Clinical and serological study of myasthenia gravis using both radioimmunoprecipitation and cell-based assays in a South Asian population

Journal of the Neurological Sciences

Volumn 343, Issue 1-2, 2014, Pages 82-87

  Chang, Thashi ^a   Leite, Maria Isabel ^e   Senanayake, Sunethra ^c   Gunaratne, Padma S ^b   Gamage, Ranjanie ^b   Riffsy, M T M ^d   Jacobson, Leslie W ^e   Adhikari, Madura ^a   Perera, Sanja ^a   Vincent, Angela ^e  

^a UNIVERSITY OF COLOMBO   (Sri Lanka)

^b National Hospital   (Sri Lanka)

^c North Colombo Teaching Hospital   (Sri Lanka)

^d Professorial Surgical Unit   (Sri Lanka)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

AChR; Antibodies; MuSK; Myasthenia gravis; Sri Lanka

Indexed keywords

AUTOANTIBODY; CHOLINERGIC RECEPTOR ANTIBODY; MUSCLE SPECIFIC TYROSINE KINASE ANTIBODY; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; CHOLINERGIC RECEPTOR; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN;

ADULT; ANTIBODY TITER; ARTICLE; CELL ASSAY; CELL BASED ASSAY; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; MYASTHENIA GRAVIS; PRIORITY JOURNAL; QUESTIONNAIRE; RADIOIMMUNOPRECIPITATION; SEROPREVALENCE; BLOOD; EPIDEMIOLOGY; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PROCEDURES; SRI LANKA;

ADULT; AUTOANTIBODIES; FEMALE; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; MALE; MIDDLE AGED; MYASTHENIA GRAVIS; RADIOIMMUNOPRECIPITATION ASSAY; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CHOLINERGIC; SEROEPIDEMIOLOGIC STUDIES; SRI LANKA; TRANSFECTION;

EID: 84904256069     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2014.05.037     Document Type: Article

References (20)

1. J.M. Lindstrom, M.E. Seybold, V.A. Lennon, S. Whittingham, and D.D. Duane Antibody to acetylcholine receptor in myasthenia gravis: prevalence, clinical correlates, and diagnostic value Neurology 26 11 1976 1054 1059
2. D.B. Drachman Myasthenia gravis N Engl J Med 330 1994 1797 1810
3. A. Vincent Unravelling the pathogenesis of myasthenia gravis Nat Rev Immunol 2 2002 797 804
4. W. Hoch, J. McConville, S. Helms, J. Newsom-Davis, A. Melms, and A. Vincent Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies Nat Med. 7 2001 365 368
5. A. Vincent, and M.I. Leite Neuromuscular junction autoimmune disease: muscle specific kinase antibodies and treatments for myasthenia gravis Curr Opin Neurol 18 2005 519 525
6. A. Vincent, M.I. Leite, M.E. Farrugia, S. Jacob, S. Viegas, and H. Shiraishi et al. Myasthenia gravis seronegative for acetylcholine receptor antibodies Ann N Y Acad Sci 1132 2008 84 92
7. A. Vincent, P. Waters, M.I. Leite, L.W. Jacobson, I. Koneczny, and J. Cossins et al. Antibodies identified by cell-based assays in myasthenia gravis and associated diseases Ann N Y Acad Sci 1274 2012 92 98
8. M.I. Leite, S. Jacob, S. Viegas, J. Cossins, L. Clover, and B.P. Morgan et al. IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis Brain 131 2008 1940 1952
9. P.S. Gunaratne, H.A. Larsen, and A.K. Manatunga Effectiveness of immunotherapy in myasthenia gravis: epidemiological evidence from Sri Lanka Neurol Asia 10 2005 39 45
10. J.B. Peiris, S. Gunatilake, C. Wijeratne, and N. Gunatillake Myasthenia gravis in Sri Lanka Ceylon Med J 36 1991 155 158
11. A. Jaretzki, R.B. Barohn, R.M. Ernstoff, H.J. Kaminski, J.C. Keesey, and A.S. Penn et al. Myasthenia gravis. Recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America Neurology 55 2000 16 23
12. T. Chang, P. Gunaratne, R. Gamage, M.T.M. Riffsy, and A. Vincent MuSK-antibody-positive myasthenia gravis in South Asian population J Clin Neurosci 284 2009 33 35
13. A. Vincent, J. Palace, and D. Hilton-Jones Myasthenia gravis Lancet 357 2001 2122 2128
14. J.Y. Lee, J.J. Sung, J.Y. Cho, D.H. Oh, H.J. Kim, and J.H. Park et al. MuSK antibody-positive, seronegative myasthenia gravis in Korea J Clin Neurosci 13 2006 353 355
15. K. Ohta, K. Shigemoto, A. Fujinami, N. Maruyama, T. Konishi, and M. Ohta Clinical and experimental features of MuSK antibody positive MG in Japan Eur J Neurol 14 2007 1029 1034
16. R. Witoonpanich, C. Dejthevaporn, T. Pulkes, N.T.S.S. Tunlayadechanont, P. Boonkongchuen, and S. Pongpakdee et al. Prevalence, clinical features and treatment outcomes of patients with myasthenia gravis positive for antibodies to muscle-specific kinase in Thailand J Clin Neurosci 20 5 2013 707 709
17. J.H. Yeh, W.H. Chen, H.C. Chiu, and A. Vincent Low frequency of MuSK antibody in generalized seronegative myasthenia gravis among Chinese Neurology 62 2004 2131 2132
18. X. Zhang, M. Yang, J. Xu, M. Zhang, B. Lang, and W. Wang et al. Clinical and serological study of myasthenia gravis in HuBei Province, China J Neurol Neurosurg Psychiatry 78 2007 386 390
19. M.E. Farrugia, M.D. Robson, L. Clover, P. Anslow, J. Newsom-Davis, and R. Kennett et al. MRI and clinical studies of facial and bulbar muscle involvement in MuSK antibody-associated myasthenia gravis Brain 129 2006 1481 1492
20. A. Evoli, P.A. Tonali, L. Padua, M.L. Monaco, F. Scuderi, and A.P. Batocchi et al. Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis Brain 126 2003 2304 2311