Amphibians acquire resistance to live and dead fungus overcoming fungal immunosuppression

Nature

Volumn 511, Issue 7508, 2014, Pages 224-227

  McMahon, Taegan A ^a,b   Sears, Brittany F ^a   Venesky, Matthew D ^c   Bessler, Scott M ^a   Brown, Jenise M ^a   Deutsch, Kaitlin ^a   Halstead, Neal T ^a   Lentz, Garrett ^a   Tenouri, Nadia ^a   Young, Suzanne ^a   Civitello, David J ^a   Ortega, Nicole ^a   Fites, J Scott ^d   Reinert, Laura K ^e   Rollins Smith, Louise A ^d,e   Raffel, Thomas R ^f   Rohr, Jason R ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF TAMPA   (United States)

^c ALLEGHENY COLLEGE   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f OAKLAND UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BATRACHOCHYTRIUM DENDROBATIDIS ANTIGEN; FUNGUS ANTIGEN; UNCLASSIFIED DRUG;

AMPHIBIAN; DISEASE RESISTANCE; FUNGAL DISEASE; FUNGUS; HOST-PATHOGEN INTERACTION; IMMUNITY; INVASIVE SPECIES; MORTALITY; PATHOGENICITY; POPULATION DECLINE; TAXONOMY; TEMPERATURE EFFECT; WILD POPULATION;

ADAPTIVE IMMUNITY; ANURA; ARTICLE; BATRACHOCHYTRIUM DENDROBATIDIS; CELLULAR IMMUNITY; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FUNGUS EXPOSURE; GENE EXPRESSION; HERD IMMUNITY; HISTOCOMPATIBILITY COMPLEX; HOST PARASITE INTERACTION; HOST RESISTANCE; IMMUNE RESPONSE; INNATE IMMUNITY; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MORTALITY; NATURAL ENEMY; NONHUMAN; PATHOGEN CLEARANCE; PATHOGEN LOAD; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL;

AMPHIBIANS; ANIMALS; ANTIGENS, FUNGAL; CELL PROLIFERATION; CHYTRIDIOMYCOTA; LYMPHOCYTE COUNT; LYMPHOCYTES; MYCOSES; POPULATION DENSITY; SURVIVAL ANALYSIS;

EID: 84904194204     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13491     Document Type: Article

References (30)

