Synthesis and imaging validation of [18F]MDL100907 enabled by Ni-mediated fluorination

ACS Chemical Neuroscience

Volumn 5, Issue 7, 2014, Pages 611-615

  Ren, Hong ^a,b   Wey, Hsiao Ying ^a   Strebl, Martin ^b   Neelamegam, Ramesh ^a   Ritter, Tobias ^b   Hooker, Jacob M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

MDL100907; nickel mediated; PET imaging; serotonin receptors

Indexed keywords

RADIOPHARMACEUTICAL AGENT; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG; VOLINANSERIN C 11; VOLINANSERIN F 18; CARBON; FLUORINE; FLUOROBENZENE; PIPERIDINE DERIVATIVE; SEROTONIN 2 ANTAGONIST; VOLINANSERIN;

ARTICLE; BRAIN; DRUG SYNTHESIS; DRUG UPTAKE; FLUORINATION; FRONTAL CORTEX; NEUROSCIENCE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SUPPLEMENTARY MOTOR AREA; ANIMAL; CHEMISTRY; DIAGNOSTIC USE; HALOGENATION; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; PAPIO ANUBIS; SCINTISCANNING; SYNTHESIS; TIME; VALIDATION STUDY;

ANIMALS; BRAIN; CARBON RADIOISOTOPES; FLUORINE RADIOISOTOPES; FLUOROBENZENES; HALOGENATION; MAGNETIC RESONANCE IMAGING; PAPIO ANUBIS; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS; TIME FACTORS;

EID: 84904417095     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn500078e     Document Type: Article

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