Genetic versus non-genetic regulation of miR-103, miR-143 and miR-483-3p expression in adipose tissue and their metabolic implications - A twin study

Genes

Volumn 5, Issue 3, 2014, Pages 508-517

  Bork Jensen, Jette ^a,b   Thuesen, Anne Cathrine Baun ^a,b   Bang Bertelsen, Claus Heiner ^c,d   Grunnet, Louise Groth ^a,b   Pociot, Flemming ^d,e   Beck Nielsen, Henning ^f   Ozanne, Susan E ^g   Poulsen, Pernille ^h   Vaag, Allan ^a,b  

^a International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^b STENO DIABETES CENTER   (Denmark)

^c GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^f ODENSE UNIVERSITY HOSPITAL   (Denmark)

^g INSTITUTE OF METABOLIC SCIENCE   (United Kingdom)

^h NOVO NORDISK A S   (Denmark)

Author keywords

Human metabolism; Micrornas; Subcutaneous adipose tissue; Twins

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; MICRORNA; MICRORNA 103; MICRORNA 143; MICRORNA 483 3P; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ARTICLE; BIRTH WEIGHT; BODY MASS; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DIZYGOTIC TWINS; ENVIRONMENTAL FACTOR; FEMALE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HEREDITY; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; OBESITY; PHENOTYPE; REAL TIME POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT; TREND STUDY;

EID: 84904310787     PISSN: None     EISSN: 20734425     Source Type: Journal    
DOI: 10.3390/genes5030508     Document Type: Article

References (24)

1. Bartel, D. P. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 2004, 116, 281-297.
2. Friedman, R. C.; Farh, K. K.-H.; Burge, C. B.; Bartel, D. P. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009, 19, 92-105.
3. Xie, H.; Lim, B.; Lodish, H. F. MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes 2009, 58, 1050-1057.
4. Trajkovski, M.; Hausser, J.; Soutschek, J.; Bhat, B.; Akin, A.; Zavolan, M.; Heim, M. H.; Stoffel, M. MicroRNAs 103 and 107 regulate insulin sensitivity. Nature 2011, 474, 649-653.
5. Takanabe, R.; Ono, K.; Abe, Y.; Takaya, T.; Horie, T.; Wada, H.; Kita, T.; Satoh, N.; Shimatsu, A.; Hasegawa, K. Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet. Biochem. Biophys. Res. Commun. 2008, 376, 728-732.
6. Jordan, S. D.; Kruger, M.; Willmes, D. M.; Redemann, N.; Wunderlich, F. T.; Bronneke, H. S.; Merkwirth, C.; Kashkar, H.; Olkkonen, V. M.; Bottger, T.; et al. Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nat. Cell Biol. 2011, 13, 434-446.
7. Duan, R.; Pak, C.; Jin, P. Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA. Hum. Mol. Genet. 2007, 16, 1124-1131.
8. Sun, T.; Fu, M.; Bookout, A. L.; Kliewer, S. A.; Mangelsdorf, D. J. MicroRNA let-7 regulates 3T3-L1 adipogenesis. Mol. Endocrinol. 2009, 23, 925-931.
9. Ferland-McCollough, D.; Fernandez-Twinn, D. S.; Cannell, I. G.; David, H.; Warner, M.; Vaag, A. A.; Bork-Jensen, J.; Brons, C.; Gant, T. W.; Willis, A. E.; et al. Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes. Cell Death Differ. 2012, 19, 1003-1012.
10. Hales, C. N.; Barker, D. J. The thrifty phenotype hypothesis. Br. Med. Bull. 2001, 60, 5-20.
11. Vaag, A.; Jensen, C. B.; Poulsen, P.; Brons, C.; Pilgaard, K.; Grunnet, L.; Vielwerth, S.; Alibegovic, A. Metabolic aspects of insulin resistance in individuals born small for gestational age. Horm. Res. Paediatr. 2006, 65, 137-143.
12. Poulsen, P.; Ohm Kyvik, K.; Vaag, A.; Beck-Nielsen, H. Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance-A population-based twin study. Diabetologia 1999, 42, 139-145.
13. Grunnet, L. G.; Nilsson, E.; Ling, C.; Hansen, T.; Pedersen, O.; Groop, L.; Vaag, A.; Poulsen, P. Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue. Diabetes 2009, 58, 2402-2408.
14. Poulsen, P.; Grunnet, L. G.; Pilgaard, K.; Storgaard, H.; Alibegovic, A.; Sonne, M. P.; Carstensen, B.; Beck-Nielsen, H.; Vaag, A. Increased risk of type 2 diabetes in elderly twins. Diabetes 2009, 58, 1350-1355.
15. Matthews, D. R.; Hosker, J. P.; Rudenski, A. S.; Naylor, B. A.; Treacher, D. F.; Turner, R. C. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28, 412-419.
16. Bring, J.; Wernroth, L. Inefficient analysis of twin data: Is there an association between diabetes and birth weight? Diabetologia 1999, 42, 898-899.
17. Poulsen, P.; Vaag, A.; Beck-Nielsen, H. The influence of zygosity status on blood pressure and on lipid profiles in male and female twins. J. Hypertens. 2002, 20, 654-659.
18. Ryan, B. M.; Robles, A. I.; Harris, C. C. Genetic variation in microRNA networks: The implications for cancer research. Nat. Rev. Cancer 2010, 10, 389-402.
19. Mohan, S.; Farley, J. R.; Baylink, D. J. Age-related changes in IGFBP-4 and IGFBP-5 levels in human serum and bone: Implications for bone loss with aging. Prog. Growth Factor Res. 1995, 6, 465-473.
20. Garite, T. J.; Clark, R. H.; Elliott, J. P.; Thorp, J. A.; The Pediatrix/Obstetrix Perinatal Research Group. Twins and triplets: The effect of plurality and growth on neonatal outcome compared with singleton infants. Am. J. Obstet. Gynecol. 2004, 191, 700-707.
21. Ortega, F. J.; Moreno-Navarrete, J. M.; Pardo, G.; Sabater, M.; Hummel, M.; Ferrer, A.; Rodriguez-Hermosa, J. I.; Ruiz, B.; Ricart, W.; Peral, B.; et al. MiRNA expression profile of human subcutaneous adipose and during adipocyte differentiation. PLoS One 2010, 5, e9022.
22. Klöting, N.; Berthold, S.; Kovacs, P.; Schön, M. R.; Fasshauer, M.; Ruschke, K.; Stumvoll, M.; Blüher, M. MicroRNA expression in human omental and subcutaneous adipose tissue. PLoS One 2009, 4, e4699.
23. Yan, D.; Mäyränpää, M. I.; Wong, J.; Perttilä, J.; Lehto, M.; Jauhiainen, M.; Kovanen, P. T.; Ehnholm, C.; Brown, A. J.; Olkkonen, V. M.; et al. OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages. J. Biol. Chem. 2008, 283, 332-340.
24. Poulsen, P.; Levin, K.; Beck-Nielsen, H.; Vaag, A. Age-dependent impact of zygosity and birth weight on insulin secretion and insulin action in twins. Diabetologia 2002, 45, 1649-1657.