Bmi-1 regulates epithelial-to-mesenchymal transition to promote migration and invasion of breast cancer cells

International Journal of Clinical and Experimental Pathology

Volumn 7, Issue 6, 2014, Pages 3057-3064

  Li, Haiyu ^a   Song, Fangzhou ^a   Chen, Xingfeng ^a   Li, Yun ^a   Fan, Jianjun ^a   Wu, Xiangmei ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Bmi 1; Breast cancer; EMT; Invasion; Migration

Indexed keywords

BMI1 PROTEIN; BMI1 PROTEIN, HUMAN; SMALL INTERFERING RNA;

BREAST TUMOR; CELL MOTION; CELL SEPARATION; DISEASE COURSE; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; FLOW CYTOMETRY; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; IMMUNOBLOTTING; METABOLISM; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; TUMOR CELL LINE; TUMOR INVASION;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL SEPARATION; DISEASE PROGRESSION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; FLOW CYTOMETRY; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOBLOTTING; NEOPLASM INVASIVENESS; POLYCOMB REPRESSIVE COMPLEX 1; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TISSUE ARRAY ANALYSIS; TRANSFECTION;

EID: 84904328593     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. van Lohuizen M, Verbeek S, Scheijen B, Wientjens E, van der Gulden H and Berns A. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell 1991; 65: 737-752.
2. Joensuu K, Hagström J, Leidenius M, Haglund C, Andersson L, Sariola H and Heikkilä P. Bmi-1, c-myc, and Snail expression in primary breast cancers and their metastases-elevated Bmi-1 expression in late breast cancer relapses. Virchows Archiv 2011; 459: 31-39.
3. Lukacs RU, Memarzadeh S, Wu H and Witte ON. Bmi-1 Is a Crucial Regulator of Prostate Stem Cell Self-Renewal and Malignant Transformation. Cell Stem Cell 2010; 7: 682-693.
4. Kim JH, Yoon SY, Jeong SH, Kim SY, Moon SK, Joo JH, Lee Y, Choe IS and Kim JW. Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer. Breast 2004; 13: 383-388.
5. Song W, Tao K, Li H, Jin C, Song Z, Li J, Shi H, Li X, Dang Z and Dou K. Bmi-1 is related to proliferation, survival and poor prognosis in pancreatic cancer. Cancer Sci 2010; 101: 1754-1760.
6. Cui H, Hu B, Li T, Ma J, Alam G, Gunning WT and Ding HF. Bmi-1 Is Essential for the Tumorigenicity of Neuroblastoma Cells. Am J Pathol 2007; 170: 1370-1378.
7. Ye QH, Qin LX, Forgues M, He P, Kim JW, Peng AC, Simon R, Li Y, Robles AI, Chen Y, Ma ZC, Wu ZQ, Ye SL, Liu YK, Tang ZY and Wang XW. Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med 2003; 9: 416-423.
8. Wu J, Hu D, Yang G, Zhou J, Yang C, Gao Y and Zhu Z. Down-regulation of BMI-1 cooperates with artemisinin on growth inhibition of nasopharyngeal carcinoma cells. J Cell Biochem 2011; 112: 1938-1948.
9. Park IK, Morrison SJ and Clarke MF. Bmi1, stem cells, and senescence regulation. J Clin Invest 2004; 113: 175-179.
10. Yang J and Weinberg RA. Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis. Dev Cell 2008; 14: 818-829.
11. Thiery JP, Acloque H, Huang RYJ and Nieto MA. Epithelial-Mesenchymal Transitions in Development and Disease. Cell 2009; 139: 871-890.
12. Yilmaz M and Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 2009; 28: 15-33.
13. Birchmeier W and Birchmeier C. Epithelial-mesenchymal transitions in development and tumor progression. EXS 1995; 74: 1-15.
14. Onder TT, Gupta PB, Mani SA, Yang J, Lander ES and Weinberg RA. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 2008; 68: 3645-3654.
15. Allred DC, Clark GM, Elledge R, Fuqua SA, Brown RW, Chamness GC, Osborne CK and McGuire WL. Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J Natl Cancer Inst 1993; 85: 200-206.
16. Tiwari N, Gheldof A, Tatari M and Christofori G. EMT as the ultimate survival mechanism of cancer cells. Semin Cancer Biol 2012; 22: 194-207.
17. Schmalhofer O, Brabletz S and Brabletz T. E-cadherin, ß-catenin, and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev 2009; 28: 151-166.
18. Song LB, Zeng MS, Liao WT, Zhang L, Mo HY, Liu WL, Shao JY, Wu QL, Li MZ, Xia YF, Fu LW, Huang WL, Dimri GP, Band V and Zeng YX. Bmi-1 Is a Novel Molecular Marker of Nasopharyngeal Carcinoma Progression and Immortalizes Primary Human Nasopharyngeal Epithelial Cells. Cancer Res 2006; 66: 6225-6232.
19. Song LB, Li J, Liao WT, Feng Y, Yu CP, Hu LJ, Kong QL, Xu LH, Zhang X, Liu WL, Li MZ, Zhang L, Kang TB, Fu LW, Huang WL, Xia YF, Tsao SW, Li M, Band V, Band H, Shi QH, Zeng YX and Zeng MS. The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest 2009; 119: 3626-3636.
20. Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ and Clarke MF. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003; 423: 302-305.