-
1
-
-
0038630396
-
Artemisinin, a novel antimalarial drug: Biochmical and molecular approaches for enhanced production
-
Abdin M. Z, Israr M, Rehman RU, Jain SK. 2003. Artemisinin, a novel antimalarial drug: biochmical and molecular approaches for enhanced production. Planta Med. 69:289-299.
-
(2003)
Planta Med.
, vol.69
, pp. 289-299
-
-
Abdin, M.Z.1
Israr, M.2
Rehman, R.U.3
Jain, S.K.4
-
2
-
-
35948997350
-
Metabolic engineering of biosynthetic pathways leading to isoprenoids: Mono-and sesquiterpenes in plastids and cytosol
-
Akhila A. 2007. Metabolic engineering of biosynthetic pathways leading to isoprenoids: mono-and sesquiterpenes in plastids and cytosol. J Plant Interact. 2:195-204.
-
(2007)
J Plant Interact.
, vol.2
, pp. 195-204
-
-
Akhila, A.1
-
3
-
-
0001764135
-
Biosynthesis of artemisinic acid in Artemisia annua
-
Akhila A., Kumkum R, Thakur RS. 1990. Biosynthesis of artemisinic acid in Artemisia annua. Phytochemistry. 29:2129-2132.
-
(1990)
Phytochemistry.
, vol.29
, pp. 2129-2132
-
-
Akhila, A.1
Kumkum, R.2
Thakur, R.S.3
-
4
-
-
80052703808
-
Over-expression of HMG-CoA reductase and amorpha-4, 11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content
-
Alam P., Abdin MZ. 2011. Over-expression of HMG-CoA reductase and amorpha-4, 11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content. Plant Cell Rep. 30:1919-1928.
-
(2011)
Plant Cell Rep.
, vol.30
, pp. 1919-1928
-
-
Alam, P.1
Abdin, M.Z.2
-
5
-
-
70449338387
-
Overexpression of the HMG-CoA reductase gene leads to enhanced artemisinin biosynthesis in transgenic Artemisia annua plants
-
Aquil S., Husaini AM, Abdin MZ, Rather GM. 2009. Overexpression of the HMG-CoA reductase gene leads to enhanced artemisinin biosynthesis in transgenic Artemisia annua plants. Planta Med. 75:1-6.
-
(2009)
Planta Med.
, vol.75
, pp. 1-6
-
-
Aquil, S.1
Husaini, A.M.2
Abdin, M.Z.3
Rather, G.M.4
-
6
-
-
77951821471
-
Effect of sugars on artemisinin production in Artemisia annua L.: Transcription and metabolite measurements
-
Arsenault P. R, Vail DR, Wobbe KK, Weathers PJ. 2010. Effect of sugars on artemisinin production in Artemisia annua L.: transcription and metabolite measurements. Molecules. 15:2302-2318.
-
(2010)
Molecules.
, vol.15
, pp. 2302-2318
-
-
Arsenault, P.R.1
Vail, D.R.2
Wobbe, K.K.3
Weathers, P.J.4
-
7
-
-
0030865006
-
Agrobacterium rhizogenes-mediated transformation of Artemisia annua: Production of transgenic plants
-
Banerjee S., Zehra M, Gupta MM, Kumar S. 1997. Agrobacterium rhizogenes-mediated transformation of Artemisia annua: production of transgenic plants. Planta Med. 63:467-469.
-
(1997)
Planta Med.
, vol.63
, pp. 467-469
-
-
Banerjee, S.1
Zehra, M.2
Gupta, M.M.3
Kumar, S.4
-
8
-
-
13544263331
-
Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua
-
Bertea C. M, Freije JR, van der Woude H, Verstappen FW, Perk L, Marquez V, De Kraker JW, Posthumus MA, Jansen BJ, de Groot A., Franssen MC, Bouwmeester HJ. 2005. Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua. Planta Med. 71:40-47.
-
(2005)
Planta Med.
, vol.71
, pp. 40-47
-
-
Bertea, C.M.1
Freije, J.R.2
van der Woude, H.3
Verstappen, F.W.4
Perk, L.5
Marquez, V.6
De Kraker, J.W.7
Posthumus, M.A.8
Jansen, B.J.9
de Groot, A.10
Franssen, M.C.11
Bouwmeester, H.J.12
-
9
-
-
78649475176
-
The biosynthesis of artemisinin (Qinghaosu) and the phytochemistry of Artemisia annua L. (Qinghao)
-
Brown G.D. 2010. The biosynthesis of artemisinin (Qinghaosu) and the phytochemistry of Artemisia annua L. (Qinghao). Molecules. 15:7603.
