Effects of Prazosin, an α1-Adrenergic Receptor Antagonist, on the Seeking and Intake of Alcohol and Sucrose in Alcohol-Preferring (P) Rats

Alcoholism: Clinical and Experimental Research

Volumn 36, Issue 5, 2012, Pages 881-886

  Verplaetse, Terril L ^a   Rasmussen, Dennis D ^b   Froehlich, Janice C ^a   Czachowski, Cristine L ^a  

^a INDIANA UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Alcohol; Noradrenergic; P Rats; Prazosin; Sipper Tube

Indexed keywords

PRAZOSIN;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL SEEKING BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; DRUG SELF ADMINISTRATION; LATENT PERIOD; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUGAR INTAKE; TREATMENT RESPONSE;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ALCOHOL DRINKING; ANIMALS; APPETITIVE BEHAVIOR; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CONSUMMATORY BEHAVIOR; ETHANOL; MALE; PRAZOSIN; RATS; SUCROSE; SWEETENING AGENTS;

ANIMALIA; RATTUS;

EID: 84860485931     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2011.01653.x     Document Type: Article

References (24)

1. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders. 4th ed. American Psychiatric Association, Washington DC.
2. Brady KT, Killeen TK, Brewerton T, Lucerini S (2000) Comorbidity of psychiatric disorders and posttraumatic stress disorder. J Clin Psychiatry 61(Suppl 7):22-32.
3. Bruijnzeel AW, Bishnoi M, van Tuijl IA, Keijzers KFM, Yavarovich KR, Pasek TM, Ford J, Alexander JC, Yamada H (2010) Effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats. Psychopharmacology 212:485-499.
4. Constantine JW, McShane WK, Scriabine A, Hess HJ (1975) Analysis of the hypotensive action of prazosin. Postgrad Med Spec No: 18-35.
5. Czachowski CL, Chappell AM, Samson HH (2001a) Effects of raclopride in the nucleus accumbens on ethanol seeking and consumption. Alcohol Clin Exp Res 25:1431-1440.
6. Czachowski CL, Legg BH, Samson HH (2001b) Effects of acamprosate on ethanol-seeking and self-administration in the rat. Alcohol Clin Exp Res 25:344-350.
7. Czachowski CL, Santini LA, Legg BH, Samson HH (2002) Separate measures of ethanol seeking and drinking in the rat: effects of remoxipride. Alcohol 28:39-46.
8. Davis WM, Smith SG, Werner TE (1978) Noradrenergic role in the self-administration of ethanol. Pharmacol Biochem Behav 9:369-374.
9. Forget B, Wertheim C, Mascia P, Pushparaj A, Goldberg SR, Le Foll B (2010) Noradrenergic alpha(1) receptors as a novel target for the treatment of nicotine addiction. Neuropsychopharmacology 35:1751-1760.
10. Froehlich JC (2010) What aspects of human alcohol use disorders can be modeled using selectively bred rat lines? Subst Use Misuse 45:1727-1741.
11. Garbutt JC, West SL, Carey TS, Lohr KN, Crews FT (1999) Pharmacological treatment of alcohol dependence: a review of the evidence. Journal of the American Medical Association 281:1318-1325.
12. Greenwell TN, Walker BM, Cottone P, Zorrilla EP, Koob GF (2009) The alpha(1) adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration. Pharmacol Biochem Behav 91:295-302.
13. Kranzler HR, Van Kirk J (2001) Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis. Alcohol Clin Exp Res 25:1335-1341.
14. Le AD, Funk D, Juzytsch W, Coen K, Navarre BM, Cifani C, Shaham Y (in press) Effect of prazosin and guanfacine on stress-induced reinstatement of alcohol and food seeking in rats. Psychopharmacology doi: [Epub ahead of print].
15. Li TK, Lumeng L, McBride WJ, Murphy JM (1987) Rodent lines selected for factors affecting alcohol consumption. Alcohol Alcohol Suppl 1:91-96.
16. Menkes DB, Baraban JM, Aghajanian GK (1981) Prazosin selectively antagonizes neuronal responses mediated by alpha-1-adrenoceptors in brain. Naunyn Schmiedebergs Arch Pharmacol 317:273-275.
17. Murphy JM, Stewart RB, Bell RL, Badia-Elder NE, Carr LG, McBride WJ, Lumeng L, Li TK (2002) Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference. Behav Genet 32:363-388.
18. Raskind MA, Peskind ER, Kanter ED, Petrie EC, Radant A, Thompson CE, Dobie DJ, Hoff D, Rein RJ, Straits-Troster K, Thomas RG, McFall MM (2003) Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study. Am J Psychiatry 160:371-373.
19. Rasmussen DD, Alexander LL, Raskind MA, Froehlich JC (2009) The alpha(1)-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats. Alcohol Clin Exp Res 33:264-272.
20. Rasmussen DD, Mitton DR, Green J, Puchalski S (2001) Chronic daily ethanol and withdrawal: 2. Behavioral changes during prolonged abstinence. Alcohol Clin Exp Res 25:999-1005.
21. Rasmussen DD, Wilkinson CW, Raskind MA (2006) Chronic daily ethanol and withdrawal: 6. Effects on rat sympathoadrenal activity during "abstinence." Alcohol 38:173-177.
22. Samson HH (1986) Initiation of ethanol reinforcement using a sucrose-substitution procedure in food-sated and water-sated rats. Alcohol Clin Exp Res 10:436-442.
23. Simpson TL, Saxon AJ, Meredith CW, Malte CA, McBride B, Ferguson LC, Gross CA, Hart KL, Raskind M (2009) A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence. Alcohol Clin Exp Res 33:255-263.
24. Walker BM, Rasmussen DD, Raskind MA, Koob GF (2008) Alpha(1)-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol. Alcohol 42:91-97.