Detection of anti-p155/140, anti-p140, and antiendothelial cells autoantibodies in patients with juvenile dermatomyositis

Journal of Microbiology, Immunology and Infection

Volumn 49, Issue 2, 2016, Pages 264-270

  Yu, Hsin Hui ^a   Chang, Hsien Mei ^b   Chiu, Chiao Juno ^c   Yang, Yao Hsu ^a   Lee, Jyh Hong ^a   Wang, Li Chieh ^a   Lin, Yu Tsan ^a   Chiang, Bor Luen ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Anti endothelial cell antibodies; Anti p140; Anti p155 140; Autoantibodies; Juvenile dermatomyositis (JDM)

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN;

ADOLESCENT; BLOOD; CHILD; DERMATOMYOSITIS; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOBLOTTING; IMMUNOLOGY; INFANT; MALE; PATHOLOGY; PRESCHOOL CHILD; YOUNG ADULT;

ADOLESCENT; AUTOANTIBODIES; AUTOANTIGENS; CHILD; CHILD, PRESCHOOL; DERMATOMYOSITIS; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOBLOTTING; INFANT; MALE; YOUNG ADULT;

EID: 84904518378     PISSN: 16841182     EISSN: 19959133     Source Type: Journal    
DOI: 10.1016/j.jmii.2014.05.012     Document Type: Article

References (32)

