Significant hepatic histopathology in chronic hepatitis B patients with serum ALT less than twice ULN and high HBV-DNA levels in Indonesia

Journal of Digestive Diseases

Volumn 12, Issue 6, 2011, Pages 476-480

  Lesmana, C Rinaldi A ^a,b   Gani, Rino A ^a   Hasan, Irsan ^a   Simadibrata, Marcellus ^a   Sulaiman, Andri S ^a   Pakasi, Levina S ^b   Budihusodo, Unggul ^a   Krisnuhoni, Ening ^c   Lesmana, Laurentius A ^a,b  

^a CIPTO MANGUNKUSUMO HOSPITAL   (Indonesia)

^b Medistra Hospital   (Indonesia)

^c UNIVERSITY OF INDONESIA   (Indonesia)

Author keywords

Chronic hepatitis B; Normal alanine aminotransferase; Significant liver histopathology

Indexed keywords

ALANINE AMINOTRANSFERASE; HEPATITIS B(E) ANTIGEN;

ADOLESCENT; ADULT; AGED; ARTICLE; FEMALE; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HISTOPATHOLOGY; HUMAN; INDONESIA; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY;

ADOLESCENT; ADULT; AGED; ALANINE TRANSAMINASE; BIOPSY; DNA, VIRAL; FEMALE; GENOTYPE; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INCIDENCE; INDONESIA; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 82355191992     PISSN: 17512972     EISSN: 17512980     Source Type: Journal    
DOI: 10.1111/j.1751-2980.2011.00540.x     Document Type: Article

References (15)

1. Liaw YF, Leung N, Kao JH etal. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update. Hepatol Int 2008; 2: 263-83.
2. Dragosics B, Ferenci P, Hitchman E, Denk H. Long-term follow-up study of asymptomatic HBsAg-positive voluntary blood donors in Austria: a clinical and histological evaluation of 242 cases. Hepatology 1987; 7: 302-6.
3. De Franchis R, D'Arminio A, Vecchi M etal. Chronic asymptomatic HBsAg carriers: histologic abnormalities and diagnostic and prognostic value of serologic markers of the HBV. Gastroenterology 1980; 79: 521-7.
4. Lai M, Hyatt BJ, Nasser I, Curry M, Afdhal NH. The clinical significance of persistently normal ALT in chronic hepatitis B infection. J Hepatol 2007; 47: 760-7.
5. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. The French METAVIR Cooperation Study Group. Hepatology 1994; 20: 15-20.
6. Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR cooperative study group. Hepatology 1996; 24: 289-93.
7. Sarin SK, Kumar M. Should chronic HBV infected patients with normal ALT treated: debated. Hepatol Int 2008; 2: 179-84.
8. Nguyen MH, Garcia RT, Trinh HN etal. Histological disease in Asian-Americans with chronic hepatitis B, high hepatitis B virus DNA, and normal alanine aminotransferase levels. Am J Gastroenterol 2009; 104: 2206-13.
9. Iloejo UH, Yang HI, Su J, Jen CL, You SL, Chen CJ. Predicting liver cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006; 130: 678-86.
10. Fujiwara A, Sakaguchi K, Fujioka S etal. Fibrosis progression rates between chronic hepatitis B and C patients with elevated alanine aminotransferase levels. J Gastroenterol 2008; 43: 484-91.
11. Park JY, Park YN, Kim DY etal. High prevalence of significant histology in asymptomatic chronic hepatitis B patients with genotype C and high serum HBV DNA levels. J Viral Hepat 2008; 15: 615-21.
12. Tsang PS, Trinh H, Garcia RT etal. Significant prevalence of histologic disease in patients with chronic hepatitis B and mildly elevated serum alanine aminotransferase levels. Clin Gastroenterol Hepatol 2008; 6: 569-74.
13. Chen EQ, Huang FJ, He LL etal. Histological changes in Chinese chronic hepatitis B patients with ALT lower than two times upper limits of normal. Dig Dis Sci 2009; 2010; 55:432-7.
14. Shao J, Wei L, Wang H etal. Relationship between hepatitis B virus DNA levels and liver histology in patients with chronic hepatitis B. World J Gastroenterol 2007; 13: 2104-7.
15. Lesmana LA, Leung NWY, Mahachai V etal. Hepatitis B: overview of the burden of disease in the Asia-Pacific region. Liver Int 2006; 26: 3-10.