메뉴 건너뛰기




Volumn 29, Issue 2, 2014, Pages 81-90

The pharmacogenetics of drug metabolizing enzymes in the Lebanese population

Author keywords

CYPs; Drug metabolizing enzymes (DMEs); Lebanon; Pharmacogenetics

Indexed keywords

ABC TRANSPORTER G1; ACENOCOUMAROL; ANTICOAGULANT AGENT; BREAST CANCER RESISTANCE PROTEIN; CALCIFEDIOL; CLOPIDOGREL; COUMARIN ANTICOAGULANT; CYCLOPHOSPHAMIDE; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; DOCETAXEL; DRUG METABOLIZING ENZYME; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE T1; METHOTREXATE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 6; TAMOXIFEN; WARFARIN; CYTOCHROME P450 2B6; DRUG; GLUTATHIONE TRANSFERASE; VITAMIN K EPOXIDE REDUCTASE;

EID: 84904182091     PISSN: 07925077     EISSN: 21910162     Source Type: Journal    
DOI: 10.1515/dmdi-2013-0058     Document Type: Review
Times cited : (11)

References (70)
  • 2
    • 77954926600 scopus 로고    scopus 로고
    • Pharmacogenetics and personalized medicine: The future for drug prescribing
    • Mitri A, Esmerian MO, Simaan JA, Sabra R, Zghein NK. Pharmacogenetics and personalized medicine: the future for drug prescribing. J Med Liban 2010;58:101-4.
    • (2010) J Med Liban , vol.58 , pp. 101-104
    • Mitri, A.1    Esmerian, M.O.2    Simaan, J.A.3    Sabra, R.4    Zghein, N.K.5
  • 5
    • 84879101410 scopus 로고    scopus 로고
    • Genetic polymorphisms of cyp2e1 gst and nat2 enzymes are not associated with risk of breast cancer in a sample of lebanese women
    • Zgheib NK, Shamseddine AA, Geryess E, Tfayli A, Bazarbachi A, Salem Z, et al. Genetic polymorphisms of CYP2E1, GST, and NAT2 enzymes are not associated with risk of breast cancer in a sample of Lebanese women. Mutat Res 2013; 747-748:40-7.
    • (2013) Mutat Res , vol.747-748 , pp. 40-47
    • Zgheib, N.K.1    Shamseddine, A.A.2    Geryess, E.3    Tfayli, A.4    Bazarbachi, A.5    Salem, Z.6
  • 7
    • 0034091891 scopus 로고    scopus 로고
    • Arylamine N-acetyltransferase 1 (NAT1) genotypes in a Lebanese population
    • DOI 10.1097/00008571-200002000-00010
    • Dhaini HR, Levy GN. Arylamine N-Acetyltransferase 1 (NAT1) genotypes in a Lebanese population. Pharmacogenetics 2000;10:79-83. (Pubitemid 30142816)
    • (2000) Pharmacogenetics , vol.10 , Issue.1 , pp. 79-83
    • Dhaini, H.R.1    Levy, G.N.2
  • 8
    • 84866246303 scopus 로고    scopus 로고
    • N-Acetyltransferase 1 (nat1) genotype: A risk factor for urinary bladder cancer in a lebanese population
    • Yassine IA, Kobeissi L, Jabbour ME, Dhaini HR. N-Acetyltransferase 1 (NAT1) genotype: a risk factor for urinary bladder cancer in a Lebanese population. J Oncol 2012;2012:512976.
    • (2012) J Oncol , vol.2012 , pp. 512976
    • Yassine, I.A.1    Kobeissi, L.2    Jabbour, M.E.3    Dhaini, H.R.4
  • 9
    • 79959214377 scopus 로고    scopus 로고
    • Cyp1a1 cyp2e1 and gstm1 gene polymorphisms and susceptibility to colorectal and gastric cancer among lebanese
    • Darazy M, Balbaa M, Mugharbil A, Saeed H, Sidani H, Abdel-Razzak Z. CYP1A1, CYP2E1, and GSTM1 gene polymorphisms and susceptibility to colorectal and gastric cancer among Lebanese. Genet Test Mol Biomark 2011;15:423-9.