1. Fisher, M. C. et al. Emerging fungal threats to animal, plant and ecosystem health. Nature 484, 186-194 (2012).
2. Blehert, D. S. et al. Bat white-nose syndrome: an emerging fungal pathogen? Science 323, 227 (2009).
3. Cameron, S. A. et al. Patterns of widespread decline in North American bumble bees. Proc. Natl Acad. Sci. USA 108, 662-667 (2011).
4. Allender, M. C. et al. Chrysosporium sp. infection in eastern massasauga rattlesnakes. Emerg. Infect. Dis. 17, 2383-2384 (2011).
5. Sexton, A. C. & Howlett, B. J. Parallels in fungal pathogenesis on plant and animal hosts. Eukaryot. Cell 5, 1941-1949 (2006).
6. Stuart, S. N. et al. Status and trends of amphibian declines and extinctions worldwide. Science 306, 1783-1786 (2004).
7. Fites, J. S. et al. The invasive chytrid fungus of amphibians paralyzes lymphocyte responses. Science 342, 366-369 (2013).
8. Rosenblum, E. B. et al. Genome-wide transcriptional response of Silurana (Xenopus) tropicalis to infection with the deadly chytrid fungus. PLoSONE 4, e6494 (2009).
9. Ribas, L. et al. Expression profiling the temperature-dependent amphibian response to infection by Batrachochytrium dendrobatidis. PLoS ONE 4, e8408 (2009).
10. Chivers, D. P. & Smith, R. J. F. Chemical alarm signalling in aquatic predator-prey systems: A review and prospectus. Ecoscience 5, 338-352 (1998).
11. Durrant, W. E.& Dong, X. Systemic acquired resistance. Annu. Rev. Phytopathol. 42, 185-209 (2004).
12. Woodhams, D. C. et al. Mitigating amphibian disease: strategies to maintain wild populations and control chytridiomycosis. Front. Zool. 8, 8 (2011).
13. Briggs, C. J., Knapp, R. A. & Vredenburg, V. T. Enzootic and epizootic dynamics of the chytrid fungal pathogen of amphibians. Proc. Natl Acad. Sci. USA 107, 9695-9700 (2010).
14. Venesky, M. D., Raffel, T. R., McMahon, T. A. & Rohr, J. R. Confronting inconsistencies in the amphibian-chytridiomycosis system: implications for disease management. Biol. Rev. Camb. Philos. Soc. 89, 477-483 (2014).
15. Richmond, J. Q., Savage, A. E., Zamudio, K. R. & Rosenblum, E. B. Toward immunogenetic studies of amphibian chytridiomycosis: linking innate and acquired immunity. Bioscience 59, 311-320 (2009).
16. Rollins-Smith, L. A., Ramsey, J. P., Pask, J. D., Reinert, L. K. & Woodhams, D. C. Amphibian immune defenses against chytridiomycosis: impacts of changing environments. Integr. Comp. Biol. 51, 552-562 (2011).
17. Ramsey, J. P., Reinert, L. K., Harper, L. K., Woodhams, D. C. & Rollins-Smith, L. A. Immune defenses against Batrachochytrium dendrobatidis, a fungus linked to global amphibian declines, in the south african clawed frog, Xenopus laevis. Infect. Immun. 78, 3981-3992 (2010).
18. Savage, A. E. & Zamudio, K. R. MHC genotypes associate with resistance to a frogkilling fungus. Proc. Natl Acad. Sci. USA 108, 16705-16710 (2011).
19. Murphy, P. J., St-Hilaire, S. & Corn, P. S. Temperature, hydric environment, and prior pathogen exposure alter the experimental severity of chytridiomycosis in boreal toads. Dis. Aquat. Organ. 95, 31-42 (2011).
20. Cashins, S. D. et al. Prior infection does not improve survival against theamphibian disease chytridiomycosis. PLoS ONE 8, e56747 (2013).
21. Stice, M. J. & Briggs, C. J. Immunization is ineffective at preventing infection and mortality due to the amphibian chytrid fungus Batrachochytrium dendrobatidis. J. Wildl. Dis. 46, 70-77 (2010).
22. Shaw, S. D. et al. Experimental infection of self-cured Leiopelma archeyi with the amphibian chytrid Batrachochytrium dendrobatidis. Dis. Aquat. Organ. 92, 159-163 (2010).
23. Rohr, J. R., Swan, A., Raffel, T. R. & Hudson, P. J. Parasites, info-disruption, and the ecology of fear. Oecologia 159, 447-454 (2009).
24. Kiesecker, J. M., Skelly, D. K., Beard, K. H. & Preisser, E. Behavioral reduction of infection risk. Proc. Natl Acad. Sci. USA 96, 9165-9168 (1999).
25. Rollins-Smith, L. A., Parsons, S. C. V. & Cohen, N. During frog ontogeny, PHA and Con-A responsiveness of splenocytes precedes that of thymocytes. Immunology 52, 491-500 (1984).
26. Rollins-Smith, L. A. et al. Immune defenses of Xenopus laevis against Batrachochytrium dendrobatidis. Front. Biosci. S1, 68-91 (2009).
27. Pawelec, G., Ehninger, G., Rehbein, A., Schaudt, K. & Jaschonek, K. Comparison of the immunosuppressive activities of the antimycotic agents, intraconazole, fluconazole, ketoconazole and miconazole on human T-cells. Int. J. Immunopharmacol. 13, 299-304 (1991).
28. Venesky, M. D., Mendelson, J. R., Stiling, P., Sears, B. F. & Rohr, J. R. Selecting for tolerance against pathogens and herbivores to enhance success of reintroduction and translocation. Conserv. Biol. 26, 586-592 (2012).
29. McMahon, T. A. et al. Chytrid fungus Batrachochytrium dendrobatidis has nonamphibian hosts and releases chemicals that cause pathology in the absence of infection. Proc. Natl Acad. Sci. USA 110, 210-215 (2013).
30. Hyatt, A. D. et al. Diagnostic assays and sampling protocols for the detection of Batrachochytrium dendrobatidis. Dis. Aquat. Organ. 73, 175-192 (2007).