Anti-asthma effects of synthetic salidroside through regulation of Th1/Th2 balance

Chinese Journal of Natural Medicines

Volumn 12, Issue 7, 2014, Pages 500-504

  Wang, Jing ^a   Jin, Rong Guang ^a   Xiao, Lu ^a   Wang, Qiu Juan ^a   Yan, Tian Hua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Asthma; Synthetic salidroside; Th1 Th2

Indexed keywords

DEXAMETHASONE; GAMMA INTERFERON; INTERLEUKIN 4; MESSENGER RNA; OVALBUMIN; SALIDROSIDE; ANTIASTHMATIC AGENT; GLUCOSIDE; PHENOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EDEMA; FEMALE; HISTOPATHOLOGY; INFLAMMATION; LUNG LAVAGE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; RESPIRATORY TRACT ALLERGY; TH1 TH2 BALANCE; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGY; SYNTHESIS; TH1 CELL; TH2 CELL;

ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; FEMALE; GLUCOSIDES; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; PHENOLS; TH1 CELLS; TH2 CELLS;

EID: 84904431347     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.1016/S1875-5364(14)60078-9     Document Type: Article

References (17)

1. Brightling CE, Symon FA, Birring SS Th2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis [J]. J Allergy Clin Immunol 2002, 110(6):899-905.
2. Nauta AJ, Engels F, Knippels LM, et al. Mechanisms of allergy and asthma [J]. Eur J Pharmacol 2008, 585(2-3):354-360.
3. Epstein MM Targeting memory Th2 cells for the treatment of allergic asthma [J]. Pharmacol Ther 2006, 109(1-2):107-136.
4. Romagnani S Immunologic influences on allergy and the TH1/TH2 balance[J]. J Allergy Clin Immunol 2004, 113(3):395-400.
5. Wilczynski JR Th1/Th2 cytokines balance-yin and yang of reproductive immunology [J]. Eur J Obstet Gynecol Reprod Biol 2005, 122(2):136-143.
6. Packard KA, Khan MM Effects of histamine on Th1/Th2 cytokine balance [J]. Int Immunopharmacol 2003, 3(7):909-920.
7. Wu C, Yang G, Bermudez-Humaran LG, et al. Immunomodulatory effects of IL-12 secreted by Lactococcus lactis on Th1/Th2 balance in ovalbumin (OVA)-induced asthma model mice [J]. Int Immunopharmacol 2006, 6(4):610-615.
8. Liang XQ, Xie P, Zhang Y, et al. Effects of salidroside on myocardial ischemia/reperfusion injury in rats [J]. Chin J Nat Med 2010, 8(2):127-131.
9. Guan S, Feng HH, Song BC, et al. Salidroside attenuates LPS-induced pro-inflammatory cytokine responses and improves survival in murine endotoxemia [J]. Int Immunopharmacol 2011, 11(12):2194-2199.
10. +-induced apoptosis via activation of the PI3K/Akt pathway [J]. Food Chem Toxicol 2012, 50(8):2591-2597.
11. Guan S, He J, Guo W, et al. Adjuvant effects of salidroside from Rhodiola rosea L. on the immune responses to ovalbumin in mice [J]. Immunopharmacol Immunotoxicol 2011, 33(4):738-743.
12. Park HJ, Lee CM, Jung ID, et al. Quercetin regulates Th1/Th2 balance in a murine model of asthma [J]. Inter Immunopharmacol 2009, 9(3):261-267.
13. Yuk JE, Lee MY, Kwon OK, et al. Effects of astilbic acid on airway hyper-responsiveness and inflammation in a mouse model of allergic asthma [J]. Int Immunopharmacol 2011, 11(2):266-273.
14. Chu X, Wei M, Yang X, et al. Effects of an anthraquinone derivative from Rheum officinale Baill, emodin, on airway responses in a murine model of asthma [J]. Food Chem Toxicol 2012, 50(7):2368-2375.
15. Wenzel SE Asthma: defining of the persistent adult phenotypes [J]. Lancet 2006, 368(9537):804-813.
16. Elsner J, Kapp A Regulation and modulation of eosinophil effector functions [J]. Allergy 1999, 54(1):15-26.
17. Elias JA, Lee CG, Zheng T New insights into the pathogenesis of asthma [J]. J Clin Invest 2003, 111(3):291-297.