The WRAIR projectile concussive impact model of mild traumatic brain injury: Re-design, testing and preclinical validation

Annals of Biomedical Engineering

Volumn 42, Issue 8, 2014, Pages 1618-1630

  Leung, Lai Yee ^a   Larimore, Zachary ^b   Holmes, Larry ^b   Cartagena, Casandra ^a   Mountney, Andrea ^a   Deng Bryant, Ying ^a   Schmid, Kara ^a   Shear, Deborah ^a   Tortella, Frank ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b U S ARMY RESEARCH LABORATORY   (United States)

Author keywords

Concussion; Gait; Head kinematics; Helmet; Impact energy; Mild TBI; Projectile

Indexed keywords

ACCIDENT PREVENTION; BRAIN; CHEMICAL ACTIVATION; KINEMATICS; LOAD TESTING; PROJECTILES; RATS;

CONCUSSION; GAIT; HELMET; IMPACT ENERGY; MILD TBI;

STEEL TESTING;

CARBON; CARBON FIBER; GLASS FIBER; STEEL; AMYLOID BETA PROTEIN; GLASS;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; AXONAL INJURY; BRAIN CONCUSSION; CELL ACTIVATION; CONTROLLED STUDY; DISEASE MODEL; GAIT DISORDER; HELMET; HIPPOCAMPUS; KINEMATICS; MALE; MATERIALS TESTING; NONHUMAN; PARIETAL LOBE; PILOT STUDY; PRIORITY JOURNAL; PROJECTILE CONCUSSIVE IMPACT MODEL; RAT; STUDY DESIGN; TEMPORAL LOBE; TRAUMATIC BRAIN INJURY; VALIDATION STUDY; YOUNG MODULUS; ANIMAL; BIOMECHANICS; BRAIN; BRAIN INJURY; GAIT; METABOLISM; NERVE FIBER; PATHOLOGY; PATHOPHYSIOLOGY; REPRODUCIBILITY; SPRAGUE DAWLEY RAT;

AMYLOID BETA-PEPTIDES; ANIMALS; AXONS; BIOMECHANICAL PHENOMENA; BRAIN; BRAIN CONCUSSION; BRAIN INJURIES; CARBON; DISEASE MODELS, ANIMAL; GAIT; GLASS; HEAD PROTECTIVE DEVICES; MALE; MATERIALS TESTING; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS;

EID: 84904381673     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-014-1014-8     Document Type: Article

References (30)

