Chaperonins resculpt folding free energy landscapes to avoid kinetic traps and accelerate protein folding

Journal of Molecular Biology

Volumn 426, Issue 15, 2014, Pages 2736-2738

  Zhang, Xin ^a   Kelly, Jeffery W ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONIN; MALTOSE BINDING PROTEIN; TRYPTOPHAN;

ACCELERATION; CATALYSIS; CHEMICAL ENVIRONMENT; CONFORMATION; ELECTRON; ELECTRON TRANSPORT; ENCAPSULATION; ENERGY; ENTROPY; EUKARYOTIC CELL; FLUORESCENCE CORRELATION SPECTROSCOPY; HUMAN; KINETICS; LANDSCAPE; MICROENVIRONMENT; MUTAGENESIS; NOTE; PRIORITY JOURNAL; PROKARYOTE; PROTEIN AGGREGATION; PROTEIN FOLDING; REDUCTION; WILD TYPE; CATALYST;

CHAPERONIN 10; CHAPERONIN 60; ESCHERICHIA COLI; PROTEIN FOLDING;

EID: 84904264776     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2014.06.001     Document Type: Note

References (5)

1. A.J. Gupta, S. Haldar, G. Milicic, F.U. Hartl, and M. Hayer-Hartl Active cage mechanism of chaperonin-assisted protein folding demonstrated at single molecule level J Mol Biol 426 2014 2739 2754
2. K. Chakraborty, M. Chatila, J. Sinha, Q. Shi, B.C. Poschner, and M. Sikor et al. Chaperonin-catalyzed rescue of kinetically trapped states in protein folding Cell 142 2010 112 122
3. A. Brinker, G. Pfeifer, M.J. Kerner, D.J. Naylor, F.U. Hartl, and M. Hayer-Hartl Dual function of protein confinement in chaperonin-assisted protein folding Cell 107 2001 223 233
4. Z. Lin, and H.S. Rye Expansion and compression of a protein folding intermediate by GroEL Mol Cell 16 2004 23 34
5. F. Georgescauld, K. Popova, A.J. Gupta, A. Bracher, J.R. Engen, and M. Hayer-Hartl et al. GroEL/ES chaperonin modulates the mechanism and accelerates the rate of TIM-barrel domain folding Cell 157 2014 922 934