Serotonin syndrome in the intensive care unit: Clinical presentations and precipitating medications

Neurocritical Care

Volumn 21, Issue 1, 2014, Pages 108-113

  Pedavally, Swetha ^a   Fugate, Jennifer E ^a   Rabinstein, Alejandro A ^a  

^a MAYO CLINIC   (United States)

Author keywords

Antidepressants; Intensive care unit; Neurotoxicity; Opioids; Serotonin syndrome

Indexed keywords

AMPHETAMINE; BUSPIRONE; CITALOPRAM; CLOMIPRAMINE; CYPROHEPTADINE; DULOXETINE; ESCITALOPRAM; FENTANYL; FLUOXETINE; GRANISETRON; LITHIUM; METHADONE; METHYLENE BLUE; METOCLOPRAMIDE; MIRTAZAPINE; ONDANSETRON; PAROXETINE; PETHIDINE; SERTRALINE; SUMATRIPTAN; TRAMADOL; TRAZODONE; VENLAFAXINE; ANTIEMETIC AGENT; NARCOTIC AGENT; SEROTONIN RECEPTOR AFFECTING AGENT;

ADULT; AGED; AGITATION; ARTICLE; CLINICAL FEATURE; CLONUS; CONTROLLED STUDY; DIAPHORESIS; DISEASE ASSOCIATION; DRUG EXPOSURE; FEMALE; FEVER; HEART FAILURE; HOSPITAL ACQUIRED PNEUMONIA; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; HYPERREFLEXIA; HYPERTENSION; INTENSIVE CARE UNIT; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; MYDRIASIS; MYOCLONUS; OCULAR CLONUS; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RHABDOMYOLYSIS; RIGIDITY; SEROTONIN SYNDROME; TACHYCARDIA; TACHYPNEA; TREATMENT OUTCOME; TREMOR; ADOLESCENT; CHEMICALLY INDUCED; MIDDLE AGED; PATHOPHYSIOLOGY; STATISTICS AND NUMERICAL DATA; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIEMETICS; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; NARCOTICS; SEROTONIN AGENTS; SEROTONIN SYNDROME; YOUNG ADULT;

EID: 84904071511     PISSN: 15416933     EISSN: 15560961     Source Type: Journal    
DOI: 10.1007/s12028-013-9914-2     Document Type: Article

References (23)

1. Sternbach H. The serotonin syndrome. Am J Psychiatry. 1991;148:705-13.
2. Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005;352:112-1112.
3. Isbister GK, Buckley NA. The pathophysiology of serotonin toxicity in animals and humans: implications for diagnosis and treatment. Clin Neuropharmacol. 2005;28:205-14. (Pubitemid 41579617)
4. Dunkley EJ, Isbister GK, Sibbritt D, et al. The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM. 2003;96:635-42. (Pubitemid 37063272)
5. Mills KC. Serotonin syndrome: a clinical update. Crit Care Clin. 1997;13:763-83. (Pubitemid 27432892)
6. Mitchell PB. Drug interactions of clinical significance with selective serotonin reuptake inhibitors. Drug Saf. 1997;17:390-406. (Pubitemid 28017928)
7. Keegan MT, Brown DR, Rabinstein AA. Serotonin syndrome from the interaction of cyclobenzaprine with other serotonergic drugs. Anesth Analg. 2006;103:1466-8. (Pubitemid 44949216)
8. Neuvonen PJ, Pohjola-Sintonen S, Tacke U, Vuori E. Five fatal cases of serotonin syndrome after moclobemide-citalopram or moclobemide-clomipramine overdoses. Lancet. 1993;342:1419. (Pubitemid 23361248)
9. Bronstein AC, Spyker DA, Cantilena LR Jr, et al. 2011 Annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 29th Annual Report. Clin Toxicol (Phila). 2012;50:911-1164.
10. Bienvenu JO, Neufeld KJ, Needham DM. Treatment of four psychiatric emergencies in the intensive care unit. Crit Care Med. 2012;40:2662-70.
11. Nijhawan PK, Katz G, Winter S. Psychiatric illness and the serotonin syndrome: an emerging adverse drug effect leading to intensive care unit admission. Crit Care Med. 1996;24:1086-9. (Pubitemid 26189956)
12. Chechani V. Serotonin syndrome presenting as hypotonic coma and apnea: potentially fatal complications of selective serotonin receptor inhibitor therapy. Crit Care Med. 2002;30:473-6. (Pubitemid 34158136)
13. Torre LE, Menon R, Power BM. Prolonged serotonin toxicity with proserotonergic drugs in the intensive care unit. Crit Care Resusc. 2009;11:272-5.
14. Gollapudy S, Kumar V, Dhamee MS. A case of serotonin syndrome precipitated by fentanyl and ondansetron in a patient receiving paroxetine, duloxetine, and bupropion. J Clin Anesth. 2012;24:251-2.
15. Gillman PK. Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. Br J Anaesth. 2005;95:434-41. (Pubitemid 41418735)
16. Rastogi R, Swarm RA, Patel TA. Case scenario: opioid association with serotonin syndrome: implications to the practitioners. Anesthesiology. 2011;115:1291-8.
17. Denton PH, Borrelli VM, Edwards NV. Dangers of monoamine oxidase inhibitors. BMJ. 1962;2:1752-3.
18. Lawrence KR, Adra M, Gillman PK. Serotonin toxicity associated with the use of linezolid: a review of postmarketing data. Clin Infect Dis. 2006;42:1578-83.
19. Ramsay RR, Dunford C, Gillman PK. Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. Br J Pharmacol. 2007;152:946-51. (Pubitemid 350100489)
20. Graudins A, Stearman A, Chan B. Treatment of the serotonin syndrome with cyproheptadine. J Emerg Med. 1998;16:615-9. (Pubitemid 28348173)
21. McDaniel WW. Serotonin syndrome: early management with cyproheptadine. Ann Pharmacother. 2001;35:870-3. (Pubitemid 32678710)
22. Mackay FJ, Dunn NR, Mann RD. Antidepressants and the serotonin syndrome in general practice. Br J Gen Pract. 1999;49:871-4. (Pubitemid 29504898)
23. Bodner RA, Lynch T, Lewis L, et al. Serotonin syndrome. Neurology. 1995;45:219-23.