-
(2010)
Molecules.
, vol.15
, pp. 7603
-
-
Brown, G.D.1
-
10
-
-
0346964232
-
In vivo transformations of dihydroartemisinic acid in Artemisia annua plants
-
Brown G. D, Sy LK. 2004. In vivo transformations of dihydroartemisinic acid in Artemisia annua plants. Tetrahedron. 60:1139-1159.
-
(2004)
Tetrahedron.
, vol.60
, pp. 1139-1159
-
-
Brown, G.D.1
Sy, L.K.2
-
11
-
-
34547699424
-
In vivo transformations of artemisinic acid in Artemisia annua plants
-
Brown G. D, Sy LK. 2007. In vivo transformations of artemisinic acid in Artemisia annua plants. Tetrahedron. 63:9548-9566.
-
(2007)
Tetrahedron.
, vol.63
, pp. 9548-9566
-
-
Brown, G.D.1
Sy, L.K.2
-
12
-
-
0034729780
-
Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation
-
Chen D., Ye H, Li G. 2000. Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation. Plant Sci. 155:179-185.
-
(2000)
Plant Sci.
, vol.155
, pp. 179-185
-
-
Chen, D.1
Ye, H.2
Li, G.3
-
13
-
-
0033490597
-
Ri-mediated transformation of Artemisia annua with a recombinant farnesyl diphosphate synthase gene for artemisinin production
-
Chen D. H, Liu CJ, Ye HC, Li GF, Liu BY, Meng YL, Chen XY. 1999. Ri-mediated transformation of Artemisia annua with a recombinant farnesyl diphosphate synthase gene for artemisinin production. Plant Cell Tissue Organ Cult. 7:157-162.
-
(1999)
Plant Cell Tissue Organ Cult.
, vol.7
, pp. 157-162
-
-
Chen, D.H.1
Liu, C.J.2
Ye, H.C.3
Li, G.F.4
Liu, B.Y.5
Meng, Y.L.6
Chen, X.Y.7
-
14
-
-
0035214127
-
New trends in extraction, identification and quantification of artemisinin and its derivatives
-
Christen P., Veuthey JL. 2001. New trends in extraction, identification and quantification of artemisinin and its derivatives. Curr Med Chem. 8:1827-1839.
-
(2001)
Curr Med Chem.
, vol.8
, pp. 1827-1839
-
-
Christen, P.1
Veuthey, J.L.2
-
15
-
-
0035086303
-
Effects of ipt gene expression on the physiological and chemical characteristics of Artemisia annua L
-
Geng S., Ma M, Ye HC, Liu BY, Li GF, Chong K. 2001. Effects of ipt gene expression on the physiological and chemical characteristics of Artemisia annua L. Plant Sci. 160:691-698.
-
(2001)
Plant Sci.
, vol.160
, pp. 691-698
-
-
Geng, S.1
Ma, M.2
Ye, H.C.3
Liu, B.Y.4
Li, G.F.5
Chong, K.6
-
16
-
-
78651504314
-
Impact of organic manure and chemical fertilizers on artemisinin content and yield in Artemisia annua L
-
Jha P., Ram M, Khan MA, Kiran U, Mahamooduzzafar, Abdin MZ. 2010. Impact of organic manure and chemical fertilizers on artemisinin content and yield in Artemisia annua L. Ind Crops Prod. 33:296-301.
-
(2010)
Ind Crops Prod.
, vol.33
, pp. 296-301
-
-
Jha, P.1
Ram, M.2
Khan, M.A.3
Kiran, U.4
Mahamooduzzafar, A.M.Z.5
-
17
-
-
0023236182
-
Effect of sterol inhibitors on the incorporation of 14C-isopentenyl pyrophosphate into artemisinin by a cell-free system from Artemisia annua tissue cultures and plants
-
Kudakasseril G. J, Lam L, Staba EJ. 1987. Effect of sterol inhibitors on the incorporation of 14C-isopentenyl pyrophosphate into artemisinin by a cell-free system from Artemisia annua tissue cultures and plants. Planta Med. 53:280-284.
-
(1987)
Planta Med.
