A novel autoantibody to a 155-kd protein is associated with dermatomyositis

Arthritis and Rheumatism

Volumn 54, Issue 11, 2006, Pages 3682-3689

  Targoff, Ira N ^a,c   Mamyrova, Gulnara ^b   Trieu, Edward P ^c   Perurena, Osvaldo ^d   Koneru, Bhanu ^b   O'Hanlon, Terrance P ^b   Miller, Frederick W ^b   Rider, Lisa G ^b  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^d TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSFER RNA LIGASE; ANTIGEN; AUTOANTIBODY; IDIOTYPIC ANTIBODY; PLASMA PROTEIN; PROTEIN P155; UNCLASSIFIED DRUG;

ARTICLE; CANCER; CAUCASIAN; CAUSAL ATTRIBUTION; CLINICAL ASSESSMENT; CONNECTIVE TISSUE DISEASE; CONTROLLED STUDY; DERMATOMYOSITIS; DISEASE ASSOCIATION; HLA SYSTEM; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOGENETICS; IMMUNOPRECIPITATION; LUPUS VULGARIS; MAJOR CLINICAL STUDY; POLYMYOSITIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; RISK FACTOR; SERODIAGNOSIS;

ADULT; ANTIBODY SPECIFICITY; ANTIGENS; AUTOANTIBODIES; CHILD; DERMATOMYOSITIS; HUMANS; MASS SCREENING; MOLECULAR WEIGHT;

EID: 33750950507     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.22164     Document Type: Article

References (31)

