Lymphopenia association with gross tumor volume and lung V5 and its effects on non-small cell lung cancer patient outcomes

International Journal of Radiation Oncology Biology Physics

Volumn 89, Issue 5, 2014, Pages 1084-1091

  Tang, Chad ^a   Liao, Zhongxing ^a   Gomez, Daniel ^a   Levy, Lawrence ^a   Zhuang, Yan ^a   Gebremichael, Rediet A ^a   Hong, David S ^a   Komaki, Ritsuko ^a   Welsh, James W ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTHERAPY; DISEASES; FAULT TOLERANT COMPUTER SYSTEMS; LYMPHOCYTES; MULTIVARIANT ANALYSIS; NATURAL LANGUAGE PROCESSING SYSTEMS; RADIOTHERAPY; REGRESSION ANALYSIS; TUMORS;

CONCURRENT CHEMOTHERAPY; COX REGRESSION ANALYSIS; DOSE-VOLUME HISTOGRAMS; KAPLAN-MEIER ANALYSIS; MULTI VARIATE ANALYSIS; MULTIVARIATE REGRESSION; NON SMALL CELL LUNG CANCER; SPEARMAN CORRELATION COEFFICIENTS;

BIOLOGICAL ORGANS;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CLINICAL ASSESSMENT; CORRELATIONAL STUDY; DISEASE ASSOCIATION; EVENT FREE SURVIVAL; FEMALE; FOLLOW UP; HISTOGRAM; HUMAN; LUNG NON SMALL CELL CANCER; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; MONOCYTE; MULTIMODALITY CANCER THERAPY; NEUTROPHIL; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; TUMOR VOLUME;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; LUNG; LUNG NEOPLASMS; LYMPHOPENIA; MALE; MIDDLE AGED; RADIOTHERAPY DOSAGE; REGRESSION ANALYSIS; TREATMENT OUTCOME; TUMOR BURDEN;

EID: 84904098535     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2014.04.025     Document Type: Article

References (24)

1. S. Demaria, N. Kawashima, and A.M. Yang et al. Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer Clin Cancer Res 11 2005 728 734
2. P. Sansoni, A. Cossarizza, and V. Brianti et al. Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians Blood 82 1993 2767 2773
3. J. Campian, G. Sarai, and X. Ye et al. The association between severe treatment-related lymphopenia and progression free survival in patients with newly diagnosed squamous cell head and neck cancer Head Neck 2013
4. J.L. Campian, X. Ye, and M. Brock et al. Treatment-related lymphopenia in patients with stage III non-small-cell lung cancer Cancer Invest 31 2013 183 188
5. K.E. Stanley Prognostic factors for survival in patients with inoperable lung cancer J Natl Cancer Inst 65 1980 25 32
6. S.A. Grossman, X. Ye, and G. Lesser et al. Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide Clin Cancer Res 17 2011 5473 5480
7. S.C. Formenti, and S. Demaria Combining radiotherapy and cancer immunotherapy: A paradigm shift J Natl Cancer Inst 105 2013 256 265
8. K.S. Sellins, and J.J. Cohen Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes J Immunol 139 1987 3199 3206
9. J.A. Stratton, P.E. Byfield, and J.E. Byfield et al. A comparison of the acute effects of radiation therapy, including or excluding the thymus, on the lymphocyte subpopulations of cancer patients J Clin Invest 56 1975 88 97
10. O.A. Trowell The sensitivity of lymphocytes to ionising radiation J Pathol Bacteriol 64 1952 687 704
11. S. Yovino, L. Kleinberg, and S.A. Grossman et al. The etiology of treatment-related lymphopenia in patients with malignant gliomas: Modeling radiation dose to circulating lymphocytes explains clinical observations and suggests methods of modifying the impact of radiation on immune cells Cancer Invest 31 2013 140 144
12. S. Yoshida, M. Matsui, and Y. Shirouzu et al. Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer Ann Surg 227 1998 485 491
13. N. Kobayashi, S. Usui, and S. Kikuchi et al. Preoperative lymphocyte count is an independent prognostic factor in node-negative non-small cell lung cancer Lung Cancer 75 2012 223 227
14. M.J. McCoy, R.A. Lake, and R.G. van der Most et al. Post-chemotherapy T-cell recovery is a marker of improved survival in patients with advanced thoracic malignancies Br J Cancer 107 2012 1107 1115
15. A. Vigano, E. Bruera, and G.S. Jhangri et al. Clinical survival predictors in patients with advanced cancer Arch Intern Med 160 2000 861 868
16. Y. Lee, S.L. Auh, and Y. Wang et al. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment Blood 114 2009 589 595
17. J.D. Brody, W.Z. Ai, and D.K. Czerwinski et al. In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: A phase I/II study J Clin Oncol 28 2010 4324 4332
18. S.K. Seung, B.D. Curti, and M. Crittenden et al. Phase 1 study of stereotactic body radiotherapy and interleukin-2 - tumor and immunological responses Sci Transl Med 4 2012 137 174
19. Y.H. Kim, D. Gratzinger, and C. Harrison et al. In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: A phase 1/2 study Blood 119 2012 355 363
20. M.A. Postow, M.K. Callahan, and C.A. Barker et al. Immunologic correlates of the abscopal effect in a patient with melanoma N Engl J Med 366 2012 925 931
21. S.M. Hiniker, D.S. Chen, and S. Reddy et al. A systemic complete response of metastatic melanoma to local radiation and immunotherapy Transl Oncol 5 2012 404 407
22. M.G. Ruocco, K.A. Pilones, and N. Kawashima et al. Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects J Clin Invest 122 2012 3718 3730
23. C. Menard, F. Ghiringhelli, and S. Roux et al. Ctla-4 blockade confers lymphocyte resistance to regulatory T-cells in advanced melanoma: Surrogate marker of efficacy of tremelimumab? Clin Cancer Res 14 2008 5242 5249
24. S.M. Hiniker, D.S. Chen, and S.J. Knox Abscopal effect in a patient with melanoma N Engl J Med 366 2012 2035 2036 2035; author reply