Water for thought: Is there a role for aquaporin channels in delirium?

Frontiers in Psychiatry

Volumn 5, Issue MAY, 2014, Pages

  Sfera, Adonis ^a   Osorio, Carolina ^b  

^a PATTON STATE HOSPITAL   (United States)

^b KAISER PERMANENTE   (United States)

Author keywords

Acetylcholine; Aquaporin blockers; Aquaporins; Delirium; Neuroinflammation

Indexed keywords

ACETYLCHOLINE; AQUAPORIN 4; AQUAPORIN 4 ANTIBODY; ARYLSULFONAMIDE; PIROXICAM; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTE; ATTENTION DISTURBANCE; BRAIN ISCHEMIA; CHOLINERGIC TRANSMISSION; DELIRIUM; DISEASE ASSOCIATION; FUNCTIONS OF THE HEMIC, LYMPHATIC AND RETICULOENDOTHELIAL SYSTEMS; GLYMPHATIC CLEARANCE; GLYMPHATIC STASIS; HUMAN; MEMORY DISORDER; MICROGLIA; MOLECULAR PATHOLOGY; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; SEXUAL AROUSAL DISORDER; SLEEP DISORDER; WATER TRANSPORT;

EID: 84904465897     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2014.00057     Document Type: Article

References (45)