    • (2011) Genet Test Mol Biomark , vol.15 , pp. 423-429
    • Darazy, M.1    Balbaa, M.2    Mugharbil, A.3    Saeed, H.4    Sidani, H.5    Abdel-Razzak, Z.6
  • 10
    • 80955123991 scopus 로고    scopus 로고
    • Genetic polymorphism of the glutathione s-transferase m1 and t1 genes in three distinct arab populations
    • Salem AH, Yaqoob A, Ali M, Handu S, Fadel R, Abu-Hijleh M, et al. Genetic polymorphism of the glutathione S-transferase M1 and T1 genes in three distinct Arab populations. Dis Markers 2011;31:311-6.
    • (2011) Dis Markers , vol.31 , pp. 311-316
    • Salem, A.H.1    Yaqoob, A.2    Ali, M.3    Handu, S.4    Fadel, R.5    Abu-Hijleh, M.6
  • 11
  • 13
    • 0035987174 scopus 로고    scopus 로고
    • Allele and genotype frequencies of polymorphic cytochromes P450 (CYP2C9, CYP2C19, CYP2E1) and dihydropyrimidine dehydrogenase (DPYD) in the Egyptian population
    • DOI 10.1046/j.1365-2125.2002.01604.x
    • Ismail Hamdy S, Hiratsuka M, Narahara K, El-Enany M, Moursi N, Salah-Eldin Ahmed M, et al. Allele and genotype frequencies of polymorphic cytochromes P450 (CYP2C9, CYP2C19, CYP2E1) and dihydropyrimidine dehydrogenase (DPYD) in the Egyptian population. Br J Clin Pharmacol 2002;53:596-603. (Pubitemid 34621785)
    • (2002) British Journal of Clinical Pharmacology , vol.53 , Issue.6 , pp. 596-603
    • Hamdy, S.I.1    Hiratsuka, M.2    Narahara, K.3    El-Enany, M.4    Moursi, N.5    Ahmed, M.S.-E.6    Mizugaki, M.7
  • 14
    • 84866854104 scopus 로고    scopus 로고
    • Evaluation of glutathione s-transferase p1 genetic variants affecting type-2 diabetes susceptibility and glycemic control
    • Amer MA, Ghattas MH, Abo-Elmatty DM, Abou-El-Ela SH. Evaluation of glutathione S-transferase P1 genetic variants affecting type-2 diabetes susceptibility and glycemic control. Arch Med Sci 2012;8:631-6.
    • (2012) Arch Med Sci , vol.8 , pp. 631-636
    • Amer, M.A.1    Ghattas, M.H.2    Abo-Elmatty, D.M.3    Abou-El-Ela, S.H.4
  • 16
    • 84871653536 scopus 로고    scopus 로고
    • Synergism of cyp2r1 and cyp27b1 polymorphisms and susceptibility to type 1 diabetes in egyptian children
    • Hussein AG, Mohamed RH, Alghobashy AA. Synergism of CYP2R1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Egyptian children. Cell Immunol 2012;279:42-5.
    • (2012) Cell Immunol , vol.279 , pp. 42-45
    • Hussein, A.G.1    Mohamed, R.H.2    Alghobashy, A.A.3
  • 17
    • 84055216947 scopus 로고    scopus 로고
    • Identification of new alleles and the determination of alleles and genotypes frequencies at the cyp2d6 gene in emiratis
    • Qumsieh R, Ali B, Abdulrazzaq Y, Osman O, Akawi N, Bastaki S. Identification of New alleles and the determination of alleles and genotypes frequencies at the CYP2D6 gene in emiratis. PLoS One 2011;6:e28943.
    • (2011) PLoS One , vol.6
    • Qumsieh, R.1    Ali, B.2    Abdulrazzaq, Y.3    Osman, O.4    Akawi, N.5    Bastaki, S.6
  • 18
    • 84864630955 scopus 로고    scopus 로고
    • Investigate the role of glutathione s transferase (gst) polymorphism in development of hypertension in uae population
    • Hussain K, Salah N, Hussain S, Hussain S. Investigate the role of glutathione S transferase (GST) polymorphism in development of hypertension in UAE population. Iran Red Crescent Med J 2012;14:479-82.
