Histologic Changes in Liver Tissue From Patients With Chronic Hepatitis B and Minimal Increases in Levels of Alanine Aminotransferase: A Meta-analysis and Systematic Review

Clinical Gastroenterology and Hepatology

Volumn 12, Issue 8, 2014, Pages 1262-1266

  Nguyen, Long H ^a   Chao, David ^b   Lim, Joseph K ^c   Ayoub, Walid ^d   Nguyen, Mindie H ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Cedar Sinai Medical Center   (United States)

Author keywords

Cirrhosis; HBeAg; HBV; Patient Management

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIVIRUS AGENT; HEPATITIS B(E) ANTIGEN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIVIRAL THERAPY; ARTICLE; CASE REPORT; EVALUATION AND FOLLOW UP; HEPATITIS B; HISTOLOGY; HUMAN; INFORMATION RETRIEVAL; LIVER FIBROSIS; MEDLINE; META ANALYSIS (TOPIC); SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW; BLOOD; CYTOCHEMISTRY; LIVER CIRRHOSIS; META ANALYSIS; PATHOLOGY; PATHOPHYSIOLOGY; STATISTICS; BODY MASS; DISEASE COURSE; FOLLOW UP; PREVALENCE; RISK FACTOR;

ALANINE TRANSAMINASE; HEPATITIS B, CHRONIC; HISTOCYTOCHEMISTRY; HUMANS; LIVER CIRRHOSIS; STATISTICS AS TOPIC;

EID: 84904391702     PISSN: 15423565     EISSN: 15427714     Source Type: Journal    
DOI: 10.1016/j.cgh.2013.11.038     Document Type: Article

References (19)

1. McQuillan G.M., Coleman P.J., Kruszon-Moran D., et al. Prevalence of hepatitis B virus infection in the United States: the National Health and Nutrition Examination Surveys, 1976 through 1994. Am J Public Health 1999, 89:14-18.
2. USA quick facts from the US Census Bureau [database on the Internet]. 2008. Available at: Accessed January 2,2008. http://quickfacts.census.gov/qfd/states/00000.html.
3. McMahon B.J. Epidemiology and natural history of hepatitis B. Semin Liver Dis 2005, 25(Suppl 1):3-8.
4. Lok A.S., McMahon B.J. Chronic hepatitis B. Hepatology 2007, 45:507-539.
5. Lok A.S., McMahon B.J. Chronic hepatitis B: update 2009. Hepatology 2009, 50:661-662.
6. Kim W.R., Flamm S.L., Di Bisceglie A.M., et al. Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease. Hepatology 2008, 47:1363-1370.
7. Prati D., Taioli E., Zanella A., et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002, 137:1-10.
8. Whiting P., Rutjes A.W., Reitsma J.B., et al. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol 2003, 3:25.
9. Cooper H. The handbook of research synthesis. 1st ed. Hedges LV, ed. New York: Russell Sage Foundation, 1994:573.
10. Alallam A., Adeyi O., Fung S. Significant liver fibrosis can be found among chronic hepatitis B patients with minimally elevated ALT. Hepatology 2010, 52(Suppl S1):998A.
11. Alam S., Ahmad N., Mustafa G., et al. Evaluation of normal or minimally elevated alanine transaminase, age and DNA level in predicting liver histological changes in chronic hepatitis B. Liver Int 2011, 31:824-830.
12. Chen E.Q., Huang F.J., He L.L., et al. Histological changes in Chinese chronic hepatitis B patients with ALT lower than two times upper limits of normal. Dig Dis Sci 2010, 55:432-437.
13. Croagh C.M., Bell S.J., Slavin J., et al. Increasing hepatitis B viral load is associated with risk of significant liver fibrosis in HBeAg-negative but not HBeAg-positive chronic hepatitis B. Liver Int 2010, 30:1115-1122.
14. Lai M., Hyatt B.J., Nasser I., et al. The clinical significance of persistently normal ALT in chronic hepatitis B infection. JHepatol 2007, 47:760-767.
15. Lesmana C.R., Gani R.A., Hasan I., et al. Significant hepatic histopathology in chronic hepatitis B patients with serum ALT less than twice ULN and high HBV-DNA levels in Indonesia. JDig Dis 2011, 12:476-480.
16. Molina-Perez E., Castroagudin J.F., Aguilera-Guirao A., et al. Viral and host factors related with histopathologic activity in patients with chronic hepatitis B and moderate or intermittently elevated alanine aminotransferase levels. Rev Esp Enferm Dig 2010, 102:519-525.
17. Park J.Y., Park Y.N., Kim D.Y., et al. High prevalence of significant histology in asymptomatic chronic hepatitis B patients with genotype C and high serum HBV DNA levels. JViral Hepat 2008, 15:615-621.
18. Tsang P.S., Trinh H., Garcia R.T., et al. Significant prevalence of histologic disease in patients with chronic hepatitis B and mildly elevated serum alanine aminotransferase levels. Clin Gastroenterol Hepatol 2008, 6:569-574.
19. Orwin R.G. A fail-safe N for effect size in meta-analysis. J Educ Stat 1983, 8:157-159.