1. Jung CG. Archetypes of the Collective Unconscious. Collected Works of C. G. Jung. 2nd ed. (Vol. 9). New Jersey: Princeton University Press (1968). 451 p.
2. Dudek FE, Rogawski MA. Regulation of brain water: is there a role for aquaporins in epilepsy? Epilepsy Curr (2005) 5(3):104-6. doi:10.1111/j.1535-7511.2005.05310.x
3. Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, et al. Sleep drives metabolite clearance from the adult brain. Science (2013) 342:373-7. doi:10.1126/science.1241224
4. Yang L, Kress BT, Weber HJ, Thiyagarajan M, Wang B, Deane R, et al. Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer. J Transl Med (2013) 11(1):107. doi:10.1186/1479-5876-11-107
5. Iliff JJ, Hedok L, Yu M, Feng T, Logan J, Nedergaard M, et al. Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest (2013) 123:1299-309. doi:10.1172/JCI67677
6. Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, et al. Paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med (2012) 4:147ra111. doi:10.1126/scitranslmed.3003748
7. Taber KH, Hurley RA. Volume transmission in the brain: beyond the synapse. J Neuropsychiatry Clin Neurosci (2014) 26:4. doi:10.1176/appi.neuropsych.13110351
8. Perry VH, Holmes C. Microglial priming in neurodegenerative disease. Nat Rev Neurol (2014) 10:217-24. doi:10.1038/nrneurol.2014.38
9. Thomas DR, Cote TR, Lawhorne L, Levenson SA, Rubenstein LZ, Smith DA, et al. Understanding clinical dehydration and its treatment. J Am Med Dir Assoc (2008) 9(5):292-301. doi:10.1016/j.jamda.2008.03.006
10. Tourdias T, Mori N, Dragonu I, Cassagno N, Boiziau C, Aussudre J, et al. Differential aquaporin 4 expression during edema build-up and resolution phases of brain inflammation. J Neuroinflammation (2011) 8:143. doi:10.1186/1742-2094-8-143
11. Saito N, Ikegami H, Shimada K. Effect of water deprivation on aquaporin 4 (AQP4) mRNA expression in chickens (Gallus domesticus). Brain Res Mol Brain Res (2005) 141(2):193-7. doi:10.1016/j.molbrainres.2005.09.005
12. Umenishi F, Verkman AS, Gropper MA. Quantitative analysis of aquaporin mRNA expression in rat tissues by RNase protection assay. DNA Cell Biol (1996) 6:475-80. doi:10.1089/dna.1996.15.475
13. Kolber BJ, Key M, Yanfang C, Morris M, Krane C. Aquaporin 4 mRNA expression in mouse brain is induced in response to dehydration. FASEB J (2003) 17:4-5.
14. Fukuda AM, Badaut J. Aquaporin 4: a player in cerebral edema and neuroinflammation. J Neuroinflammation (2012) 9:279. doi:10.1186/1742-2094-9-279
15. Field RH, Gossen A, Cunningham C. Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium. J Neurosci (2012) 32(18):6288-94. doi:10.1523/JNEUROSCI.4673-11.2012
16. Lendvai B, Vizi ES. Nonsynaptic chemical transmission through nicotinic receptors. Physiol Rev (2008) 88:333-49. doi:10.1152/physrev.00040.2006
17. Agnati LF, Zoli M, Strömberg I, Fuxe K. Intercellular communication in the brain: wiring versus volume transmission. Neuroscience (1995) 69(3):711-26. doi:10.1016/0306-4522(95)00308-6
18. Hasselmo ME, McGaughy J. High acetylcholine sets circuit dynamics for attention and encoding; low acetylcholine sets dynamics for consolidation. Prog Brain Res (2004) 145:207-34. doi:10.1016/S0079-6123(03)45015-2
19. Trueta C, De-Miguel FF. Extrasynaptic exocytosis and its mechanisms: a source of molecules mediating volume transmission in the nervous system. Front Physiol (2012) 3:319. doi:10.3389/fphys.2012.00319
20. Maldonado JR. Pathoetiological model of delirium: a comprehensive understanding of the neurobiology of delirium and an evidence-based approach to prevention and treatment. Crit Care Clin (2008) 24(4):789-856. doi:10.1016/j.ccc.2008.06.004
21. Meshorer E, Inbal E, Biton IE, Ben-Shaul Y, Ben-Ari S, Assaf Y, et al. Chronic cholinergic imbalances promote brain diffusion and transport abnormalities. FASEB J (2005) 19(8):910-22. doi:10.1096/fj.04-2957comPubmed
22. Badauta J, Verbavatz JM, Freund-Merciera MJ, Lasbennesa F. Presence of aquaporin-4 and muscarinic receptors in astrocytes and ependymal cells in rat brain: a clue to a common function? Neurosci Lett (2000) 292(2):75-8.
23. van Gool WA. Brain disorders in critical illness. In: Stevens RD, Sharshar T, Wesley EE, editors. Mechanisms, Diagnosis, and Treatment. Cambridge: Cambridge University Press (2013). 141 p.
