Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: Evidence of disrupted noradrenergic signaling in anxiety-related alcohol use

Brain and Behavior

Volumn 4, Issue 4, 2014, Pages 468-483

  Skelly, Mary J ^a   Weiner, Jeff L ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Duloxetine; Osmotic minipump; Plus maze; Prazosin; Propranolol; Stress

Indexed keywords

DULOXETINE; PRAZOSIN; PROPRANOLOL; ADRENERGIC RECEPTOR AFFECTING AGENT; ALCOHOL; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ANXIOLYTIC AGENT; THIOPHENE DERIVATIVE;

ADULT; ALCOHOLISM; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; ELEVATED PLUS MAZE TEST; LOCOMOTION; MALE; NONHUMAN; OPEN FIELD TEST; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; ANIMAL; ANXIETY; DRUG EFFECTS; DRUG SELF ADMINISTRATION; DRUG THERAPY; LONG EVANS RAT;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ADRENERGIC UPTAKE INHIBITORS; ALCOHOL DRINKING; ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; BEHAVIOR, ANIMAL; ETHANOL; MALE; PRAZOSIN; RATS; RATS, LONG-EVANS; SELF ADMINISTRATION; THIOPHENES;

EID: 84904385660     PISSN: None     EISSN: 21623279     Source Type: Journal    
DOI: 10.1002/brb3.230     Document Type: Article

References (66)

