Gene-environmental interaction between smoking and shared epitope on the development of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: A meta-analysis

International Journal of Rheumatic Diseases

Volumn 17, Issue 5, 2014, Pages 528-535

  Lee, Young Ho ^a   Bae, Sang Cheol ^b   Song, Gwan Gyu ^a  

^a Korea University College of Medicine   (South Korea)

^b Hanyang University Medical Center   (South Korea)

Author keywords

Anti CCP antibodies; Rheumatoid arthritis; Shared epitope; Smoking

Indexed keywords

CYCLIC CITRULLINATED PEPTIDE ANTIBODY; EPITOPE; SHARED EPITOPE; UNCLASSIFIED DRUG; AUTOANTIBODY; BIOLOGICAL MARKER; CYCLIC CITRULLINATED PEPTIDE; CYCLOPEPTIDE; HLA ANTIGEN CLASS 2;

ANTIBODY BLOOD LEVEL; ARTICLE; ASIAN; CLINICAL EVALUATION; COCHRANE LIBRARY; EMBASE; ENVIRONMENTAL EXPOSURE; ETHNICITY; EUROPEAN AMERICAN; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; LABORATORY TEST; MEDLINE; META ANALYSIS; MULTICENTER STUDY (TOPIC); PREDICTIVE VALUE; PRIORITY JOURNAL; PUBLISHING; RHEUMATOID ARTHRITIS; RISK FACTOR; SMOKING; SYSTEMATIC REVIEW; TOBACCO; ADVERSE EFFECTS; ARTHRITIS, RHEUMATOID; BLOOD; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; PHENOTYPE; RISK;

ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; BIOLOGICAL MARKERS; EPITOPES; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; ODDS RATIO; PEPTIDES, CYCLIC; PHENOTYPE; RISK FACTORS; SMOKING;

EID: 84904325776     PISSN: 17561841     EISSN: 1756185X     Source Type: Journal    
DOI: 10.1111/1756-185X.12307     Document Type: Article

References (36)