    • (2012) Iran Red Crescent Med J , vol.14 , pp. 479-482
    • Hussain, K.1    Salah, N.2    Hussain, S.3    Hussain, S.4
  • 20
    • 77957679804 scopus 로고    scopus 로고
    • N-Acetyltransferase-2 (nat2) genotype frequency among jordanian volunteers
    • Jarrar YB, Ismail S, Irshaid YM. N-Acetyltransferase-2 (NAT2) genotype frequency among Jordanian volunteers. Int J Clin Pharmacol Ther 2010;48:688-94.
    • (2010) Int J Clin Pharmacol Ther , vol.48 , pp. 688-694
    • Jarrar, Y.B.1    Ismail, S.2    Irshaid, Y.M.3
  • 21
    • 84868581720 scopus 로고    scopus 로고
    • Allele and genotype frequencies of the polymorphic cytochrome p450 genes (cyp1a1, cyp3a4, cyp3a5, cyp2c9 and cyp2c19) in the jordanian population
    • Yousef AM, Bulatova N, Newman W, Hakooz N, Ismail S, Qusa H, et al. Allele and genotype frequencies of the polymorphic cytochrome P450 genes (CYP1A1, CYP3A4, CYP3A5, CYP2C9 and CYP2C19) in the Jordanian population. Mol Biol Rep 2012;39:9423-33.
    • (2012) Mol Biol Rep , vol.39 , pp. 9423-9433
    • Yousef, A.M.1    Bulatova, N.2    Newman, W.3    Hakooz, N.4    Ismail, S.5    Qusa, H.6
  • 22
    • 84867521268 scopus 로고    scopus 로고
    • Frequency of certain singlenucleotide polymorphisms and duplication of cyp2d6 in the jordanian population
    • Zihlif M, Imraish A, Irshaid YM. Frequency of certain singlenucleotide polymorphisms and duplication of CYP2D6 in the Jordanian population. Genet Test Mol Biomark 2012;16:1201-5.
    • (2012) Genet Test Mol Biomark , vol.16 , pp. 1201-1205
    • Zihlif, M.1    Imraish, A.2    Irshaid, Y.M.3
  • 23
    • 84874084150 scopus 로고    scopus 로고
    • The gstp1 ile105val polymorphism is not associated with susceptibility to colorectal cancer
    • Khabaz MN. The GSTP1 Ile105Val polymorphism is not associated with susceptibility to colorectal cancer. Asian Pac J Cancer Prev 2012;13:2949-53.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 2949-2953
    • Khabaz, M.N.1
  • 24
    • 84855834627 scopus 로고    scopus 로고
    • Cyp1ai, glutathione s-transferase gene polymorphisms and risk of polycythemia vera
    • Naffa RG, Awidi AS, Yousef AM, Ismail SI. CYP1AI, glutathione S-transferase gene polymorphisms and risk of Polycythemia vera. Cancer Epidemiol 2012;36:68-72.
    • (2012) Cancer Epidemiol , vol.36 , pp. 68-72
    • Naffa, R.G.1    Awidi, A.S.2    Yousef, A.M.3    Ismail, S.I.4
  • 26
    • 77958007990 scopus 로고    scopus 로고
    • Investigation of allele and genotype frequencies of cyp2c9, cyp2c19 and vkorc1 in iran
    • Azarpira N, Namazi S, Hendijani F, Banan M, Darai M. Investigation of allele and genotype frequencies of CYP2C9, CYP2C19 and VKORC1 in Iran. Pharmacol Rep 2010;62:740-6.