1. Adinoff, B., K. Junghanns, F. Kiefer, and S. Krishnan-Sarin. 2005. Suppression of the HPA axis stress-response: implications for relapse. Alcohol. Clin. Exp. Res. 29:1351-1355.
2. Amit, Z., Z. W. Brown, D. E. Levitan, and S. O. Ogren. 1977. Noradrenergic mediation of the positive reinforcing properties of ethanol: I. Suppression of ethanol consumption in laboratory rats following dopamine-beta-hydroxylase inhibition. Arch. Int. Pharmacodyn. Ther. 230:65-75.
3. Aston-Jones, G., and G. C. Harris. 2004. Brain substrates for increased drug seeking during protracted withdrawal. Neuropharmacology 47(Suppl. 1):167-179.
4. Aston-Jones, G., S. L. Foote, and F. E. Bloom. 1982. Low doses of ethanol disrupt sensory responses of brain noradrenergic neurones. Nature 296:857-860.
5. Bailly, D., D. Servant, N. Blandin, R. Beuscart, and P. J. Parquet. 1992. Effects of beta-blocking drugs in alcohol withdrawal: a double-blind comparative study with propranolol and diazepam. Biomed. Pharmacother. 46:419-424.
6. Banerjee, S. P., V. K. Sharma, and J. M. Khanna. 1978. Alterations in beta-adrenergic receptor binding during ethanol withdrawal. Nature 276:407-409.
7. Becker, H. C. 2012. Effects of alcohol dependence and withdrawal on stress responsiveness and alcohol consumption. Alcohol Res. 34:448-458.
8. Brown, S. L., D. S. Charney, S. W. Woods, G. R. Heninger, and J. Tallman. 1988. Lymphocyte beta-adrenergic receptor binding in panic disorder. Psychopharmacology 94:24-28.
9. Carlsson, C., and T. Johansson. 1971. The psychological effects of propranolol in the abstinence phase of chronic alcoholics. Br. J. Psychiatry 119:605-606.
10. Chappell, A. M., E. Carter, B. A. McCool, and J. L. Weiner. 2013. Adolescent rearing conditions influence the relationship between initial anxiety-like behavior and ethanol drinking in male Long Evans rats. Alcohol. Clin. Exp. Res. 37(Suppl. 1):E394-E403.
11. Corcoran, M. E., J. Lewis, and H. C. Fibiger. 1983. Forebrain noradrenaline and oral self-administration of ethanol by rats. Behav. Brain Res. 8:1-21.
12. Davis, W. M., S. G. Smith, and T. E. Werner. 1978. Noradrenergic role in the self-administration of ethanol. Pharmacol. Biochem. Behav. 9:369-374.
13. Delfs, J. M., Y. Zhu, J. P. Druhan, and G. Aston-Jones. 2000. Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion. Nature 403:430-434.
14. Dimsdale, J. E., P. Mills, T. Patterson, M. Ziegler, and E. Dillon. 1994. Effects of chronic stress on beta-adrenergic receptors in the homeless. Psychosom. Med. 56:290-295.
15. File, S. E., P. S. Mabbutt, and P. K. Hitchcott. 1990. Characterisation of the phenomenon of "one-trial tolerance" to the anxiolytic effect of chlordiazepoxide in the elevated plus-maze. Psychopharmacology 102:98-101.
16. Fox, H. C., G. M. Anderson, K. Tuit, J. Hansen, A. Kimmerling, K. M. Siedlarz, et al. 2012. Prazosin effects on stress- and cue-induced craving and stress response in alcohol-dependent individuals: preliminary findings. Alcohol. Clin. Exp. Res. 36:351-360.
17. Froehlich, J. C., B. J. Hausauer, D. L. Federoff, S. M. Fischer, and D. D. Rasmussen. 2013a. Prazosin reduces alcohol drinking throughout prolonged treatment and blocks the initiation of drinking in rats selectively bred for high alcohol intake. Alcohol. Clin. Exp. Res. 37:1552-1560.
18. Froehlich, J. C., B. J. Hausauer, and D. D. Rasmussen. 2013b. Combining naltrexone and prazosin in a single oral medication decreases alcohol drinking more effectively than does either drug alone. Alcohol. Clin. Exp. Res. 37:1763-1770.
19. Gilpin, N. W., and G. F. Koob. 2010. Effects of beta-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats. Psychopharmacology 212:431-439.
20. Grant, B. F., F. S. Stinson, D. A. Dawson, S. P. Chou, M. C. Dufour, W. Compton, et al. 2004. Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch. Gen. Psychiatry 61:807-816.
21. Gurguis, G. N., J. Turkka, J. Karanian, and M. Linnoila. 1998. The combined effects of chronic ethanol/desipramine treatment on beta-adrenoceptor density and coupling efficiency in rat brain. Eur. J. Pharmacol. 363:241-251.