, vol.53
, pp. 280-284
-
-
Kudakasseril, G.J.1
Lam, L.2
Staba, E.J.3
-
18
-
-
0022996771
-
Formation of artemisinin in Artemisia annua during one vegetation period
-
Liersch R., Soicke H, Stehr C, Tullner HV. 1986. Formation of artemisinin in Artemisia annua during one vegetation period. Planta Med. 52:387-390.
-
(1986)
Planta Med.
, vol.52
, pp. 387-390
-
-
Liersch, R.1
Soicke, H.2
Stehr, C.3
Tullner, H.V.4
-
19
-
-
40649126955
-
Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry
-
Ma C., Wang H, Lu X, Xu G, Liu B. 2008. Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry. J Chromatogr A. 1186:412-419.
-
(2008)
J Chromatogr A.
, vol.1186
, pp. 412-419
-
-
Ma, C.1
Wang, H.2
Lu, X.3
Xu, G.4
Liu, B.5
-
20
-
-
0029083283
-
Understanding and controlling transgene expression
-
Meyer P. 1995. Understanding and controlling transgene expression. Trends Biotechnol. 13:332-337.
-
(1995)
Trends Biotechnol.
, vol.13
, pp. 332-337
-
-
Meyer, P.1
-
21
-
-
0003191790
-
Seasonal accumulation of artemisinin in Artemisia annua L
-
Morales M. R, Charles DJ, Simon JE. 1993. Seasonal accumulation of artemisinin in Artemisia annua L. Acta Hort. 344:416-420.
-
(1993)
Acta Hort.
, vol.344
, pp. 416-420
-
-
Morales, M.R.1
Charles, D.J.2
Simon, J.E.3
-
22
-
-
78751585312
-
Enhancement of artemisinin content by constitutive expression of HMG-CoA reductase gene in high-yielding strain of Artemisia annua L
-
Nafis T., Akmal M, Ram M, Alam P, Ahlawat S, Mohammad A, Abdin MZ. 2011. Enhancement of artemisinin content by constitutive expression of HMG-CoA reductase gene in high-yielding strain of Artemisia annua L. Plant Biotechnol Rep. 5:53-60.
-
(2011)
Plant Biotechnol Rep.
, vol.5
, pp. 53-60
-
-
Nafis, T.1
Akmal, M.2
Ram, M.3
Alam, P.4
Ahlawat, S.5
Mohammad, A.6
Abdin, M.Z.7
-
23
-
-
84904464843
-
-
NIST02. Gaithersburg (MD): National Institute of Standards and Technology
-
NIST02. 2008. Mass spectral database. Gaithersburg (MD): National Institute of Standards and Technology.
-
(2008)
Mass spectral database.
-
-
-
24
-
-
69249228525
-
Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisa annua L
-
Olsson M. E, Olofsson LM, Lindahl AL, Lundgren A, Brodelius M, Brodelius PE. 2009. Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisa annua L. Phytochemistry. 70:1123.
-
(2009)
Phytochemistry.
, vol.70
, pp. 1123
-
-
Olsson, M.E.1
Olofsson, L.M.2
Lindahl, A.L.3
Lundgren, A.4
Brodelius, M.5
Brodelius, P.E.6
-
25
-
-
33646148490
-
Amorpha-4, 11-diene synthase: Mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate
-
Picaud S., Mercke P, He X, Sterner O, Brodelius M, Cane DE, Brodelius P.E. 2006. Amorpha-4, 11-diene synthase: mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate. Arch Biochem Biophys. 448:150-155.
-
(2006)
Arch Biochem Biophys.
, vol.448
, pp. 150-155
-
-
Picaud, S.1
Mercke, P.2
He, X.3
Sterner, O.4
Brodelius, M.5
Cane, D.E.6
Brodelius, P.E.7
-
26
-
-
78049260491
-
HMG-CoA reductase limits artemisinin biosynthesis and accumulation in Artemisia annua L
-
Ram M., Khan MA, Jha P, Khan S. 2010. HMG-CoA reductase limits artemisinin biosynthesis and accumulation in Artemisia annua L. Plants Acta Physiol Plant. 32:859-866.
-
(2010)
Plants Acta Physiol Plant.