1. Blaszczyk, J. W., and C. Dobrzecka. Effects of unilateral somatosensory cortex lesion upon locomotion in dogs. Acta Neurobiol. Exp. (Wars) 55:133-140, 1995.
2. Blumbergs, P. C., G. Scott, J. Manavis, H. Wainwright, D. A. Simpson, and A. J. McLean. Staining of amyloid precursor protein to study axonal damage in mild head injury. Lancet 344:1055-1056, 1994.
3. CDC. Sports-related recurrent brain injuries - United States. MMWR Morb. Mortal. Wkly. Rep. 46:224-227, 1997.
4. Cernak, I., Z. Wang, J. Jiang, X. Bian, and J. Savic. Ultrastructural and functional characteristics of blast injury-induced neurotrauma. J. Trauma 50:695-706, 2001.
5. Chen, Z., L. Y. Leung, A. Mountney, Z. Liao, W. Yang, X. C. Lu, J. Dave, Y. Deng-Bryant, G. Wei, K. Schmid, D. A. Shear, and F. C. Tortella. A novel animal model of closed-head concussive-induced mild traumatic brain injury: development, implementation, and characterization. J. Neurotrauma. 29:268-280, 2012.
6. Cole, J. T., A. Yarnell, W. S. Kean, E. Gold, B. Lewis, M. Ren, D. C. McMullen, D. M. Jacobowitz, H. B. Pollard, J. T. O'Neill, N. E. Grunberg, C. L. Dalgard, J. A. Frank, and W. D. Watson. Craniotomy: true sham for traumatic brain injury, or a sham of a sham? J. Neurotrauma. 28:359-369, 2011.
7. Creeley, C. E., D. F. Wozniak, P. V. Bayly, J. W. Olney, and L. M. Lewis. Multiple episodes of mild traumatic brain injury result in impaired cognitive performance in mice. Acad. Emerg. Med. 11:809-819, 2004.
8. Deliagina, T. G., G. N. Orlovsky, P. V. Zelenin, and I. N. Beloozerova. Neural bases of postural control. Physiology (Bethesda) 21:216-225, 2006.
9. Dewitt, D. S., R. Perez-Polo, C. E. Hulsebosch, P. K. Dash, and C. S. Robertson. Challenges in the development of rodent models of mild traumatic brain injury. J. Neurotrauma 30:688-701, 2013.
10. DVBIC. DoD Worldwide Numbers for TBI. 2013. http://www.dvbic.org/dod- worldwide-numbers-tbi.
11. Gennarelli, T. A., L. E. Thibault, J. H. Adams, D. I. Graham, C. J. Thompson, and R. P. Marcincin. Diffuse axonal injury and traumatic coma in the primate. Ann. Neurol. 12:564-574, 1982.
12. Godde, B., T. Berkefeld, M. David-Jurgens, and H. R. Dinse. Age-related changes in primary somatosensory cortex of rats: evidence for parallel degenerative and plastic-adaptive processes. Neurosci. Biobehav. Rev. 26:743-752, 2002.
13. Goldstein, L. E., A. M. Fisher, C. A. Tagge, X. L. Zhang, L. Velisek, J. A. Sullivan, C. Upreti, J. M. Kracht, M. Ericsson, M. W. Wojnarowicz, C. J. Goletiani, G. M. Maglakelidze, N. Casey, J. A. Moncaster, O. Minaeva, R. D. Moir, C. J. Nowinski, R. A. Stern, R. C. Cantu, J. Geiling, J. K. Blusztajn, B. L. Wolozin, T. Ikezu, T. D. Stein, A. E. Budson, N. W. Kowall, D. Chargin, A. Sharon, S. Saman, G. F. Hall, W. C. Moss, R. O. Cleveland, R. E. Tanzi, P. K. Stanton, and A. C. McKee. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci. Transl. Med. 4:134ra160, 2012.
14. Grant, R. A., B. Mitchinson, and T. J. Prescott. The development of whisker control in rats in relation to locomotion. Dev. Psychobiol. 54:151-168, 2012.
15. Hicks, R. R., V. B. Martin, L. Zhang, and K. B. Seroogy. Mild experimental brain injury differentially alters the expression of neurotrophin and neurotrophin receptor mRNAs in the hippocampus. Exp. Neurol. 160:469-478, 1999.
16. Hodgson, V., L. Thomas, and T. Khalil. Twenty-seventh stapp car crash conference proceedings (P-134) with International Research Committee on Biokinetics of Impacts (IRCOBI), San Diego, California, October 17-19, 1983.
17. Hong, Y., and R. Bartlett. Routledge handbook of biomechanics and human movement science. New York: Routledge, 2010.
18. Lewen, A., G. L. Li, P. Nilsson, Y. Olsson, and L. Hillered. Traumatic brain injury in rat produces changes of beta-amyloid precursor protein immunoreactivity. Neuroreport 6:357-360, 1995.
19. Martini, D. N., M. J. Sabin, S. A. DePesa, E. W. Leal, T. N. Negrete, J. J. Sosnoff, and S. P. Broglio. The chronic effects of concussion on gait. Arch. Phys. Med. Rehabil. 92:585-589, 2011.
20. Myer, D. J., G. G. Gurkoff, S. M. Lee, D. A. Hovda, and M. V. Sofroniew. Essential protective roles of reactive astrocytes in traumatic brain injury. Brain 129:2761-2772, 2006.
21. Nahum, A. M., and J. Melvin. Accidental injury: biomechanics and prevention. Berlin: Springer, 2002.
22. Nilsson, B., U. Ponten, and G. Voigt. Experimental head injury in the rat. Part 1: mechanics, pathophysiology, and morphology in an impact acceleration trauma model. J. Neurosurg. 47:241-251, 1977.
23. Paxinos, G., and C. Watson. The rat brain in stereotaxic coordinates: hard cover edition. New York: Elsevier, 2006.
24. Prins, M. L., A. Hales, M. Reger, C. C. Giza, and D. A. Hovda. Repeat traumatic brain injury in the juvenile rat is associated with increased axonal injury and cognitive impairments. Dev. Neurosci. 32:510-518, 2010.
25. Shitaka, Y., H. T. Tran, R. E. Bennett, L. Sanchez, M. A. Levy, K. Dikranian, and D. L. Brody. Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivity. J. Neuropathol. Exp. Neurol. 70:551-567, 2011.
26. Shultz, S. R., F. Bao, V. Omana, C. Chiu, A. Brown, and D. P. Cain. Repeated mild lateral fluid percussion brain injury in the rat causes cumulative long-term behavioral impairments, neuroinflammation, and cortical loss in an animal model of repeated concussion. J. Neurotrauma 29:281-294, 2012.
27. Smith, D. H., X. H. Chen, M. Nonaka, J. Q. Trojanowski, V. M. Lee, K. E. Saatman, M. J. Leoni, B. N. Xu, J. A. Wolf, and D. F. Meaney. Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig. J. Neuropathol. Exp. Neurol. 58:982-992, 1999.
28. Smith, D. H., D. F. Meaney, and W. H. Shull. Diffuse axonal injury in head trauma. J. Head Trauma Rehabil. 18:307-316, 2003.
29. Vandeputte, C., J. M. Taymans, C. Casteels, F. Coun, Y. Ni, K. Van Laere, and V. Baekelandt. Automated quantitative gait analysis in animal models of movement disorders. BMC Neurosci. 11:92, 2010.
30. Viano, D. C., A. Hamberger, H. Bolouri, and A. Saljo. Evaluation of three animal models for concussion and serious brain injury. Ann. Biomed. Eng. 40:213-226, 2012.