22. Gurguis, G. N., J. Turkka, M. Laruelle, J. Kleinman, and M. Linnoila. 1999. Coupling efficiency of brain beta-adrenergic receptors to Gs protein in suicide, alcoholism and control subjects. Psychopharmacology 145:31-38.
23. Hawley, R. J., C. B. Nemeroff, G. Bissette, A. Guidotti, R. Rawlings, and M. Linnoila. 1994. Neurochemical correlates of sympathetic activation during severe alcohol withdrawal. Alcohol. Clin. Exp. Res. 18:1312-1316.
24. Ji, D., N. W. Gilpin, H. N. Richardson, C. L. Rivier, and G. F. Koob. 2008. Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats. Behav. Pharmacol. 19:1-12.
25. Kang, E. H., and B. H. Yu. 2005. Anxiety and beta-adrenergic receptor function in a normal population. Prog. Neuropsychopharmacol. Biol. Psychiatry 29:733-737.
26. Khantzian, E. J. 1985. The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. Am. J. Psychiatry 142:1259-1264.
27. Kim, S. W., I. S. Shin, J. M. Kim, H. C. Kang, J. U. Mun, S. J. Yang, et al. 2006. Mirtazapine for severe gastroparesis unresponsive to conventional prokinetic treatment. Psychosomatics 47:440-442.
28. Koob, G. F. 2013. Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Curr. Top Behav. Neurosci. 13:3-30.
29. Le, A. D., S. Harding, W. Juzytsch, D. Funk, and Y. Shaham. 2005. Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats. Psychopharmacology 179:366-373.
30. Liappas, J., T. Paparrigopoulos, E. Tzavellas, and A. Rabavilas. 2005. Mirtazapine and venlafaxine in the management of collateral psychopathology during alcohol detoxification. Prog. Neuropsychopharmacol. Biol. Psychiatry 29:55-60.
31. Mason, S. T., M. E. Corcoran, and H. C. Fibiger. 1979. Noradrenaline and ethanol intake in the rat. Neurosci. Lett. 12:137-142.
32. McCool, B. A., and A. Chappell. 2007. Strychnine and taurine modulation of amygdala-associated anxiety-like behavior is 'state' dependent. Behav. Brain Res. 178:70-81.
33. Patkar, A. A., R. Gopalakrishnan, P. C. Naik, H. W. Murray, M. J. Vergare, and C. A. Marsden. 2003. Changes in plasma noradrenaline and serotonin levels and craving during alcohol withdrawal. Alcohol Alcohol. 38:224-231.
34. Patkar, A. A., C. A. Marsden, P. C. Naik, D. A. Kendall, R. Gopalakrishnan, M. J. Vergare, et al. 2004. Differences in peripheral noradrenergic function among actively drinking and abstinent alcohol-dependent individuals. Am. J. Addict. 13:225-235.
35. Pavcovich, L. A., L. M. Cancela, M. Volosin, V. A. Molina, and O. A. Ramirez. 1990. Chronic stress-induced changes in locus coeruleus neuronal activity. Brain Res. Bull. 24:293-296.
36. Petrakis, I. L., E. Ralevski, N. Desai, L. Trevisan, R. Gueorguieva, B. Rounsaville, et al. 2012. Noradrenergic vs serotonergic antidepressant with or without naltrexone for veterans with PTSD and comorbid alcohol dependence. Neuropsychopharmacology 37:996-1004.
37. Prut, L., and C. Belzung. 2003. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur. J. Pharmacol. 463:3-33.
38. Rasmussen, D. D., C. W. Wilkinson, and M. A. Raskind. 2006. Chronic daily ethanol and withdrawal: 6. Effects on rat sympathoadrenal activity during "abstinence". Alcohol 38:173-177.
39. Rasmussen, D. D., L. L. Alexander, M. A. Raskind, and J. C. Froehlich. 2009. The alpha1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats. Alcohol. Clin. Exp. Res. 33:264-272.
40. Ressler, K. J., and C. B. Nemeroff. 2001. Role of norepinephrine in the pathophysiology of neuropsychiatric disorders. CNS Spectr. 6:663-670.
41. Rimondini, R., C. Arlinde, W. Sommer, and M. Heilig. 2002. Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. FASEB J. 16:27-35.
42. Saglam, E., I. T. Uzbay, H. Kayir, T. Celik, and M. Beyazyurek. 2004. Effects of venlafaxine on ethanol withdrawal syndrome in rats. Fundam. Clin. Pharmacol. 18:693-698.
43. Santucci, A. C., C. Cortes, A. Bettica, and F. Cortes. 2008. Chronic ethanol consumption in rats produces residual increases in anxiety 4 months after withdrawal. Behav. Brain Res. 188:24-31.
44. Sayette, M. A. 1999. Does drinking reduce stress? Alcohol Res. Health 23:250-255.
45. Schneider, P., Y. J. Ho, R. Spanagel, and C. R. Pawlak. 2011. A novel elevated plus-maze procedure to avoid the one-trial tolerance problem. Front. Behav. Neurosci. 5:43.
