Psychiatric illness and the serotonin syndrome: An emerging adverse drug effect leading to intensive care unit admission

Critical Care Medicine

Volumn 24, Issue 6, 1996, Pages 1086-1089

  Nijhawan, Pardeep K ^a   Katz, Gail ^a   Winter, Stephen ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORWALK HOSPITAL   (United States)

Author keywords

alcohol withdrawal; critical illness; drug reaction; psychiatric illness; psychiatry; serotonin; serotonin uptake inhibitors; toxicology

Indexed keywords

ALCOHOL; BUSPIRONE; CLOMIPRAMINE; FLUOXETINE; NITROPRUSSIDE SODIUM; SEROTONIN;

ADULT; ARTICLE; CASE REPORT; CONFUSION; DIAPHORESIS; DIFFERENTIAL DIAGNOSIS; DRUG BLOOD LEVEL; FEVER; HUMAN; HYPERTENSION; INTENSIVE CARE UNIT; MALE; MYOCLONUS; OBSESSION; PRIORITY JOURNAL; RHABDOMYOLYSIS; SYNDROME;

ALCOHOL WITHDRAWAL DELIRIUM; BUSPIRONE; CLOMIPRAMINE; DIAGNOSIS, DIFFERENTIAL; DRUG THERAPY, COMBINATION; FLUOXETINE; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; MYOCLONUS; OBSESSIVE-COMPULSIVE DISORDER; PSYCHOTROPIC DRUGS; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SYNDROME;

EID: 0030012675     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199606000-00034     Document Type: Article

References (28)

1. Hales RE, Yudofsky SC, Talbott JA: Textbook of Psychiatry. Second Edition. Washington, American Psychiatric Press, 1994, pp 721-723
2. Goodman WK, McDougle CJ, Price LH: Pharmacotherapy of obsessive compulsive disorder. J Clin Psychiatry 1992; 53(Suppl):29-37
3. Sternbach H: The serotonin syndrome. Am J Psychiatry 1991; 148:705-713
4. Bodner RA, Lynch T, Lewis L, et al: Serotonin syndrome. Neurology 1995; 45:219-223
5. Wyngaarden JB, Smith LH, Bennett JC: Cecil Textbook of Medicine. 19th Edition. Philadelphia, WB Saunders, 1992, p 47
6. Kline SS, Mauro LS, Scala-Barnett DM, et al: Serotonin syndrome vs. neuroleptic malignant syndrome as a cause of death. Clin Pharm 1989; 8:510-514
7. Rosebush P, Stewart T: A prospective analysis of 24 episodes of neuroleptic syndrome. Am J Psychiatry 1989; 146: 717-725
8. Brennan D, MacManus M, Howe J, et al: Neuroleptic malignant syndrome without neuroleptics. Br J Psychiatry 1988; 152:578-579
9. Thomas JM, Rubin EH: Case report of a toxic reaction from a combination of tryptophan and phenelzine. Am J Psychiatry 1984; 141:281-283
10. Muly EC, McDonald W, Steffens D, et al: Serotonin syndrome produced by a combination of fluoxetine and lithium. Am J Psychiatry 1993; 150:1565
11. Oates JA, Sjoerdsma A: Neurologic effects of tryptophan in patients receiving a monoamine oxidase inhibitor. Neurology 1960; 10:1076-1078
12. Curry SC, Agnone FA, Mills KC: Neurotransmitter principles. In: Goldfrank's Toxicologic Emergencies. Fifth Edition. Goldfrank LR (Ed). East Norwalk, Appleton and Lange, 1994, pp 245
13. Douglas WW: Histamic and 5-hydroxy tryptamine (serotonin) and their antagonists. In: The Pharmacological Basis of Therapeutics. Seventh Edition. Gilman AG, Gilman LS, Rall TW, et al (Eds). New York, Macmillan Publishing Company, 1985, pp 628-633
14. Dubovsky SL: Beyond the serotonin reuptake inhibitors: Rationales for the development of new serotonergic drugs. J Clin Psychiatry 1994; 55:34-44
15. Hjorth S, Carlsson A: Buspirone: Effects on central monoaminergic transmission possible relevance to animal experimental and clinical findings. Eur J Pharmacol 1982; 83:299-303
16. Smith LM, Peroutka SJ: Differential effects of 5-hydroxytryptamine 1a selective drugs on the 5-HT behavioral syndrome. Pharmacol Biochem Behav 1986; 24:1513-1519
17. Preskorn SH, Berber JH, Faul JC, et al: Serious adverse effects of combining fluoxetine with tricyclic antidepressants. Am J Psychiatry 1990; 147:532
18. Bergstrom RF, Peyton AL, Lemberger L: Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction. Clin Pharmacol Ther 1992; 51:239-248
19. Muller N, Brockmoller J, Roots I: Extremely long plasma half-life of amitriptyline in a woman with the cytochrome P450IID6 29/29-kilobase wildtype allele - A slowly reversible interaction with fluoxetine. Ther Drug Monit 1991; 13:533-536
20. Aranow AB, Hudson JI, Pope HG Jr, et al: Elevated antidepressant plasma levels after the addition of fluoxetine. Am J Psychiatry 1989; 146:911-913
21. Lappin RI, Auchincloss EL: Treatment of the serotonin syndrome with cyproheptadine. N Engl J Med 1994; 331: 1021-1022
22. Kuisma MJ: Fatal serotonin syndrome with trismus. Ann Emerg Med 1995; 26: 108
23. Ruiz F: Fluoxetine and the serotonin syndrome. Ann Emerg Med 1994; 24: 983-985
24. Guze BH, Baxter LR Jr: The serotonin syndrome: Case responsive to propranolol. J Clin Psychopharmacol 1986; 6:119-120
25. Sandyk R: L-Dopa induced "serotonin syndrome" in a parkinsonian patient on bromocriptine. J Clin Psychopharmacol 1986; 6:194-195
26. Barone JA, Jessen LM, Colaizzi JL, et al: Cisapride: A gastrointestinal prokinetic drug. Ann Pharmacother 1994; 28:488-500
27. Skop BP, Finkelstein JA, Mareth TR, et al: The serotonin syndrome associated with paraoxetine, an over-the-counter cold remedy, and vascular disease. Am J Emerg Med 1994; 12:642-644
28. Achamallah NS: Visual hallucinations after combining fluoxetine and dextromethorphan. Am J Psychiatry 1992; 149:1406