Multimodal optical imaging can reveal changes in microcirculation and tissue oxygenation during skin wound healing

Lasers in Surgery and Medicine

Volumn 46, Issue 6, 2014, Pages 470-478

  Wang, Hequn ^a   Shi, Lei ^a   Qin, Jia ^a   Yousefi, Siavash ^a   Li, Yuandong ^a   Wang, Ruikang K ^a  

^a University of Washington   (United States)

Author keywords

laser speckle imaging (LSI); microcirculation; optical coherence tomography (OCT); optical microangiography (OMAG); wound healing

Indexed keywords

HEMOGLOBIN;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; BLOOD FLOW VELOCITY; CAPILLARY; CONTROLLED STUDY; DEOXYGENATION; DUAL WAVELENGTH LASER SPECKLE IMAGING; EAR; FLUORESCENCE IMAGING; HEMODYNAMIC PARAMETERS; IN VIVO STUDY; METABOLISM; MICROANGIOGRAPHY; MICROCIRCULATION; MICROVASCULATURE; MOUSE; MULTIMODAL IMAGING; NONHUMAN; PRIORITY JOURNAL; SKIN INJURY; TISSUE OXYGENATION; WOUND HEALING; ANIMAL; HEMODYNAMICS; INJURIES; PHYSIOLOGY; PROCEDURES; SKIN; THREE DIMENSIONAL IMAGING; VASCULARIZATION;

ANIMALS; BLOOD FLOW VELOCITY; EAR; HEMODYNAMICS; IMAGING, THREE-DIMENSIONAL; MICE; MICROCIRCULATION; NEOVASCULARIZATION, PHYSIOLOGIC; OPTICAL IMAGING; SKIN; WOUND HEALING;

EID: 84904463044     PISSN: 01968092     EISSN: 10969101     Source Type: Journal    
DOI: 10.1002/lsm.22254     Document Type: Article

References (37)

