Activating human genes with zinc finger proteins, transcription activator-like effectors and CRISPR/Cas9 for gene therapy and regenerative medicine

Expert Opinion on Therapeutic Targets

Volumn 18, Issue 8, 2014, Pages 835-839

  Gersbach, Charles A ^a,b,c   Perez Pinera, Pablo ^a  

^a Duke University   (United States)

^b DUKE UNIVERSITY   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cas9; CRISPR; Gene editing; Gene regulation; Gene therapy; Genetic reprogramming; Protein engineering; Transcription activator like effector; Transcription factor; Zinc finger

Indexed keywords

CRISPR ASSOCIATED PROTEIN; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; TRANSACTIVATOR PROTEIN;

CRISPR CAS SYSTEM; GENE ACTIVATION; GENE CONTROL; GENE THERAPY; GENETIC DISORDER; HUMAN; NONHUMAN; PHASE 2 CLINICAL TRIAL (TOPIC); REGENERATIVE MEDICINE; REVIEW; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; GENE EXPRESSION REGULATION; GENETICS; NUCLEOTIDE SEQUENCE; PROCEDURES;

BASE SEQUENCE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; GENE EXPRESSION REGULATION; GENETIC THERAPY; HUMANS; REGENERATIVE MEDICINE; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 84904419786     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2014.913572     Document Type: Review

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