1. Feldman B.M., Rider L.G., Reed A.M., Pachman L.M. Juvenile dermatomyositis and other idiopathic inflammatory myopathies of childhood. Lancet 2008, 371:2201-2212.
2. Hill C.L., Zhang Y., Sigurgeirsson B., Pukkala E., Mellemkjaer L., Airio A., et al. Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet 2001, 357:96-100.
3. Rider L.G. The heterogeneity of juvenile myositis. Autoimmun Rev 2007, 6:241-247.
4. Targoff I.N., Mamyrova G., Trieu E.P., Perurena O., Koneru B., O'Hanlon T.P., et al. A novel autoantibody to a 155-kd protein is associated with dermatomyositis. Arthritis Rheum 2006, 54:3682-3689.
5. Kaji K., Fujimoto M., Hasegawa M., Kondo M., Saito Y., Komura K., et al. Identification of a novel autoantibody reactive with 155 and 140 kDa nuclear proteins in patients with dermatomyositis: an association with malignancy. Rheumatology (Oxford) 2007, 46:25-28.
6. Fujimoto M., Hamaguchi Y., Kaji K., Matsushita T., Ichimura Y., Kodera M., et al. Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins. Arthritis Rheum 2012, 64:513-522.
7. Betteridge Z.E., Gunawardena H., McHugh N.J. Novel autoantibodies and clinical phenotypes in adult and juvenile myositis. Arthritis Res Ther 2011, 13:209.
8. Gunawardena H., Wedderburn L.R., North J., Betteridge Z., Dunphy J., Chinoy H., et al. Clinical associations of autoantibodies to a p155/140 kDa doublet protein in juvenile dermatomyositis. Rheumatology (Oxford) 2008, 47:324-328.
9. Ichimura Y., Matsushita T., Hamaguchi Y., Kaji K., Hasegawa M., Tanino Y., et al. Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy. Ann Rheum Dis 2012, 71:710-713.
10. Gunawardena H., Wedderburn L.R., Chinoy H., Betteridge Z.E., North J., Ollier W.E., et al. Autoantibodies to a 140-kd protein in juvenile dermatomyositis are associated with calcinosis. Arthritis Rheum 2009, 60:1807-1814.
11. Espada G., Maldonado Cocco J.A., Fertig N., Oddis C.V. Clinical and serologic characterization of an Argentine pediatric myositis cohort: identification of a novel autoantibody (anti-MJ) to a 142-kDa protein. J Rheumatol 2009, 36:2547-2551.
12. Kaneko K., Savage C.O., Pottinger B.E., Shah V., Pearson J.D., Dillon M.J. Antiendothelial cell antibodies can be cytotoxic to endothelial cells without cytokine pre-stimulation and correlate with ELISA antibody measurement in Kawasaki disease. Clin Exp Immunol 1994, 98:264-269.
13. Savage C.O., Pottinger B.E., Gaskin G., Lockwood C.M., Pusey C.D., Pearson J.D. Vascular damage in Wegener's granulomatosis and microscopic polyarteritis: presence of anti-endothelial cell antibodies and their relation to anti-neutrophil cytoplasm antibodies. Clin Exp Immunol 1991, 85:14-19.
14. Tripathy N.K., Upadhyaya S., Sinha N., Nityanand S. Complement and cell mediated cytotoxicity by antiendothelial cell antibodies in Takayasu's arteritis. J Rheumatol 2001, 28:805-808.
15. Servettaz A., Guilpain P., Tamas N., Kaveri S.V., Camoin L., Mouthon L. Natural anti-endothelial cell antibodies. Autoimmunity reviews 2008, 7:426-430.
16. Yang Y.H., Huang Y.H., Lin Y.L., Wang L.C., Chuang Y.H., Yu H.H., et al. Circulating IgA from acute stage of childhood Henoch-Schonlein purpura can enhance endothelial interleukin (IL)-8 production through MEK/ERK signalling pathway. Clin Exp Immunol 2006, 144:247-253.
17. Domiciano D.S., Carvalho J.F., Shoenfeld Y. Pathogenic role of anti-endothelial cell antibodies in autoimmune rheumatic diseases. Lupus 2009, 18:1233-1238.
18. Yang Y.H., Chuang Y.H., Wang L.C., Huang H.Y., Gershwin M.E., Chiang B.L. The immunobiology of Henoch-Schonlein purpura. Autoimmun Rev 2008, 7:179-184.
19. Bohan A., Peter J.B. Polymyositis and dermatomyositis (first of two parts). N Engl J Med 1975, 292:344-347.
20. Jaffe E.A., Nachman R.L., Becker C.G., Minick C.R. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 1973, 52:2745-2756.
21. Faul F., Erdfelder E., Buchner A., Lang A.G. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009, 41:1149-1160.
22. Hoshino K., Muro Y., Sugiura K., Tomita Y., Nakashima R., Mimori T. Anti-MDA5 and anti-TIF1-gamma antibodies have clinical significance for patients with dermatomyositis. Rheumatology (Oxford) 2010, 49:1726-1733.
23. Trallero-Araguas E., Rodrigo-Pendas J.A., Selva-O'Callaghan A., Martinez-Gomez X., Bosch X., Labrador-Horrillo M., et al. Usefulness of anti-p155 autoantibody for diagnosing cancer-associated dermatomyositis: a systematic review and meta-analysis. Arthritis Rheum 2012, 64:523-532.
24. Dupont S., Mamidi A., Cordenonsi M., Montagner M., Zacchigna L., Adorno M., et al. FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell 2009, 136:123-135.
25. Kang E.H., Nakashima R., Mimori T., Kim J., Lee Y.J., Lee E.B., et al. Myositis autoantibodies in Korean patients with inflammatory myositis: anti-140-kDa polypeptide antibody is primarily associated with rapidly progressive interstitial lung disease independent of clinically amyopathic dermatomyositis. BMC Musculoskelet Disord 2010, 11:223.
26. Kimura Y., Sakai F., Nakano O., Kisaki O., Sugimoto H., Sawamura T., et al. The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains. J Biol Chem 2002, 277:20611-20617.
27. Rosendorff A., Sakakibara S., Lu S., Kieff E., Xuan Y., DiBacco A., et al. NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. Proc Natl Acad Sci U S A 2006, 103:5308-5313.
28. Wedderburn L.R., Rider L.G. Juvenile dermatomyositis: new developments in pathogenesis, assessment and treatment. Best Pract Res Clin Rheumatol 2009, 23:665-678.
29. Nagaraju K., Rider L.G., Fan C., Chen Y.W., Mitsak M., Rawat R., et al. Endothelial cell activation and neovascularization are prominent in dermatomyositis. J Autoimmune Dis 2006, 3:2.
30. Belizna C., Duijvestijn A., Hamidou M., Tervaert J.W. Antiendothelial cell antibodies in vasculitis and connective tissue disease. Ann Rheum Dis 2006, 65:1545-1550.
31. Trallero-Araguas E., Labrador-Horrillo M., Selva-O'Callaghan A., Martinez M.A., Martinez-Gomez X., Palou E., et al. Cancer-associated myositis and anti-p155 autoantibody in a series of 85 patients with idiopathic inflammatory myopathy. Medicine 2010, 89:47-52.
32. Labrador-Horrillo M., Martinez M.A., Selva-O'Callaghan A., Trallero-Araguas E., Balada E., Vilardell-Tarres M., et al. Anti-TIF1gamma antibodies (anti-p155) in adult patients with dermatomyositis: comparison of different diagnostic assays. Ann Rheum Dis 2012, 71:993-996.