46. Sellers, E. M., N. C. Degani, D. H. Zilm, and S. M. Macleod. 1976. Letter: propranolol-decreased noradrenaline excretion and alcohol withdrawal. Lancet 1:94-95.
47. Sellers, E. M., D. H. Zilm, and N. C. Degani. 1977. Comparative efficacy of propranolol and chlordiazepoxide in alcohol withdrawal. J. Stud. Alcohol 38:2096-2108.
48. Silberman, Y., O. J. Ariwodola, A. M. Chappell, J. T. Yorgason, and J. L. Weiner. 2010. Lateral paracapsular GABAergic synapses in the basolateral amygdala contribute to the anxiolytic effects of beta 3 adrenoceptor activation. Neuropsychopharmacology 35:1886-1896.
49. Simms, J. A., P. Steensland, B. Medina, K. E. Abernathy, L. J. Chandler, R. Wise, et al. 2008. Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats. Alcohol. Clin. Exp. Res. 32:1816-1823.
50. Simon O'Brien, E., R. Legastelois, H. Houchi, C. Vilpoux, S. Alaux-Cantin, O. Pierrefiche, et al. 2011. Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats. Neuropsychopharmacology 36:1518-1530.
51. Simpson, T. L., A. J. Saxon, C. W. Meredith, C. A. Malte, B. McBride, L. C. Ferguson, et al. 2009. A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence. Alcohol. Clin. Exp. Res. 33:255-263.
52. Sinclair, J. D., and T. K. Li. 1989. Long and short alcohol deprivation: effects on AA and P alcohol-preferring rats. Alcohol 6:505-509.
53. Sinha, R., H. C. Fox, K. I. Hong, J. Hansen, K. Tuit, and M. J. Kreek. 2011. Effects of adrenal sensitivity, stress- and cue-induced craving, and anxiety on subsequent alcohol relapse and treatment outcomes. Arch. Gen. Psychiatry 68:942-952.
54. Skelly, M. J., A. M. Chappell, E. Carter, and J. L. Weiner. 2012. Social isolation disrupts extinction of fear learning and enhances adrenoceptor antagonist-mediated inhibition of ethanol drinking in Long Evans Rats. [abstract]. Alcohol. Clin. Exp. Res. 36(Suppl. 1):115A.
55. Sloan, T. B., J. D. Roache, and B. A. Johnson. 2003. The role of anxiety in predicting drinking behaviour. Alcohol Alcohol. 38:360-363.
56. Spanagel, R., A. Montkowski, K. Allingham, T. Stohr, M. Shoaib, F. Holsboer, et al. 1995. Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats. Psychopharmacology 122:369-373.
57. Valdez, G. R., A. J. Roberts, K. Chan, H. Davis, M. Brennan, E. P. Zorrilla, et al. 2002. Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor. Alcohol. Clin. Exp. Res. 26:1494-1501.
58. Verplaetse, T. L., D. D. Rasmussen, J. C. Froehlich, and C. L. Czachowski. 2012. Effects of prazosin, an alpha1-adrenergic receptor antagonist, on the seeking and intake of alcohol and sucrose in alcohol-preferring (P) rats. Alcohol. Clin. Exp. Res. 36:881-886.
59. Walker, B. M., D. D. Rasmussen, M. A. Raskind, and G. F. Koob. 2008. alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol. Alcohol 42:91-97.
60. West, C. H., J. C. Ritchie, K. A. Boss-Williams, and J. M. Weiss. 2009. Antidepressant drugs with differing pharmacological actions decrease activity of locus coeruleus neurons. Int. J. Neuropsychopharmacol. 12:627-641.
61. Willinger, U., E. Lenzinger, K. Hornik, G. Fischer, G. Schonbeck, H. N. Aschauer, et al. 2002. Anxiety as a predictor of relapse in detoxified alcohol-dependent patients. Alcohol Alcohol. 37:609-612.
62. Wise, R. A. 1973. Voluntary ethanol intake in rats following exposure to ethanol on various schedules. Psychopharmacologia 29:203-210.
63. Yamamoto, K., T. Shinba, and M. Yoshii. 2014. Psychiatric symptoms of noradrenergic dysfunction: a pathophysiological view. Psychiatry Clin. Neurosci. 68:1-20.
64. Yoon, S. J., C. U. Pae, D. J. Kim, K. Namkoong, E. Lee, D. Y. Oh, et al. 2006. Mirtazapine for patients with alcohol dependence and comorbid depressive disorders: a multicentre, open label study. Prog. Neuropsychopharmacol. Biol. Psychiatry 30:1196-1201.
65. Yorgason, J. T., R. A. Espana, J. K. Konstantopoulos, J. L. Weiner, and S. R. Jones. 2013. Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats. Eur. J. Neurosci. 37:1022-1031.
66. Zilm, D. H., E. M. Sellers, S. M. MacLeod, and N. Degani. 1975. Letter: propranolol effect on tremor in alcoholic withdrawal. Ann. Intern. Med. 83:234-236.