1. Harris ED Jr (1990) Rheumatoid arthritis. Pathophysiology and implications for therapy. N Engl J Med 322, 1277-89.
2. Kim HR, Park MK, Cho ML et al. (2010) Induction of macrophage migration inhibitory factor in ConA-stimulated rheumatoid arthritis synovial fibroblasts through the P38 map kinase-dependent signaling pathway. Korean J Intern Med 25, 317-26.
3. MacGregor AJ, Snieder H, Rigby AS et al. (2000) Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum 43, 30-7.
4. Deighton CM, Walker DJ, Griffiths ID, Roberts DF (1989) The contribution of HLA to rheumatoid arthritis. Clin Genet 36, 178-82.
5. Karlson EW, Lee IM, Cook NR, Manson JE, Buring JE, Hennekens CH (1999) A retrospective cohort study of cigarette smoking and risk of rheumatoid arthritis in female health professionals. Arthritis Rheum 42, 910-7.
6. Choi SJ, Rho YH, Ji JD, Song GG, Lee YH (2006) Genome scan meta-analysis of rheumatoid arthritis. Rheumatology (Oxford) 45, 166-70.
7. du Montcel ST, Michou L, Petit-Teixeira E et al. (2005) New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility. Arthritis Rheum 52, 1063-8.
8. Stolt P, Bengtsson C, Nordmark B et al. (2003) Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases. Ann Rheum Dis 62, 835-41.
9. Silman AJ, Newman J, MacGregor AJ (1996) Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins. Arthritis Rheum 39, 732-5.
10. Asaga H, Yamada M, Senshu T (1998) Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages. Biochem Biophys Res Commun 243, 641-6.
11. van Gaalen F, Ioan-Facsinay A, Huizinga TW, Toes RE (2005) The devil in the details: the emerging role of anticitrulline autoimmunity in rheumatoid arthritis. J Immunol 175, 5575-80.
12. van Gaalen FA, van Aken J, Huizinga TW et al. (2004) Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis. Arthritis Rheum 50, 2113-21.
13. Linn-Rasker SP, van der Helm-van Mil AH, van Gaalen FA et al. (2006) Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles. Ann Rheum Dis 65, 366-71.
14. Michou L, Teixeira VH, Pierlot C et al. (2008) Associations between genetic factors, tobacco smoking and autoantibodies in familial and sporadic rheumatoid arthritis. Ann Rheum Dis 67, 466-70.
15. Lee HS, Irigoyen P, Kern M et al. (2007) Interaction between smoking, the shared epitope, and anti-cyclic citrullinated peptide: a mixed picture in three large North American rheumatoid arthritis cohorts. Arthritis Rheum 56, 1745-53.
16. Pedersen M, Jacobsen S, Garred P et al. (2007) Strong combined gene-environment effects in anti-cyclic citrullinated peptide-positive rheumatoid arthritis: a nationwide case-control study in Denmark. Arthritis Rheum 56, 1446-53.
17. van der Helm-van Mil AH, Verpoort KN, le Cessie S, Huizinga TW, de Vries RR, Toes RE (2007) The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide. Arthritis Rheum 56, 425-32.
18. Klareskog L, Stolt P, Lundberg K et al. (2006) A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 54, 38-46.
19. Too CL, Yahya A, Murad S et al. (2012) Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA). Arthritis Res Ther 14, R89.
20. Nath SK, Harley JB, Lee YH (2005) Polymorphisms of complement receptor 1 and interleukin-10 genes and systemic lupus erythematosus: a meta-analysis. Hum Genet 118, 225-34.
21. Lee YH, Rho YH, Choi SJ, Ji JD, Song GG (2006) Association of TNF-alpha -308 G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis. Rheumatol Int 27, 157-61.
22. Lee YH, Nath SK (2005) Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis. Hum Genet 118, 434-43.
23. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21, 1539-58.
24. Egger M, Smith GD, Phillips AN (1997) Meta-analysis: principles and procedures. BMJ 315, 1533-7.
25. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7, 177-88.
26. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315, 629-34.
27. Lundberg K, Bengtsson C, Kharlamova N et al. (2012) Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile. Ann Rheum Dis 72, 652-8.
28. van Beers JJ, Willemze A, Stammen-Vogelzangs J, Drijfhout JW, Toes RE, Pruijn GJ (2012) Anti-citrullinated fibronectin antibodies in rheumatoid arthritis are associated with human leukocyte antigen-DRB1 shared epitope alleles. Arthritis Res Ther 14, R35.
29. Bang SY, Lee KH, Cho SK, Lee HS, Lee KW, Bae SC (2010) Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status. Arthritis Rheum 62, 369-77.
30. Mahdi H, Fisher BA, Kallberg H et al. (2009) Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis. Nat Genet 41, 1319-24.
31. Oliveira RD, Junta CM, Oliveira FR, Silva LM, Donadi EA, Louzada-Junior P (2008) Share epitope, citrullinated cyclic peptide antibodies and smoking in Brazilian rheumatoid arthritis patients. Clin Rev Allergy Immunol 34, 32-5.
32. Verpoort KN, Papendrecht-van der Voort EA, van der Helm-van Mil AH et al. (2007) Association of smoking with the constitution of the anti-cyclic citrullinated peptide response in the absence of HLA-DRB1 shared epitope alleles. Arthritis Rheum 56, 2913-8.
33. Vossenaar ER, Smeets TJ, Kraan MC, Raats JM, van Venrooij WJ, Tak PP (2004) The presence of citrullinated proteins is not specific for rheumatoid synovial tissue. Arthritis Rheum 50, 3485-94.
34. Vossenaar ER, van Venrooij WJ (2004) Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis. Arthritis Res Ther 6, 107-11.
35. Huizinga TW, Amos CI, van der Helm-van Mil AH et al. (2005) Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum 52, 3433-8.
36. Wolfe F (2000) The effect of smoking on clinical, laboratory, and radiographic status in rheumatoid arthritis. J Rheumatol 27, 630-7.