1. Brigham PA, McLoughlin E,. Burn incidence and medical care use in the United States: Estimates, trends, and data sources. J Burn Care Res 1996; 17: 95-107. (Pubitemid 26099431)
2. Branski LK, Gauglitz GG, Herndon DN, Jeschke MG,. A review of gene and stem cell therapy in cutaneous wound healing. Burns 2009; 35: 171-180.
3. Singer AJ, Clark RA,. Cutaneous wound healing. N Engl J Med 1999; 341: 738-746. (Pubitemid 29407375)
4. Hunt TK, editor. Wound healing and wound infection: Theory and surgical practice. New York: Appleton-Century-Crofts: 1980.
5. Clark RA, editor. The molecular and cellular biology of wound repair. New York: Springer; 1996.
6. Bao P, Kodra A, Tomic-Canic M, Golinko MS, Ehrlich HP, Brem H,. The role of vascular endothelial growth factor in wound healing. J Surg Res 1999; 153: 347-358.
7. Clark S, Campbell F, Moore T, Jayson MIV, King TA, Herrick AL,. Laser Doppler imaging-A new technique for quantifying microcirculatory flow in patients with primary Raynaud's phenomenon and systemic sclerosis. Microvasc Res 1999; 57: 284-291. (Pubitemid 29393273)
8. Debbabi H, Bonnin P, Ducluzeau PH, Georges Lefthériotis G, Levy1 BI,. Noninvasive assessment of endothelial function in the skin microcirculation. Am J Hypertens 2010; 23: 541-546.
9. Lockwood GR, Turnball DH, Christopher DA, Foster FS,. Beyond 30 MHz [applications of high-frequency ultrasound imaging]. Eng Med Biol Mag IEEE 1996; 15: 60-71.
10. Anderson H, Price P,. Clinical measurement of blood flow in tumours using positron emission tomography: A review. Nucl Med Commun 2002; 23: 131-138. (Pubitemid 34547900)
11. Helbich TH, Roberts TP, Rollins MD, Shames DM, Turetschek K, Hopf HW, Mühler M, Hunt TK, Brasch RC,. Noninvasive assessment of wound-healing angiogenesis with contrast-enhanced MRI. Acad Radiol 2002; 9: S145-S147. (Pubitemid 34441468)
12. Beard P,. Biomedical photoacoustic imaging. Interface Focus 2011; 1: 602-631.
13. Hu S, Maslov K, Wang LV,. Noninvasive label-free imaging of microhemodynamics by optical-resolution photoacoustic microscopy. Opt Express 2009; 17: 7688-7693.
14. Hu S, Maslov K, Wang LV,. Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed. Opt Lett 2011; 36: 1134-1136.
15. Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA, Fujimoto JG,. Optical coherence tomography. Science 1991; 254: 1178-1181. (Pubitemid 21917444)
16. Wang RK, Jacques SL, Ma Z, Hurst S, Hanson SR, Gruber A,. Three dimensional optical angiography. Opt Express 2007; 15: 4083-4097. (Pubitemid 46557569)
17. An L, Qin J, Wang RK,. Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds. Opt Express 2010; 18: 8220-8228.
18. Wang RK, An L,. Doppler optical micro-angiography for volumetric imaging of vascular perfusion in vivo. Opt Express 2009; 17: 8926-8940.
19. Shi L, Qin J, Reif R, Wang RK,. Wide velocity range Doppler optical microangiography using optimized step-scanning protocol with phase variance mask. J Biomed Opt 2013; 18: 106015.
20. Luo Z, Yuan Z, Pan Y, Du C,. Simultaneous imaging of cortical hemodynamics and blood oxygenation change during cerebral ischemia using dual-wavelength laser speckle contrast imaging. Opt Lett 2009; 34: 1480-1482.
21. Reif R, Qin J, Shi L, Dziennis S, Zhi Z, Nuttall A, Wang RK,. Monitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system. PloS ONE 2012; 7: e52041.
22. Srinivasan VJ, Sakadžic' S, Gorczynska I, Ruvinskaya S, Wu W, Fujimoto JG, Boas DA,. Quantitative cerebral blood flow with optical coherence tomography. Opt Express 2010; 18: 2477-2494.
23. Zhi Z, Yin X, Dziennis S, Wietecha T, Hudkins KL, Alpers CE, Wang RK,. Optical microangiography of retina and choroid and measurement of total retinal blood flow in mice. Biomed Opt Express 2012; 3: 2976-2986.
24. Li J, Chen J, Kirsner R,. Pathophysiology of acute wound healing. Clin Dermatol 2007; 25: 9-18. (Pubitemid 46177460)
25. Luo Q, Jiang C, Li P, Cheng H, Wang Z, Wang Z, Tuchin VV,. Laser speckle imaging of cerebral blood flow. In:, Tuchin VV, editor. Coherent-domain optical methods: Biomedical diagnostics, environmental monitoring and material science. New York, NY: Springer-Verlag; 2012. pp 167-211.
26. Adair TH, Gay WJ, Montani JP,. Growth regulation of the vascular system: Evidence for a metabolic hypothesis. Am J Physiol-Reg I 1990; 259: R393-R404. (Pubitemid 20307558)
27. Knighton DR, Hunt TK, Scheuenstuhl H, Halliday BJ, Werb Z, Banda MJ,. Oxygen tension regulates the expression of angiogenesis factor by macrophages. Science 1983; 221: 1283-1285. (Pubitemid 13001278)
28. Elson DA, Ryan HE, Snow JW, Johnson R, Arbeit JM,. Regular articles-tumor biology-coordinate up-regulation of hypoxia inducible factor (HIF)-1a and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res 2000; 60: 6189-6195.
29. Mace KA, Yu DH, Paydar KZ, Boudreau N, Young DM,. Sustained expression of Hif-1α in the diabetic environment promotes angiogenesis and cutaneous wound repair. Wound Repair Regen 2007; 15: 636-645. (Pubitemid 47493890)
30. Silver IA,. The measurement of oxygen tension in healing tissue. Progr Resp Res 1969; 3: 124-135.
31. Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL,. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000; 157: 411-421. (Pubitemid 30626905)
32. Knighton DR, Silver IA, Hunt TK,. Regulation of wound-healing angiogenesis-effect of oxygen gradients and inspired oxygen concentration. Surgery 1981; 90: 262-270. (Pubitemid 11047238)
33. Frank S, Hübner G, Breier G, Longaker MT, Greenhalgh DG, Werner S,. Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. J Biol Chem 1995; 270: 12607-12613.
34. Stamatas GN, Southall M, Kollias N,. In vivo monitoring of cutaneous edema using spectral imaging in the visible and near infrared. J Invest Dermatol 2006; 126: 1753-1760. (Pubitemid 44086509)
35. Hübner G, Brauchle M, Smola H, Madlener M, Fässlerc R, Werner S,. Differential regulation of pro-inflammatory cytokines during wound healing in normal and glucocorticoid-treated mice. Cytokine 1996; 8: 548-556. (Pubitemid 26294545)
36. Menke NB, Ward KR, Witten TM, Bonchev DG, Diegelmann RF,. Impaired wound healing. Clin Dermatol 2007; 25: 19-25. (Pubitemid 46177472)
37. Broadley KN, Aquino AM, Woodward SC, Buckley-Sturrock A, Sato Y, Rifkin DB, Davidson JM,. Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair. Lab Invest 1989; 61: 571-575. (Pubitemid 20007123)