, vol.32
, pp. 859-866
-
-
Ram, M.1
Khan, M.A.2
Jha, P.3
Khan, S.4
-
27
-
-
80054043776
-
Volatile fingerprints of artemisinin-rich Artemisia annua cultivars by headspace solid-phase microextraction gas chromatography mass spectrometry
-
Reale S., Fasciani P, Pace L, De Angelis F, Marcozzi G. 2011. Volatile fingerprints of artemisinin-rich Artemisia annua cultivars by headspace solid-phase microextraction gas chromatography mass spectrometry. Rapid Commun Mass Spectrom. 25:2511-2516.
-
(2011)
Rapid Commun Mass Spectrom.
, vol.25
, pp. 2511-2516
-
-
Reale, S.1
Fasciani, P.2
Pace, L.3
De Angelis, F.4
Marcozzi, G.5
-
28
-
-
33947307759
-
Plant metabolomics: Towards biological function and mechanism
-
Schauer N., Fernie AR. 2006. Plant metabolomics: towards biological function and mechanism. Trends Plant Sci. 11:508-516.
-
(2006)
Trends Plant Sci.
, vol.11
, pp. 508-516
-
-
Schauer, N.1
Fernie, A.R.2
-
29
-
-
73849101954
-
Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study
-
Schramek N., Wang H, Römisch-Margl W, Keil B, Radykewicz T, Winzenhörlein B, Beerhues L, Bacher A, Rohdich F, Gershenzon J., Liu B, Eisenreich W. 2010. Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. Phytochemistry. 71:179-187.
-
(2010)
Phytochemistry.
, vol.71
, pp. 179-187
-
-
Schramek, N.1
Wang, H.2
Römisch-Margl, W.3
Keil, B.4
Radykewicz, T.5
Winzenhörlein, B.6
Beerhues, L.7
Bacher, A.8
Rohdich, F.9
Gershenzon, J.10
Liu, B.11
Eisenreich, W.12
-
30
-
-
0026087373
-
Rapid method for the detection and determination of artemisinin by gas chromatography
-
Sipahimalani A. T, Fulzele DP, Heble MR. 1991. Rapid method for the detection and determination of artemisinin by gas chromatography. J Chromatogr. 538:452-455.
-
(1991)
J Chromatogr.
, vol.538
, pp. 452-455
-
-
Sipahimalani, A.T.1
Fulzele, D.P.2
Heble, M.R.3
-
31
-
-
0030021267
-
Nuclear matric attachment regions and transgene expression in plants
-
Spiker S., Thompson WF. 1996. Nuclear matric attachment regions and transgene expression in plants. Plant Physiol. 110:15-21.
-
(1996)
Plant Physiol.
, vol.110
, pp. 15-21
-
-
Spiker, S.1
Thompson, W.F.2
-
32
-
-
68149089486
-
Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annua
-
Teoh K. T, Polichuk DR, Reed DW, Covello PS. 2009. Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annua. Botany. 87:635-642.
-
(2009)
Botany.
, vol.87
, pp. 635-642
-
-
Teoh, K.T.1
Polichuk, D.R.2
Reed, D.W.3
Covello, P.S.4
-
33
-
-
36448939464
-
Evidence of artemisinin production from IPP stemming from both the mevalonate and the non mevalonate pathways
-
Towler M. J, Weathers PJ. 2007. Evidence of artemisinin production from IPP stemming from both the mevalonate and the non mevalonate pathways. Plant Cell Rep. 26:2129-2136.
-
(2007)
Plant Cell Rep.
, vol.26
, pp. 2129-2136
-
-
Towler, M.J.1
Weathers, P.J.2
-
34
-
-
33646940163
-
Quantitation of artemisinin and its biosynthetic precursors in Artemisia annua L. by high performance liquid chromatography-electrospray quadrupole time-of-flight tandem mass spectrometry
-
Van Nieuwerburgh F. CW, Vande Casteele SRF, Maes L, Goossens A, Inze D, Van Bocxlaer J, Deforce DLD. 2006. Quantitation of artemisinin and its biosynthetic precursors in Artemisia annua L. by high performance liquid chromatography-electrospray quadrupole time-of-flight tandem mass spectrometry. J Chromatogr. 1118:180-187.
-
(2006)
J Chromatogr.
, vol.1118
, pp. 180-187
-
-
Van Nieuwerburgh, F.C.W.1
Vande Casteele, S.R.F.2
Maes, L.3
Goossens, A.4
Inze, D.5
Van Bocxlaer, J.6
Deforce, D.L.D.7
-
35
-
-
0035129779
-
Amorpha-4, 11-diene synthase: Cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel anti-malarial drug artemisinin
-
Wallaart T. E, Bouwmeester HJ, Hille J, Poppinga L, Maijers NC. 2001. Amorpha-4, 11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel anti-malarial drug artemisinin. Planta. 212:460-465.