    • (2010) Pharmacol Rep , vol.62 , pp. 740-746
    • Azarpira, N.1    Namazi, S.2    Hendijani, F.3    Banan, M.4    Darai, M.5
  • 27
    • 81755171121 scopus 로고    scopus 로고
    • Frequencies of three cyp2d6 nonfunctional alleles (cyp2d63, 4, and 6) within an iranian population (mazandaran
    • Hashemi-Soteh SM, Sarzare F, Merat F, Salehifar E, Shiran MR. Frequencies of three CYP2D6 nonfunctional alleles (CYP2D63, 4, and 6) within an Iranian population (Mazandaran). Genet Test Mol Biomark 2011;15:821-5.
    • (2011) Genet Test Mol Biomark , vol.15 , pp. 821-825
    • Hashemi-Soteh, S.M.1    Sarzare, F.2    Merat, F.3    Salehifar, E.4    Shiran, M.R.5
  • 29
    • 85027920413 scopus 로고    scopus 로고
    • Study of the association between glutathione s-transferase (gstm1, gstt1, gstp1) polymorphisms with type ii diabetes mellitus in southern of iran
    • Moasser E, Kazemi-Nezhad SR, Saadat M, Azarpira N. Study of the association between glutathione S-transferase (GSTM1, GSTT1, GSTP1) polymorphisms with type II diabetes mellitus in southern of Iran. Mol Biol Rep 2012;39:10187-92.
    • (2012) Mol Biol Rep , vol.39 , pp. 10187-10192
    • Moasser, E.1    Kazemi-Nezhad, S.R.2    Saadat, M.3    Azarpira, N.4
  • 30
    • 33845765706 scopus 로고    scopus 로고
    • Frequency of CYP2C9 genotypes among Omani patients receiving warfarin and its correlation with warfarin dose
    • DOI 10.1159/000096279
    • Tanira MO, Al-Mukhaini MK, Al-Hinai AT, Al Balushi Ka, Ahmed IS. Frequency of CYP2C9 genotypes among Omani patients receiving warfarin and its correlation with warfarin dose. Community Genet 2007;10:32-7. (Pubitemid 46005799)
    • (2007) Community Genetics , vol.10 , Issue.1 , pp. 32-37
    • Tanira, M.O.1    Al-Mukhaini, M.K.2    Al-Hinai, A.T.3    Al Balushi, K.A.4    Ahmed, I.S.5
  • 32
    • 84882575078 scopus 로고    scopus 로고
    • Cytochrome P450 1A1, 2E1 and GSTM1 gene polymorphisms and susceptibility to colorectal cancer in the Saudi Population
    • Saeed H, Alanazi M, Nounou H, Shalaby M, Semlali A, Azzam N, et al. Cytochrome P450 1A1, 2E1 and GSTM1 gene polymorphisms and susceptibility to colorectal cancer in the Saudi Population. Asian Pac J Cancer Prev 2013;14:3761-68.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 3761-3768
    • Saeed, H.1    Alanazi, M.2    Nounou, H.3    Shalaby, M.4    Semlali, A.5    Azzam, N.6
  • 33
    • 84876557306 scopus 로고    scopus 로고
    • Genotyping of cyp2c9 and vkorc1 in the arabic population of al-Ahsa, saudi arabia
    • Alzahrani A, Ragia G, Hanieh H, Manolopoulos V. Genotyping of CYP2C9 and VKORC1 in the Arabic Population of Al-Ahsa, Saudi Arabia. Biomed Res Int 2013;2013:315980.
    • (2013) Biomed Res Int , vol.2013 , pp. 315980
    • Alzahrani, A.1    Ragia, G.2    Hanieh, H.3    Manolopoulos, V.4
  • 34
    • 0030904031 scopus 로고    scopus 로고
    • Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations
    • DOI 10.1097/00008571-199702000-00008
    • Goldstein JA, Ishizaki T, Chiba K, de Morais SM, Bell D, Krahn PM, et al. Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations. Pharmacogenetics 1997;7:59-64. (Pubitemid 27153320)
    • (1997) Pharmacogenetics , vol.7 , Issue.1 , pp. 59-64
    • Goldstein, J.A.1    Ishizaki, T.2    Chiba, K.3    De Morais, S.M.F.4    Bell, D.5    Krahn, P.M.6    Price Evans, D.A.7
  • 38
    • 84878348527 scopus 로고    scopus 로고
    • Genetic polymorphisms of nqo1, cyp1a1 and tpmt and susceptibility to acute lymphoblastic leukemia in a tunisian population
    • Ouerhani S, Cherif N, Bahri I, Safra I, Menif S, Abbes S. Genetic polymorphisms of NQO1, CYP1A1 and TPMT and susceptibility to acute lymphoblastic leukemia in a Tunisian population. Mol Biol Rep 2013;40:1307-14.
