Immunoregulation therapy changes the frequency of interleukin (IL)-22+CD4+ T cells in systemic lupus erythematosus patients

Clinical and Experimental Immunology

Volumn 177, Issue 1, 2014, Pages 212-218

  Zhao, L ^a   Ma, H ^a   Jiang, Z ^a   Jiang, Y ^a   Ma, N ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

Cyclophosphamide; IL 22; Systemic lupus erythematosus; Th22

Indexed keywords

CD4 ANTIGEN; CYCLOPHOSPHAMIDE; GAMMA INTERFERON; HYDROXYCHLOROQUINE; INTERLEUKIN 17; INTERLEUKIN 22; METHYLPREDNISOLONE;

ADULT; ARTICLE; BLOOD LEVEL; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HELPER CELL; HUMAN; IMMUNOPATHOGENESIS; IMMUNOREGULATION; IMMUNOTHERAPY; INTERLEUKIN 22+ CD4+ T LYMPHOCYTE; INTERLEUKIN 22+TH1 CELL; INTERLEUKIN 22+TH17 CELL; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; POLARIZATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH22 CELL;

CYCLOPHOSPHAMIDE; IL-22; SYSTEMIC LUPUS ERYTHEMATOSUS; TH22;

ADOLESCENT; ADULT; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINEAGE; CYCLOPHOSPHAMIDE; FEMALE; HOMEOSTASIS; HUMANS; HYDROXYCHLOROQUINE; IMMUNOMODULATION; IMMUNOSUPPRESSIVE AGENTS; IMMUNOTHERAPY; INTERFERON-GAMMA; INTERLEUKINS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; METHYLPREDNISOLONE; TH1 CELLS; YOUNG ADULT;

EID: 84904242098     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12330     Document Type: Article

References (25)

1. Schmidt-Weber CB, Akdis M, Akdis CA. TH17 cells in the big picture of immunology. J Allergy Clin Immunol 2007; 120:247-254.
2. + T lymphocytes. Cell Res 2006; 16:902-907.
3. Liang SC, Tan XY, Luxenberg DP etal. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 2006; 203:2271-2279.
4. + T cell function via L-arginine metabolism. Cancer Res 2009; 69:3086-3094.
5. Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol 2009; 10:857-863.
6. Trifari S, Kaplan CD, Tran EH, Crellin NK, Spits H. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)17, T(H)1 and T(H)2 cells. Nat Immunol 2009; 10:864-887.
7. Renauld JC. Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators. Nat Rev Immunol 2003; 3:667-676.
8. Wolk K, Witte E, Wallace E etal. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol 2006; 36:1309-1323.
9. Wolk K, Witte E, Hoffmann U etal. IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease. J Immunol 2007; 178:5973-5981.
10. Ikeuchi H, Kuroiwa T, Hiramatsu N etal. Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine. Arthritis Rheum 2005; 52:1037-1046.
11. Szegedi A, Simics E, Aleksza M etal. Ultraviolet-A1 phototherapy modulates Th1/Th2 and Tc1/Tc2 balance in patients with systemic lupus erythematosus. Rheumatology (Oxf) 2005; 44:925-931.
12. Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N Engl J Med 2009; 361:888-898.
13. Garrett-Sinha LA, John S, Gaffen SL. IL-17 and the Th17 lineage in systemic lupus erythematosus[J]. Curr Opin Rheumatol 2008; 20:519-525.
14. Eyerich S, Eyerich K, Pennino D etal. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest 2009; 119:3573-3585.
15. Trifari S, Kaplan C, Tran E, Crellin N, Spits H. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2cells. Nat Immunol 2009; 10:864-871.
16. + T-cells in patients with active systemic lupus erythematosus. Exp Biol Med (Maywood) 2013; 238:193-199.
17. Guo C, Chu X, Shi Y etal. Correction of Th1-dominant cytokine profiles by high-dose dexamethasone in patients with chronic idiopathic thrombocytopenic purpura. J Clin Immunol 2007; 27:557-562.
18. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401:708-712.
19. Tan EM. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol 1989; 44:93-151.
20. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH. Derivation of the SLEDAI. A disease activity index for lupus patients. The committee on prognosis studies in SLE. Arthritis Rheum 1992; 35:630-640.
21. Ziesché E, Scheiermann P, Bachmann M etal. Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo. Clin Exp Immunol 2009; 157:370-376.
22. Cao J, Chen C, Li L etal. Effects of high-dose dexamethasone on regulating interleukin-22 production and correcting Th1 and Th22 polarization in immune thrombocytopenia. J Clin Immunol 2012; 32:523-529.
23. Sperber K, Quraishi H, Kalb TH, Panja A, Stecher V, Mayer L. Selective regulation of cytokine secretion by hydroxychloroquine. Inhibition of interleukin 1 alpha (IL-1-alpha) and IL-6 in human monocytes and T cells. J Rheumatol 1993; 20:803-808.
24. Wolk K, Witte E, Witte K, Warszawska K, Sabat R. Biology of interleukin-22. Semin Immunopathol 2010; 32:17-31.
25. van Loosdregt J, Spreafico R, Rossetti M etal. Hydroxychloroquine preferentially induces apoptosis of CD45RO1 effector T cells by inhibiting autophagy: a possible mechanism for therapeutic modulation of T cells. J Allergy Clin Immunol 2013; 131:1443-1446.