N-phenacylthiazolium bromide inhibits the advanced glycation end product (AGE)-age receptor axis to modulate experimental periodontitis in rats

Journal of Periodontology

Volumn 85, Issue 7, 2014, Pages

  Chang, Po Chun ^a   Tsai, Sheng Chueh ^b   Chong, Li Yen ^c   Kao, Man Jung ^c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Gene expression; Glycosylation end products, advanced; Immunohistochemistry; Periodontitis; Thiazoles; X ray microtomography

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCOSYLATION END-PRODUCT RECEPTOR; CELL ADHESION MOLECULE; COLLAGEN TYPE 1; FIBRONECTIN; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; IMMUNOGLOBULIN RECEPTOR; N-PHENACYLTHIAZOLIUM BROMIDE; POSTN PROTEIN, RAT; THIAZOLE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ALVEOLAR BONE LOSS; ANALYSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL SURVIVAL; CULTURE TECHNIQUE; CYTOLOGY; DISEASE COURSE; DISEASE MODEL; DRUG EFFECTS; GLUCOSE BLOOD LEVEL; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; PERIODONTAL LIGAMENT; PERIODONTITIS; RAT; SPRAGUE DAWLEY RAT;

ALVEOLAR BONE LOSS; ANIMALS; BLOOD GLUCOSE; CELL ADHESION MOLECULES; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; COLLAGEN TYPE I; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FIBRONECTINS; GLYCOSYLATION END PRODUCTS, ADVANCED; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PERIODONTAL LIGAMENT; PERIODONTITIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, IMMUNOLOGIC; THIAZOLES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84904323420     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2014.130554     Document Type: Article

References (28)

1. Abbass MM, Korany NS, Salama AH, Dmytryk JJ, Safiejko-Mroczka B. The relationship between receptor for advanced glycation end products expression and the severity of periodontal disease in the gingiva of diabetic and non diabetic periodontitis patients. Arch Oral Biol 2012;57:1342-1354.
2. Lalla E, Lamster IB, Stern DM, Schmidt AM. Receptor for advanced glycation end products, inflammation, and accelerated periodontal disease in diabetes: Mechanisms and insights into therapeutic modalities. Ann Periodontol 2001;6:113-118.
3. Mealey BL, Oates TW; American Academy of Periodontology. Diabetes mellitus and periodontal diseases. J Periodontol 2006;77:1289-1303.
4. Lalla E, Lamster IB, Feit M, et al. Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice. J Clin Invest 2000;105:1117-1124.
5. Katz J, Bhattacharyya I, Farkhondeh-Kish F, Perez FM, Caudle RM, Heft MW. Expression of the receptor of advanced glycation end products in gingival tissues of type 2 diabetes patients with chronic periodontal disease: A study utilizing immunohistochemistry and RT-PCR. J Clin Periodontol 2005;32:40-44.
6. Chang PC, Chien LY, Chong LY, Kuo YP, Hsiao JK. Glycated matrix up-regulates inflammatory signaling similarly to Porphyromonas gingivalis lipopolysaccharide. J Periodontal Res 2013;48:184-193.
7. Chang PC, Chien LY, Yeo JF, et al. Progression of periodontal destruction and the roles of advanced glycation end products in experimental diabetes. J Periodontol 2013;84:379-388.
8. Nagai R, Murray DB, Metz TO, Baynes JW. Chelation: A fundamental mechanism of action of AGE inhibitors, AGE breakers, and other inhibitors of diabetes complications. Diabetes 2012;61:549-559.
9. Engelen L, Stehouwer CD, Schalkwijk CG. Current therapeutic interventions in the glycation pathway: Evidence from clinical studies. Diabetes Obes Metab 2013:15:677-689.
10. Vasan S, Zhang X, Zhang X, et al. An agent cleaving glucose-derived protein crosslinks in vitro and in vivo. Nature 1996;382:275-278.
11. Cooper ME, Thallas V, Forbes J, et al. The cross-link breaker, N-phenacylthiazolium bromide prevents vascular advanced glycation end-product accumulation. Diabetologia 2000;43:660-664.
12. Wolffenbuttel BH, Boulanger CM, Crijns FR, et al. Breakers of advanced glycation end products restore large artery properties in experimental diabetes. Proc Natl Acad Sci USA 1998;95:4630-4634.
13. Tikellis C, Thomas MC, Harcourt BE, et al. Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs. Am J Physiol Endocrinol Metab 2008;295:E323-E330.
14. Chang PC, Chong LY, Tsai SC, Lim LP. Aminoguanidine inhibits the AGE-RAGE axis to modulate the induction of periodontitis but has limited effects on the progression and recovery of experimental periodontitis: A preliminary study [published online ahead of print July 15, 2013]. J Periodontol. doi:10.1902/jop.2013.130238.
15. Chandra KP, Shiwalkar A, Kotecha J, et al. Phase I clinical studies of the advanced glycation end-product (AGE)-breaker TRC4186: Safety, tolerability and pharmacokinetics in healthy subjects. Clin Drug Investig 2009;29:559-575.
16. Rios HF, Ma D, Xie Y, et al. Periostin is essential for the integrity and function of the periodontal ligament during occlusal loading in mice. J Periodontol 2008; 79:1480-1490.
17. Ericsson I, Lindhe J, Rylander H, Okamoto H. Experimental periodontal breakdown in the dog. Scand J Dent Res 1975;83:189-192.
18. Schroeder HE, Lindhe J. Conditions and pathological features of rapidly destructive, experimental periodontitis in dogs. J Periodontol 1980;51:6-19.
19. Graves DT. The potential role of chemokines and inflammatory cytokines in periodontal disease progression. Clin Infect Dis 1999;28:482-490.
20. Jang Y, Kim JY, Kang SM, et al. Association of the Gly82Ser polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating levels of soluble RAGE and inflammatory markers in nondiabetic and nonobese Koreans. Metabolism 2007;56:199-205.
21. Isaka J, Ohazama A, Kobayashi M, et al. Participation of periodontal ligament cells with regeneration of alveolar bone. J Periodontol 2001;72:314-323.
22. Oates TW, Graves DT, Cochran DL. Clinical, radiographic and biochemical assessment of IL-1/TNFalpha antagonist inhibition of bone loss in experimental periodontitis. J Clin Periodontol 2002;29:137-143.
23. Valencia JV, Mone M, Zhang J, Weetall M, Buxton FP, Hughes TE. Divergent pathways of gene expression are activated by the RAGE ligands S100b and AGE-BSA. Diabetes 2004;53:743-751.
24. Kamide T, Kitao Y, Takeichi T, et al. RAGE mediates vascular injury and inflammation after global cerebral ischemia. Neurochem Int 2012;60:220-228.
25. Pacios S, Kang J, Galicia J, et al. Diabetes aggravates periodontitis by limiting repair through enhanced inflammation. FASEB J 2012;26:1423-1430.
26. Cirelli JA, Park CH, MacKool K, et al. AAV2/1-TNFR:Fc gene delivery prevents periodontal disease progression. Gene Ther 2009;16:426-436.
27. Andriankaja OM, Galicia J, Dong G, Xiao W, Alawi F, Graves DT. Gene expression dynamics during diabetic periodontitis. J Dent Res 2012;91:1160-1165.
28. Hartog JW, Willemsen S, van Veldhuisen DJ, et al; BENEFICIAL Investigators. Effects of alagebrium, an advanced glycation endproduct breaker, on exercise tolerance and cardiac function in patients with chronic heart failure. Eur J Heart Fail 2011;13:899-908.