    • (2013) Mol Biol Rep , vol.40 , pp. 1307-1314
    • Ouerhani, S.1    Cherif, N.2    Bahri, I.3    Safra, I.4    Menif, S.5    Abbes, S.6
  • 39
    • 85027958881 scopus 로고    scopus 로고
    • The prevalence of vkorc1 1639 g > a and cyp2c9 2 3 genotypes in patients that requiring anticoagulant therapy in turkish population
    • Silan C, Tamer Dogan O, Silan F, Mutlu Kukulguven F, Asgun H, Ozdemir S, et al. The prevalence of VKORC1 1639 G > A and CYP2C9 2 3 genotypes in patients that requiring anticoagulant therapy in Turkish population. Mol Biol Rep 2012;39:11017-22.
    • (2012) Mol Biol Rep , vol.39 , pp. 11017-11022
    • Silan, C.1    Tamer Dogan, O.2    Silan, F.3    Mutlu Kukulguven, F.4    Asgun, H.5    Ozdemir, S.6
  • 40
    • 84865622456 scopus 로고    scopus 로고
    • The frequencies of mutated alleles of cyp2d6 gene in a turkish population
    • Serin A, Canan H, Alper B, Gulmen M. The frequencies of mutated alleles of CYP2D6 gene in a Turkish population. Forensic Sci Int 2012;222:332-4.
    • (2012) Forensic Sci Int , vol.222 , pp. 332-334
    • Serin, A.1    Canan, H.2    Alper, B.3    Gulmen, M.4
  • 41
    • 84863861352 scopus 로고    scopus 로고
    • The role of gstm1, gstt1, gstp1, and ogg1 polymorphisms in type 2 diabetes mellitus risk: A case-control study in a turkish population
    • Gönül N, Kadioglu E, Kocabas NA, Ozkaya M, Karakaya AE, Karahalil B. The role of GSTM1, GSTT1, GSTP1, and OGG1 polymorphisms in type 2 diabetes mellitus risk: a case-control study in a Turkish population. Gene 2012;505:121-7.
    • (2012) Gene , vol.505 , pp. 121-127
    • Gönül, N.1    Kadioglu, E.2    Kocabas, N.A.3    Ozkaya, M.4    Karakaya, A.E.5    Karahalil, B.6
  • 42
    • 34547897290 scopus 로고    scopus 로고
    • Genotype and allele frequencies of polymorphic CYP2E1 in the Turkish population
    • DOI 10.1007/s00204-007-0200-y
    • Ulusoy G, Arinç E, Adali O. Genotype and allele frequencies of polymorphic CYP2E1 in the Turkish population. Arch Toxicol 2007;81:711-8. (Pubitemid 47512602)
    • (2007) Archives of Toxicology , vol.81 , Issue.10 , pp. 711-718
    • Ulusoy, G.1    Arinc, E.2    Adali, O.3
  • 43
    • 0030789075 scopus 로고    scopus 로고
    • Arylamine N-acetyltransferase (NAT2) genotypes in a Turkish population
    • DOI 10.1097/00008571-199708000-00008
    • Aynacioglu AS, Cascorbi I, Mrozikiewicz PM, Roots I. Arylamine N-Acetyltransferase (NAT2) genotypes in a Turkish population. Pharmacogenetics 1997;7:327-31. (Pubitemid 27356933)
    • (1997) Pharmacogenetics , vol.7 , Issue.4 , pp. 327-331
    • Aynacioglu, A.S.1    Cascorbi, I.2    Mrozikiewicz, P.M.3    Roots, I.4
  • 45
    • 84904196715 scopus 로고    scopus 로고
    • Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine. Available at
    • Database of Single Nucleotide Polymorphisms (dbSNP). Bethesda (MD): National Center for Biotechnology Information, National Library of Medicine. Available at: http://www.ncbi.nlm. nih.gov/SNP/.