24. Tomás-Camardiel T, Venero JL, de Pablos RM, Rite I, Machado A, Cano J. In vivo expression of aquaporin-4 by reactive microglia. J Neurochem (2004) 91(4):891-9. doi:10.1111/j.1471-4159.2004.02759.x
25. van Eijk MM, Roes KC, Honing ML, Kuiper MA, Karakus A, van der Jagt M, et al. Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial. Lancet (2010) 376(9755):1829-37. doi:10.1016/S0140-6736(10)61855-7
26. Dilger RN, Johnson RW. Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol (2008) 84(4):932-9. doi:10.1189/jlb.0208108
27. Tang C, Zelenak C, Völkl J, Eichenmüller M, Regel I, Fröhlich H, et al. Hydration-sensitive gene expression in brain. Cell Physiol Biochem (2011) 27:757-68. doi:10.1159/000330084
28. Marinescu D, Mogoanta L, Sfera A, Gradini R, Osorio C, Preda A. An experimental model of ischemia-induced changes into the glymphatic system of the brain. Rom J Psychopharma (2013) 13(4):243-51.
29. Rao KVR, Norenberg MD. Aquaporin-4 in hepatic encephalopathy. Metab Brain Dis (2007) 22(3-4):265-75.
30. Rama KVR, Chen M, Simard JM, Norenberg MD. Increased aquaporin-4 expression in ammonia-treated cultured astrocytes. Neuroreport (2003) 14(18):2379-82.
31. Shenaqa M, Kassema H, Penga C, Schaferb S, Ding JY, Fredricksona V, et al. Neuronal damage and functional deficits are ameliorated by inhibition of aquaporin and HIF1α after traumatic brain injury (TBI). J Neurol Sci (2012) 323(1-2):134-40. doi:10.1016/j.jns.2012.08.036
32. Florence CM, Baillie LD, Mulligan SJ. Dynamic volume changes in astrocytes are an intrinsic phenomenon mediated by bicarbonate ion flux. PLoS One (2012) 7(11):e51124. doi:10.1371/journal.pone.0051124
33. Moftakhar P, Lynch MD, Pomakian JL, Vinters HV. Aquaporin expression in the brains of patients with or without cerebral amyloid angiopathy. J Neuropathol Exp Neurol (2010) 69(12):1201-9. doi:10.1097/NEN.0b013e3181fd252cPubmed
34. Gupta RK, Kanungo M. Glial molecular alterations with mouse brain development and aging: up-regulation of the Kir4.1 and aquaporin-4. Age (2013) 35:59-67. doi:10.1007/s11357-011-9330-5
35. Roshini P, Weiguo L, Zhi Q, Johnson MA, Fagan SC, Ergul A. Vascularization pattern after ischemic stroke is different in control versus diabetic rats: relevance to stroke recovery. Stroke (2013) 44:2875-83. doi:10.1161/STROKEAHA.113.001660
36. Roemer SF, Parisi JE, Lennon VA, Benarroch EE, Lassmann H, Bruck W, et al. Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis. Brain (2007) 130(5):1194-205. doi:10.1093/brain/awl371
37. Akdemir G, Ratelade J, Asavapanumas N, Verkman AS. Neuroprotective effect of aquaporin-4 deficiency in a mouse model of severe global cerebral ischemia produced by transient 4-vessel occlusion. Neurosci Lett (2014). doi:10.1016/j.neulet.2014.03.073
38. Katada R, Akdemir G, Asavapanumas N, Ratelade J, Zhang H, Verkman AS. Greatly improved survival and neuroprotection in aquaporin-4-knockout mice following global cerebral ischemia. FASEB J (2014) 28(2):705-14. doi:10.1096/fj.13-231274
39. Hatta K, Kishi Y, Wada K, Takeuchi T, Odawara T, Usui C, et al. Preventive effects of ramelteon on delirium a randomized placebo-controlled trial. JAMA Psychiatry (2014) 71(4):397-403. doi:10.1001/jamapsychiatry.2013.3320
40. Bhattacharyaa P, Kumar A, Paulb PS, Patnaikb R. Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia. Life Sci (2014) 100(2):97-109. doi:10.1016/j.lfs.2014.01.085
41. Esposito E, Cuzzocrea S. Antiinflammatory activity of melatonin in central nervous system. Curr Neuropharmacol (2010) 8(3):228-42. doi:10.2174/157015910792246155
42. Frigeri A, Nicchia GP, Svelto M. Aquaporins as targets for drug discovery. Curr Pharm Des (2007) 13(23):2421-7. doi:10.2174/138161207781368738
43. Yool AJ, Brown EA, Flynn GA. Roles for novel pharmacological blockers of aquaporins in the treatment of brain oedema and cancer. Clin Exp Pharmacol Physiol (2010) 37(4):403-9. doi:10.1111/j.1440-1681.2009.05244.x
44. Bhattacharya P, Kumar A, Dileep PR, Yavagal DR. Aquaporin-4 inhibition mediates piroxicam-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rodents. PLoS One (2013) 8(9):e73481. doi:10.1371/journal.pone.0073481
45. Zhang H, Saadoun S, Phuan PW, Lam C, Papadopoulos MC, Bennett JL, et al. Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Ann Neurol (2012) 71(3):314-22. doi:10.1002/ana.22657