchell MD. Gestational age-dependent up-regulation of prostaglandin D synthase (PGDS) and production of PGDS-derived antiinflammatory prostaglandins in human placenta. J Clin Endocrinol Metab 2006, 91:597-606. 10.1210/jc.2005-1982, 16291703.
40. van Meir CA, Matthews SG, Keirse MJ, Ramirez MM, Bocking A, Challis JR. 15-hydroxyprostaglandin dehydrogenase: implications in preterm labor with and without ascending infection. J Clin Endocrinal Metab 1997, 82:969-976.
41. Schoof E, Girstl M, Frobenius W, Kirschbaum M, Repp R, Knerr I, Rascher W, Dötsch J. Course of placental 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase mRNA expression during human gestation. Eur J Endocrinol 2001, 145:187-192. 10.1530/eje.0.1450187, 11454515.
42. Pomini F, Patel FA, Mancuso S, Challis JR. Activity and expression of 15-hydroxyprostaglandin dehydrogenase in cultured chorionic trophoblast and villous trophoblast cells and in chorionic explants at term with and without spontaneous labor. Am J Obstet Gynecol 2000, 182:221-226. 10.1016/S0002-9378(00)70516-3, 10649182.
43. Myatt L, Sun K. Role of fetal membranes in signaling of fetal maturation and parturition. Int J Dev Biol 2010, 54:545-553. 10.1387/ijdb.082771lm, 19924634.
44. López Bernal A, Newman GE, Phizackerley PJR, Turnbull AC. Surfactant stimulates prostaglandin E production in human amnion. Br J Obstet Gynaecol 1988, 95:1013-1017. 10.1111/j.1471-0528.1988.tb06506.x, 3191038.
45. Mitchell MD, Keirse MJ, Brunt JD, Anderson AB, Turnbull AC. Concentrations of the prostacyclin metabolite, 6-keto-prostaglandin F1 alpha, in amniotic fluid during late pregnancy and labour. Br J Obstet Gynaecol 1979, 86:350-353. 10.1111/j.1471-0528.1979.tb10609.x, 380629.
46. Lee SE, Romero R, Park IS, Seong HS, Park CW, Yoon BH. Amniotic fluid prostaglandin concentrations increase before the onset of spontaneous labor at term. J Matern Fetal Neonatal Med 2008, 21:89-94. 10.1080/14767050701830514, 18240075.
47. Keirse MJ, Turnbull AC. Metabolism of prostaglandins within the pregnant uterus. Br J Obstet Gynaecol 1975, 82:887-893. 10.1111/j.1471-0528.1975.tb00593.x, 1191603.
48. Nomura T, Lu R, Pucci ML, Schuster VL. The two-step model of prostaglandin signal termination: in vitro reconstitution with the prostaglandin transporter and prostaglandin 15 dehydrogenase. Mol Pharmacol 2004, 65:973-978. 10.1124/mol.65.4.973, 15044627.
49. Sorokin Y, Hallak M, Klein O, Kalderon I, Abramovici H. Effects of induction of labor with prostaglandin E2 on fetal breathing and body movements: controlled, randomized, double-blind study. Obstet Gynecol 1992, 80:788-791.
50. Keski-Nisula L, Aalto ML, Katila ML, Kirkinen P. Intrauterine inflammation at term: a histopathologic study. Hum Pathol 2000, 31:841-846. 10.1053/hupa.2000.8449, 10923922.
51. Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med 2000, 342:1500-1507. 10.1056/NEJM200005183422007, 10816189.
52. Romero R, Espinoza J, Kusanovic JP, Gotsch F, Hassan S, Erez O, Chaiworapongsa T, Mazor M. The preterm parturition syndrome. Br J Obstet Gynaecol 2006, 113(Suppl 3):17-42.
53. Romero R, Mazaki-Tovi S, Vaisbuch E, Kusanovic JP, Chaiworapongsa T, Gomez R, Nien JK, Yoon BH, Mazor M, Luo J, Banks D, Ryals J, Beecher C. Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery. J Matern Fetal Neonatal Med 2010, 23:1344-1359. 10.3109/14767058.2010.482618, 3440243, 20504069.
54. Pont JN, McArdle CA, López Bernal A. Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells. Mol Endocrinol 2012, 26:1743-1756. 10.1210/me.2012-1057, 3507519, 22902539.
55. Fuentes A, Spaziani EP, O'Brien WF. The expression of cyclooxygenase-2 (COX-2) in amnion and decidua following spontaneous labor. Prostaglandins 1996, 52:261-267.
56. Romero R, Parvizi ST, Oyarzun E, Mazor M, Wu YK, Avila C, Athanassiadis AP, Mitchell MD. Amniotic fluid interleukin-1 in spontaneous labor at term. J Reprod Med 1990, 35:235-238.