  • 46
    • 0029163589 scopus 로고
    • Arylamine n-Acetyltransferase (nat2) mutations and their allelic linkage in unrelated caucasian individuals: Correlation with phenotypic activity
    • Cascorbi I, Drakoulis N, Brockmöller J, Maurer A, Sperling K, Roots I. Arylamine N-Acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity. Am J Hum Genet 1995;57:581-92.
    • (1995) Am J Hum Genet , vol.57 , pp. 581-592
    • Cascorbi, I.1    Drakoulis, N.2    Brockmöller, J.3    Maurer, A.4    Sperling, K.5    Roots, I.6
  • 48
    • 80053270853 scopus 로고    scopus 로고
    • Influence of cyp2c9 and vkorc1 polymorphisms on warfarin and acenocoumarol in a sample of lebanese people
    • Esmerian M, Mitri Z, Habbal M, Geryess E, Zaatari G, Alam S, et al. Influence of CYP2C9 and VKORC1 polymorphisms on warfarin and acenocoumarol in a sample of Lebanese people. J Clin Pharmacol 2011;51:1418-28.
    • (2011) J Clin Pharmacol , vol.51 , pp. 1418-1428
    • Esmerian, M.1    Mitri, Z.2    Habbal, M.3    Geryess, E.4    Zaatari, G.5    Alam, S.6
  • 49
    • 84880570065 scopus 로고    scopus 로고
    • Cyp2c19 genetic polymorphism, rabeprazole and esomeprazole have no effect on the antiplatelet action of clopidogrel
    • El-Halabi M, Zgheib NK, Mansour N, Malli A, Ghaith O, Mahfouz R, et al. CYP2C19 genetic polymorphism, rabeprazole and esomeprazole have no effect on the antiplatelet action of clopidogrel. J Cardiovasc Pharmacol 2013;62:41-9.
    • (2013) J Cardiovasc Pharmacol , vol.62 , pp. 41-49
    • El-Halabi, M.1    Zgheib, N.K.2    Mansour, N.3    Malli, A.4    Ghaith, O.5    Mahfouz, R.6
  • 51
    • 77954940821 scopus 로고    scopus 로고
    • Cytochrome p4502e1 (cyp2e1) genetic polymorphisms in a lebanese population: Frequency distribution and association with morbid diseases
    • Zgheib NK, Mitri Z, Geryess E, Noutsi P. Cytochrome P4502E1 (CYP2E1) genetic polymorphisms in a Lebanese population: frequency distribution and association with morbid diseases. Genet Test Mol Biomarkers 2010;14:393-7.
    • (2010) Genet Test Mol Biomarkers , vol.14 , pp. 393-397
    • Zgheib, N.K.1    Mitri, Z.2    Geryess, E.3    Noutsi, P.4
  • 52
    • 84904152885 scopus 로고    scopus 로고
    • Cyp2r1 genetic polymorphisms are associated with lower 25-hydroxy vitamin d levels in lebanese subjects [abstract]
    • Zgheib NK, Arabi A, Mahfouz R, El-hajj Fuleihan G. CYP2R1 genetic polymorphisms are associated with lower 25-hydroxy vitamin D levels in Lebanese subjects [abstract]. Presented at: 11th EACPT Congress 2013:28-31.
    • (2013) Presented at: 11th EACPT Congress , pp. 28-31
    • Zgheib, N.K.1    Arabi, A.2    Mahfouz, R.3    El-hajj Fuleihan, G.4
  • 53
    • 80052962391 scopus 로고    scopus 로고
    • Clinical pharmacogenetics implementation consortium guidelines for cyp2c9 and vkorc1 genotypes and warfarin dosing
    • Johnson JA, Gong L, Whirl-Carrillo M, Gage BF, Scott SA, Stein CM, et al. Clinical pharmacogenetics implementation consortium guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing. Clin Pharmacol Ther 2011;90:625-9.
