The genetic variation of ARRB2 is associated with late-onset Alzheimer's disease in Han Chinese

Current Alzheimer Research

Volumn 11, Issue 4, 2014, Pages 408-412

  Jiang, Teng ^a   Yu, Jin Tai ^a,b,c   Wang, Ying Li ^b   Wang, Hui Fu ^b   Zhang, Wei ^b   Hu, Nan ^b   Tan, Lin ^b   Sun, Lei ^b   Tan, Meng Shan ^c   Zhu, Xi Chen ^a   Tan, Lan ^a,b,c  

^a NANJING MEDICAL UNIVERSITY   (China)

^b QINGDAO UNIVERSITY   (China)

^c OCEAN UNIVERSITY OF CHINA   (China)

Author keywords

Alzheimer's disease; Association; Gene; Polymorphism; arrestin 2; secretase

Indexed keywords

APOLIPOPROTEIN E4; BETA ARRESTIN 2; BETA ARRESTIN; RETINA S ANTIGEN;

AGE; AGED; ALZHEIMER DISEASE; ARTICLE; BETA ARRESTIN 2 GENE; CONTROLLED STUDY; EDUCATION; FEMALE; GENDER; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAN CHINESE; HAPLOTYPE; HAPLOTYPE MAP; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; VERY ELDERLY; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; EDUCATIONAL STATUS; GENETIC PREDISPOSITION; GENETICS; GENOTYPING TECHNIQUE; ONSET AGE; SEX DIFFERENCE;

AGE FACTORS; AGE OF ONSET; AGED; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; ARRESTINS; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; EDUCATIONAL STATUS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPING TECHNIQUES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX FACTORS;

EID: 84904465930     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/1567205011666140317095014     Document Type: Article

References (22)

1. Jiang T, Yu JT, Tian Y, Tan L. Epidemiology and Etiology of Alzheimer's disease: From Genetic to Non- Genetic Factors. Curr Alzheimer Res 10(8): 852-67 (2013).
2. Thies W, aBleiler L. Alzheimer's disease facts and figures. Alzheimers Dement 9(2): 208-45 (2013).
3. Bihaqi SW, Schumacher A, Maloney B, Lahiri DK, Zawia NH. Do epigenetic pathways initiate late onset Alzheimer disease (LOAD): towards a new paradigm. Curr Alzheimer Res 9(5): 574-88 (2012).
4. Gatz M, Reynolds CA, Fratiglioni L, Johansson B, Mortimer JA, Berg S, et al. Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry 63(2): 168-74 (2006).
5. Hauser PS, Ryan RO. Impact of apolipoprotein E on Alzheimer's disease. Curr Alzheimer Res 10(8): 809-17 (2013).
6. Walther C, Ferguson SS. Arrestins: role in the desensitization, sequestration, and vesicular trafficking of G protein-coupled receptors. Prog Mol Biol Transl Sci 118: 93-113 (2013).
7. Liu X, Zhao X, Zeng X, Bossers K, Swaab DF, Zhao J, et al. beta-Arrestin1 regulates gamma-secretase complex assembly and modulates amyloid-beta pathology. Cell Res 23(3): 351-65 (2013).
8. Thathiah A, Horre K, Snellinx A, Vandewyer E, Huang Y, Ciesielska M, et al. beta-arrestin 2 regulates Abeta generation and gamma-secretase activity in Alzheimer's disease. Nat Med 19(1): 43-9 (2013).
9. Gurevich EV, Benovic JL, Gurevich VV. Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development. Neuroscience 109(3): 421-36 (2002).
10. Jiang T, Yu JT, Tan MS, Zhu XC, Tan L. Beta-arrestins as potential therapeutic targets for Alzheimer's disease. Mol Neurobiol 48(3): 812-8 (2013).
11. Wang D, Yuen EY, Zhou Y, Yan Z, Xiang YK. Amyloid beta peptide-(1-42) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neurons. J Biol Chem 286(36): 31852-63 (2011).
12. Jiang T, Yu JT, Tan MS, Zhu XC, Tan L. beta-Arrestins as Potential Therapeutic Targets for Alzheimer's Disease. Mol Neurobiol, 10.1007/s12035-013-8469-8(2013).
13. Liou YJ, Wang YC, Chen JY, Chen ML, Chen TT, Bai YM, et al. The coding-synonymous polymorphism rs1045280 (Ser280Ser) in beta-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia. Eur J Neurol 15(12): 1406-8 (2008).
14. Brookes K, Xu X, Chen W, Zhou K, Neale B, Lowe N, et al. The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry 11(10): 934-53 (2006).
15. Ikeda M, Ozaki N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, et al. Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia. Genes Brain Behav 6(1): 107-12 (2007).
16. Ambrose-Lanci LM, Vaswani M, Clarke TK, Zeng A, Lohoff FW, Ferraro TN, et al. Association study of the beta-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population. Psychiatr Genet 22(3): 141-5 (2012).
17. Sun D, Ma JZ, Payne TJ, Li MD. Beta-arrestins 1 and 2 are associated with nicotine dependence in European American smokers. Mol Psychiatry 13(4): 398-406 (2008).
18. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34(7): 939-44 (1984).
19. Yu JT, Miao D, Cui WZ, Ou JR, Tian Y, Wu ZC, et al. Common variants in toll-like receptor 4 confer susceptibility to Alzheimer's disease in a Han Chinese population. Curr Alzheimer Res 9(4): 458-66 (2012).
20. Jiang T, Yu JT, Tan MS, Wang HF, Wang YL, Zhu XC, et al. Genetic variation in PICALM and Alzheimer's disease risk in Han Chinese. Neurobiol Aging 35(4): 934 e1-3 (2014).
21. Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, et al. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet 12(3): 205-16 (2003).
22. Capon F, Allen MH, Ameen M, Burden AD, Tillman D, Barker JN, et al. A synonymous SNP of the corneodesmosin gene leads to increased mRNA stability and demonstrates association with psoriasis across diverse ethnic groups. Hum Mol Genet 13(20): 2361-8 (2004).