-
(2001)
Planta.
, vol.212
, pp. 460-465
-
-
Wallaart, T.E.1
Bouwmeester, H.J.2
Hille, J.3
Poppinga, L.4
Maijers, N.C.5
-
36
-
-
2342501740
-
Studies on the effects of fpf1 gene on Artemisia annua flowering time and on the linkage between flowering and artemisinin biosynthesis
-
Wang H., Ge L, Ye HC, Chong K, Liu BY, Li GF. 2004. Studies on the effects of fpf1 gene on Artemisia annua flowering time and on the linkage between flowering and artemisinin biosynthesis. Planta Med. 70:347-352.
-
(2004)
Planta Med.
, vol.70
, pp. 347-352
-
-
Wang, H.1
Ge, L.2
Ye, H.C.3
Chong, K.4
Liu, B.Y.5
Li, G.F.6
-
37
-
-
34249700702
-
Earlier flowering induced by over-expression of CO gene does not accompany increase of artemisinin biosynthesis in Artemisia annua
-
Wang H., Liu Y, Chong K, Liu BY, Ye HC, Li ZQ, Yan F, Li GF. 2007. Earlier flowering induced by over-expression of CO gene does not accompany increase of artemisinin biosynthesis in Artemisia annua. Plant biol. 9:442-446.
-
(2007)
Plant biol.
, vol.9
, pp. 442-446
-
-
Wang, H.1
Liu, Y.2
Chong, K.3
Liu, B.Y.4
Ye, H.C.5
Li, Z.Q.6
Yan, F.7
Li, G.F.8
-
38
-
-
79958060183
-
Artemisinin production in Artemisia annua: Studies in planta and results of a novel delivery method for treating malaria and other neglected diseases
-
Weathers P. J, Arsenault PR, Covello PS, McMickle A, Teoh KH, Reed DW. 2011. Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases. Phytochem Rev. 10:173-182.
-
(2011)
Phytochem Rev.
, vol.10
, pp. 173-182
-
-
Weathers, P.J.1
Arsenault, P.R.2
Covello, P.S.3
McMickle, A.4
Teoh, K.H.5
Reed, D.W.6
-
39
-
-
0003738436
-
-
In McLafferty FW, Stauffer DB, editors. Wiley/NBS Registry of Mass Spectral Data. New York (NY): John Wiley
-
Wiley. 1989. Registry of mass spectral data. In McLafferty FW, Stauffer DB, editors. Wiley/NBS Registry of Mass Spectral Data. New York (NY): John Wiley.
-
(1989)
Registry of mass spectral data.
-
-
Wiley1
-
40
-
-
0011242658
-
Mevalonic acid concentrations in fruit and vegetable tissues
-
Wills R. BH, Scurr EV. 1975. Mevalonic acid concentrations in fruit and vegetable tissues. Phytochem Rep. 14:1643.
-
(1975)
Phytochem Rep.
, vol.14
, pp. 1643
-
-
Wills, R.B.H.1
Scurr, E.V.2
-
41
-
-
52049090608
-
The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome dependent biosynthesis of artemisinin in Artemisia annua
-
Zhang Y., Teoh KH, Reed DW, Maes L, Goossens A, Olson DJ, Ross A. R, Covello PS. 2008. The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome dependent biosynthesis of artemisinin in Artemisia annua. J Biol Chem. 283:21501-21508.
-
(2008)
J Biol Chem.
, vol.283
, pp. 21501-21508
-
-
Zhang, Y.1
Teoh, K.H.2
Reed, D.W.3
Maes, L.4
Goossens, A.5
Olson, D.J.6
Ross, A.R.7
Covello, P.S.8
-
42
-
-
2342554190
-
Determination of qinghaosu in Artemisia annua L. by high performance liquid chromatography
-
Zhao S. S, Zeng MY. 1986. Determination of qinghaosu in Artemisia annua L. by high performance liquid chromatography. Chin J Pharm Anal. 6:3-5.
-
(1986)
Chin J Pharm Anal.
, vol.6
, pp. 3-5
-
-
Zhao, S.S.1
Zeng, M.Y.2
|