    • (2011) Clin Pharmacol Ther , vol.90 , pp. 625-629
    • Johnson, J.A.1    Gong, L.2    Whirl-Carrillo, M.3    Gage, B.F.4    Scott, S.A.5    Stein, C.M.6
  • 54
    • 84902366989 scopus 로고    scopus 로고
    • Improved accuracy of anticoagulant dose prediction using a pharmacogenetic and artificial neural network based method
    • Dec 3. [Epub ahead of print]
    • Isma'eel H, Sakr G, Habib R, Almedawar M, Zgheib NK, Elhajj I. Improved accuracy of anticoagulant dose prediction using a pharmacogenetic and artificial neural network based method. Eur J Clin Pharmacol 2013 Dec 3. [Epub ahead of print].
    • (2013) Eur J Clin Pharmacol
    • Isma'eel, H.1    Sakr, G.2    Habib, R.3    Almedawar, M.4    Zgheib, N.K.5    Elhajj, I.6
  • 55
    • 84904192208 scopus 로고    scopus 로고
    • US Food Drug Administration. Update to the labeling of Clopidogrel Bisulfate (marketed as Plavix) to alert healthcare professionals about a drug interaction with omeprazole (marketed as Prilosec and Prilosec OTC). 2011. Available at
    • US Food and Drug Administration. Update to the labeling of Clopidogrel Bisulfate (marketed as Plavix) to alert healthcare professionals about a drug interaction with omeprazole (marketed as Prilosec and Prilosec OTC). 2011. Available at: http://www.accessdata.fda.gov/drugsatfda-docs/label/2011/ 020839s055lbl.pdf.
  • 56
    • 80053954075 scopus 로고    scopus 로고
    • Pharmacogenomics of clopidogrel: Evidence and perspectives
    • Yin T, Miyata T. Pharmacogenomics of clopidogrel: evidence and perspectives. Thromb Res 2011;128:307-16.
    • (2011) Thromb Res , vol.128 , pp. 307-316
    • Yin, T.1    Miyata, T.2
  • 57
    • 77956913721 scopus 로고    scopus 로고
    • Hypovitaminosis d in developing countries -prevalence, risk factors and outcomes
    • Arabi A, El Rassi R, El-Hajj Fuleihan G. Hypovitaminosis D in developing countries -prevalence, risk factors and outcomes. Nat Rev Endocrinol 2010;6:550-61.
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 550-561
    • Arabi, A.1    El Rassi, R.2    El-Hajj Fuleihan, G.3
  • 58
    • 84880589033 scopus 로고    scopus 로고
    • Vitamin d -from essentiality to functionality
    • Bischoff-Ferrari H. Vitamin D -from essentiality to functionality. Int J Vitam Nutr Res 2012;82:321-6.
    • (2012) Int J Vitam Nutr Res , vol.82 , pp. 321-326
    • Bischoff-Ferrari, H.1
  • 59
    • 84904185888 scopus 로고    scopus 로고
    • The role of pharmacogenetics in the treatment of lebanese patients with childhood acute lymphoblastic leukemia [abstract]
    • Zgheib NK, Akra M, Aridi C, Saab R, Abboud M, Mahfouz R, et al. The role of pharmacogenetics in the treatment of Lebanese patients with childhood acute lymphoblastic leukemia [abstract]. Presented at: 44th SIOP Congress; 2012:5-8.
    • (2012) Presented At: 44th SIOP Congress , pp. 5-8
    • Zgheib, N.K.1    Akra, M.2    Aridi, C.3    Saab, R.4    Abboud, M.5    Mahfouz, R.6
  • 60
    • 77949539805 scopus 로고    scopus 로고
    • Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide
    • Bray J, Sludden J, Griffin MJ, Cole M, Verrill M, Jamieson D, et al. Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide. Br J Cancer 2010;102:1003-9.
