Upper gastrointestinal bleeding in hospital inpatients: The role of antithrombotic drugs

Postgraduate Medical Journal

Volumn 90, Issue 1066, 2014, Pages 429-433

  Taha, Ali S ^a   Kelly, Claire ^a   McCloskey, Caroline ^a   Craigen, Theresa ^a   Angerson, Wilson J ^b  

^a CROSSHOUSE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; CLOPIDOGREL; DALTEPARIN; DIPYRIDAMOLE; FRESH FROZEN PLASMA; HISTAMINE H2 RECEPTOR ANTAGONIST; LOW MOLECULAR WEIGHT HEPARIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROTON PUMP INHIBITOR; SEROTONIN UPTAKE INHIBITOR; VITAMIN K GROUP; WARFARIN; ANTITHROMBOCYTIC AGENT; ANTIULCER AGENT;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; CARDIOVASCULAR DISEASE; DRUG USE; DUODENUM ULCER; FEMALE; GASTROINTESTINAL ENDOSCOPY; GENDER; HOSPITAL PATIENT; HUMAN; INTENSIVE CARE UNIT; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PREVALENCE; PROTHROMBIN TIME; REFLUX ESOPHAGITIS; ROCKALL SCORE; SCORING SYSTEM; STOMACH ULCER; UPPER GASTROINTESTINAL BLEEDING; BLOOD TRANSFUSION; CHEMICALLY INDUCED; DRUG ADMINISTRATION; GASTROINTESTINAL HEMORRHAGE; MIDDLE AGED; RISK FACTOR; STATISTICS AND NUMERICAL DATA;

AGE FACTORS; AGED; ANTI-ULCER AGENTS; ANTICOAGULANTS; BLOOD TRANSFUSION; DRUG ADMINISTRATION SCHEDULE; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMANS; INPATIENTS; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; RISK FACTORS; STOMACH ULCER;

EID: 84904472283     PISSN: 00325473     EISSN: 14690756     Source Type: Journal    
DOI: 10.1136/postgradmedj-2013-132231     Document Type: Article

References (16)

1. Taha AS, Angerson WJ, Prasad R, et al. Upper gastrointestinal bleeding and the changing use of COX-2 non-steroidal anti-inflammatory drugs and low-dose aspirin. Aliment Pharmacol Ther 2007;26:1171-8.
2. Lanas A, Garcia-Rodriguez LA, Polo-Tomas M, et al. The changing face of hospitalization due to gastrointestinal bleeding and perforation. Aliment Pharmacol Ther 2011;33:585-91.
3. Abraham NS, Hartman C, Harsche J. Reduced hospitalization cost for upper gastrointestinal events that occur among elderly veterans who are gastroprotected. Clin Gastroenterol Hepatol 2010;8:350-6.
4. Rockall TA, Logan RFA, Devlin HB, et al. Selection of patients for early discharge or outpatient care after acute upper gastrointestinal haemorrhage. Lancet 1996;347:1138-40.
5. Blatchford O, Murray WR, Blatchford M. A risk score to predict need for treatment for upper gastrointestinal haemorrhage. Lancet 2000;356:1316-21.
6. Muller T, Barkun AN, Martel M; the RUGBE investigators. Non-variceal upper GI bleeding in patients already hospitalized for another condition. Am J Gastroenterol 2009;104:330-9.
7. Cook DJ, Fuller HD, Guyatt GH, et al. Risk factors for gastrointestinal bleeding in critically ill patients. Canadian Critical Care Trials Group. N Engl J Med 1994;330:377-81.
8. Pimentel M, Roberts DE, Bernstein CN, et al. Clinically significant gastrointestinal bleeding in critically ill patients in an era of prophylaxis. Am J Gastroenterol 2000;95:2801-6.
9. Taha AS, McCloskey C, Craigen T, et al. Mortality following blood transfusion for non-variceal upper gastrointestinal bleeding. Frontline Gastroenterology 2011;2:218-25.
10. Taha AS, Kelly C, McCloskey C, et al. Gastroprotective policy and the incidence of upper gastrointestinal bleeding. Frontline Gastroenterology 2013;4:108-11.
11. Hsieh FY, Bloch DA, Larsen MD. A simple method of sample size calculation for linear and logistic regression. Statist Med 1998;17:1623-34.
12. Qadeer MA, Richter JE, Brotman DJ. Hospital acquired gastrointestinal bleeding outside the critical care unit. J Hosp Med 2006;1:13-20.
13. Taha AS, McCloskey C, Prasad R, et al. Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase-III, randomised, double-blind, placebo-controlled trial. Lancet 2009;374:119-25.
14. FDA. Proton Pump Inhibitors (PPIs)-Drug Safety Communication: Clostridium Difficile-Associated Diarrhea (CDAD) Can be Associated With Stomach Acid Drugs. 2012. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm290838.htm?source=govdelivery (accessed 4 Jun 2013).
15. Kwok CS, Arthur AK, Anibueze CI, et al. Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis. Am J Gastroenterol 2012;107:1011-19.
16. Wilcox CM, Allison J, Benzully K, et al. Consensus development conference on the use of non-steroidal antiinflammatory agents, including cyclooxygenase-2 enzyme inhibitors and aspirin. Clin Gastroenterol Hepatol 2006;4:1082-9.