1. Targoff IN. Idiopathic inflammatory myopathy: autoantibody update. Curr Rheumatol Rep 2002;4:434-41.
2. Targoff IN. Laboratory testing in the diagnosis and management of idiopathic inflammatory myopathies. Rheum Dis Clin North Am 2002;28:859-90.
3. Love LA, Leff RL, Fraser DD, Targoff IN, Dalakas MC, Plotz PH, et al. A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups. Medicine (Baltimore) 1991;70:360-74.
4. Reichlin M, Arnett FC Jr. Multiplicity of antibodies in myositis sera. Arthritis Rheum 1984;27:1150-6.
5. Brouwer R, Hengstman GJ, Vree E, Ehrfeld H, Bozic B, Ghirardello A, et al. Autoantibody profiles in the sera of European patients with myositis. Ann Rheum Dis 2001;60:116-23.
6. Mierau R, Dick T, Bartz-Bazzanella P, Keller E, Albert ED, Genth E. Strong association of dermatomyositis-specific Mi-2 autoantibodies with a tryptophan at position 9 of the HLA-DR β chain. Arthritis Rheum 1996;39:868-76.
7. Arnett FC, Targoff IN, Mimori T, Goldstein R, Warner NB, Reveille JD. Interrelationship of major histocompatibility complex class II alleles and autoantibodies in four ethnic groups with various forms of myositis. Arthritis Rheum 1996;39:1507-18.
8. Okada S, Weatherhead E, Targoff IN, Wesley R, Miller FW, for the International Myositis Collaborative Study Group. Global surface ultraviolet radiation intensity may modulate the clinical and immunologic expression of autoimmune muscle disease. Arthritis Rheum 2003;48:2285-93.
9. Feldman BM, Reichlin M, Laxer RM, Targoff IN, Stein LD, Silverman ED. Clinical significance of specific autoantibodies in juvenile dermatomyositis. J Rheumatol 1996;23:1794-7.
10. Rider LG, Miller FW. Classification and treatment of the juvenile idiopathic inflammatory myopathies. Rheum Dis Clin North Am 1997;23:619-55.
11. Bohan A, Peter JB. Polymyositis and dermatomyositis: I. N Engl J Med 1975;292:344-7.
12. Bohan A, Peter JB. Polymyositis and dermatomyositis: II. N Engl J Med 1975;292:403-7.
13. Targoff IN, Trieu EP, Miller FW. Reaction of anti-OJ autoantibodies with components of the multi-enzyme complex of amino-acyl-tRNA synthetases in addition to isoleucyl-tRNA synthetase. J Clin Invest 1993;91:2556-64.
14. Targoff IN. Autoantibodies to aminoacyl-transfer RNA synthetases for isoleucine and glycine: two additional synthetases are antigenic in myositis. J Immunol 1990;144:1737-43.
15. Nilasena DS, Trieu EP, Targoff IN. Analysis of the Mi-2 autoantigen of dermatomyositis. Arthritis Rheum 1995;38:123-8.
16. Olerup O, Aldener A, Fogdell A. HLA-DQB1 and -DQA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours. Tissue Antigens 1993;41:119-34.
17. Rider LG, Shamim E, Okada S, Pandey JP, Targoff IN, O'Hanlon TP, et al. Genetic risk and protective factors for idiopathic inflammatory myopathy in Koreans and American whites: a tale of two loci. Arthritis Rheum 1999;42:1285-90.
18. Shamim EA, Rider LG, Pandey JP, O'Hanlon TP, Jara LJ, Samayoa EA, et al. Differences in idiopathic inflammatory myopathy phenotypes and genotypes between Mesoamerican Mestizos and North American Caucasians: ethnogeographic influences in the genetics and clinical expression of myositis. Arthritis Rheum 2002;46:1885-93.
19. Kao AH, Lacomis D, Lucas M, Fertig N, Oddis CV. Anti-signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy. Arthritis Rheum 2004;50:209-15.
20. Hirakata M, Suwa A, Sato S, Nojima T, Kaneko Y, Akizuki M, et al. Clinical features of Japanese patients with anti-SRP autoantibodies: the immunogenetic backgrounds [abstract]. Arthritis Rheum 2002;46 Suppl 9:S611.
21. Friedman AW, Targoff IN, Arnett FC. Interstitial lung disease with autoantibodies against aminoacyl-tRNA synthetases in the absence of clinically apparent myositis. Semin Arthritis Rheum 1996;26:459-67.
22. Cambridge G, Ovadia E, Isenberg DA, Dubowitz V, Sperling J, Sperling R. Juvenile dermatomyositis: serial studies of circulating autoantibodies to a 56kD nuclear protein. Clin Exp Rheumatol 1994;12:451-7.
23. Arad-Dann H, Isenberg DA, Shoenfeld Y, Offen D, Sperling J, Sperling R. Autoantibodies against a specific nuclear RNP protein in sera of patients with autoimmune rheumatic disease associated with myositis. J Immunol 1987;138:2463-8.
24. Arad-Dann H, Isenberg D, Ovadia E, Shoenfeld Y, Sperling J, Sperling R. Autoantibodies against, a nuclear 56-kDa protein: a marker for inflammatory muscle disease. J Autoimmun 1989;2:877-88.
25. Hirakata M, Mimori T, Akizuki M, Craft J, Hardin JA, Homma M. Autoantibodies to small nuclear and cytoplasmic ribonucleoproteins in Japanese patients with inflammatory muscle disease. Arthritis Rheum 1992;35:449-56.
26. Rider LG, Miller FW, Targoff IN, Sherry DD, Samayoa E, Lindahl M, et al. A broadened spectrum of juvenile myositis: myositis-specific autoantibodies in children. Arthritis Rheum 1994;37:1534-8.
27. Sato S, Hirakata M, Kuwana M, Suwa A, Inada S, Mimori T, et al. Autoantibodies to a 140-kd polypeptide, CADM-140, in Japanese patients with clinically amyopathic dermatomyositis. Arthritis Rheum 2005;52:1571-6.
28. Espada G, Confalone Gregorian M, Ortiz Z, Fertig N, Londino AV, Oddis CV, et al. Serum autoantibodies in juvenile idiopathic inflammatory myopathies (UM) in a cohort of Argentine patients [abstract]. Arthritis Rheum 1997;40 Suppl 9:S140.
29. Oddis CV, Fertig N, Goel A, Espada G, Confalone Gregorian M, Maldonado Cocco JA, et al. Clinical and serological characterization of the anti-MJ antibody in childhood myositis [abstract]. Arthritis Rheum 1997;40 Suppl 9:S139.
30. Casciola-Rosen L, Nagaraju K, Plotz P, Wang K, Levine S, Gabrielson E, et al. Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. J Exp Med 2005;201:591-601.
31. Kaji K, Fujimoto M, Hasegawa M, Kondo M, Saito Y, Komura K, et al. Identification of a novel autoantibody reactive with 155 and 140 kDa nuclear proteins in patients with dermatomyositis: an association with malignancy. Rheumatology (Oxford) 2006. Epub ahead of print.