    • (2010) Br J Cancer , vol.102 , pp. 1003-1009
    • Bray, J.1    Sludden, J.2    Griffin, M.J.3    Cole, M.4    Verrill, M.5    Jamieson, D.6
  • 61
    • 84860294388 scopus 로고    scopus 로고
    • Relationship of drug metabolizing enzyme genotype to plasma levels as well as myelotoxicity of cyclophosphamide in breast cancer patients
    • Afsar NA, Ufer M, Haenisch S, Remmler C, Mateen A, Usman A, et al. Relationship of drug metabolizing enzyme genotype to plasma levels as well as myelotoxicity of cyclophosphamide in breast cancer patients. Eur J Clin Pharmacol 2012;68:389-95.
    • (2012) Eur J Clin Pharmacol , vol.68 , pp. 389-395
    • Afsar, N.A.1    Ufer, M.2    Haenisch, S.3    Remmler, C.4    Mateen, A.5    Usman, A.6
  • 62
    • 70349929431 scopus 로고    scopus 로고
    • Association between cyp2d6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen
    • Schroth W, Goetz MP, Hamann U, Fasching PA, Schmidt M, Winter S, et al. Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen. J Am Med Assoc 2009;302:1429-36.
    • (2009) J Am Med Assoc , vol.302 , pp. 1429-1436
    • Schroth, W.1    Goetz, M.P.2    Hamann, U.3    Fasching, P.A.4    Schmidt, M.5    Winter, S.6
  • 65
    • 84880106256 scopus 로고    scopus 로고
    • Pharmacogenomics variation in drug metabolizing enzymes and transporters in relation to docetaxel toxicity in lebanese breast cancer patients: Paving the way for omics in low and middle income countries
    • Awada Z, Haider S, Tfayli A, Bazarbachi A, El-Saghir NS, Salem Z, et al. Pharmacogenomics variation in drug metabolizing enzymes and transporters in relation to docetaxel toxicity in Lebanese breast cancer patients: paving the way for OMICs in low and middle income countries. OMICS 2013;17: 353-67.
    • (2013) OMICS , vol.17 , pp. 353-367
    • Awada, Z.1    Haider, S.2    Tfayli, A.3    Bazarbachi, A.4    El-Saghir, N.S.5    Salem, Z.6
  • 66
    • 77955877789 scopus 로고    scopus 로고
    • Education may improve the underutilization of genetic services by middle eastern primary care practitioners
    • Antoun J, Zgheib NK, Ashkar K. Education may improve the underutilization of genetic services by Middle Eastern primary care practitioners. Genet Test Mol Biomark 2010;14:447-54.
    • (2010) Genet Test Mol Biomark , vol.14 , pp. 447-454
    • Antoun, J.1    Zgheib, N.K.2    Ashkar, K.3
  • 67
    • 79957802841 scopus 로고    scopus 로고
    • Attitudes of health care professionals toward pharmacogenetic testing
    • Zgheib NK, Arawi T, Mahfouz RA, Sabra R. Attitudes of health care professionals toward pharmacogenetic testing. Mol Diagn Ther 2011;15:115-22.
    • (2011) Mol Diagn Ther , vol.15 , pp. 115-122
    • Zgheib, N.K.1    Arawi, T.2    Mahfouz, R.A.3    Sabra, R.4
  • 68
    • 79960815787 scopus 로고    scopus 로고
    • Clinical implementation of pharmacogenetics: A non-representative explorative survey to participants of worldpharma 2010
    • Ghaddar F, Cascorbi I, Zgheib NK. Clinical implementation of pharmacogenetics: a non-representative explorative survey to participants of WorldPharma 2010. Pharmacogenomics 2011;12:1051-9.
    • (2011) Pharmacogenomics , vol.12 , pp. 1051-1059
    • Ghaddar, F.1    Cascorbi, I.2    Zgheib, N.K.3
  • 70
    • 79951809825 scopus 로고    scopus 로고
    • Cpic: Clinical pharmacogenetics implementation consortium of the pharmacogenomics research network
    • Relling MV, Klein TE. CPIC: Clinical pharmacogenetics implementation consortium of the pharmacogenomics research network. Clin Pharmacol Ther 2011;89:464-7.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 464-467
    • Relling, M.V.1    Klein, T.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.